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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MeO-DMT

    Psychedelic Research-chemical

    Summary TheDrug.Wiki

    2-MeO-DMT (2-methoxy-N,N-dimethyltryptamine) is a rare research chemical first described in the 1960s. Human data are sparse; doses and timelines above are extrapolated from a handful of forum reports (DMT-Nexus, Reddit) and its lower affinity for 5-HT2A relative to DMT in vitro. Users consistently describe markedly milder visuals than DMT but pronounced bodily warmth, slight dissociation, and a dreamy head-space.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Insufflated 5-15 min 20-45 min 40-60 min 0.5-2 hrs
    Oral 30-60 min 1-2 hrs 1-2 hrs 0.5-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.4
    Moderate+ 5/10

    Moderate visuals with mild headspace, auditory effects, and body load

    Visual Intensity ×3
    7
    color enhancement drifting tracers visual distortions
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-MeO-DMT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TheDrug.Wiki

    Positive
    • Anxiolysis
    • Stimulation
    • Physical euphoria
    Negative
    • Physical heaviness or lethargy
    • Nausea at higher doses
    • Nausea
    • Increased heart rate
    Neutral
    • Warm body glow
    • Head pressure or sinus discomfort
    • Sedation
    Positive
    • Mild euphoria
    • Introspection
    • Euphoria
    Negative
    • Anxiety
    • Confusion
    • Memory suppression
    Neutral
    • Dream-like mental state
    • Time dilation
    • Slight dissociation
    • Time distortion
    Positive
    • Audio enhancement
    • Color enhancement
    • Tracers
    • Tactile enhancement
    • Increased music appreciation
    • Enhanced tactile sensation
    Neutral
    • Mild closed-eye visuals
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations TripSit

    2-MeO-DMT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki