Summary
2-MeO-DMT (2-methoxy-N,N-dimethyltryptamine) is a rare research chemical first described in the 1960s. Human data are sparse; doses and timelines above are extrapolated from a handful of forum reports (DMT-Nexus, Reddit) and its lower affinity for 5-HT2A relative to DMT in vitro. Users consistently describe markedly milder visuals than DMT but pronounced bodily warmth, slight dissociation, and a dreamy head-space. Many compare it to a cross between low-dose DMT and 5-MeO-DMT, though without the ego-dissolving intensity. Because safety data are limited, start with allergy test (<3 mg vaporized) and titrate slowly.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Vaporized | 0-1 min | 5-15 min | 10-20 min | 0.5-2 hrs |
| Insufflated | 5-15 min | 20-45 min | 40-60 min | 0.5-2 hrs |
| Oral | 30-60 min | 1-2 hrs | 1-2 hrs | 0.5-2 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Effects
Positive
- Anxiolysis
- Stimulation
- Physical euphoria
Negative
- Physical heaviness or lethargy
- Nausea at higher doses
- Nausea
- Increased heart rate
- Warm body glow
- Head pressure or sinus discomfort
- Sedation
Positive
- Mild euphoria
- Introspection
- Euphoria
Negative
- Anxiety
- Confusion
- Memory suppression
- Dream-like mental state
- Time dilation
- Slight dissociation
- Time distortion
Positive
- Audio enhancement
- Color enhancement
- Tracers
- Tactile enhancement
- Increased music appreciation
- Enhanced tactile sensation
Negative
- Mild closed-eye visuals
- Visual distortions
- Drifting
- Auditory distortion