2-MeO-DMT
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
2-MeO-DMT (2-methoxy-N,N-dimethyltryptamine) is a rare research chemical first described in the 1960s. Human data are sparse; doses and timelines above are extrapolated from a handful of forum reports (DMT-Nexus, Reddit) and its lower affinity for 5-HT2A relative to DMT in vitro. Users consistently describe markedly milder visuals than DMT but pronounced bodily warmth, slight dissociation, and a dreamy head-space.
Dose Information
| ROA | Threshold |
|---|---|
| Vaporized | 5-10mg |
| Insufflated | 10mg |
| Oral | 30mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Vaporized | 0-36 sec | 5-15 min | 10-20 min | 15-35 min |
| Insufflated | 5-15 min | 20-45 min | 40-60 min | 1.08-2 hrs |
| Oral | 30-60 min | 1-2 hrs | 1-2 hrs | 2.5-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals with mild headspace, auditory effects, and body load
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 2-MeO-DMT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
2-MeO-DMT Source: SubstanceSearch (substancesearch.com) Vaporized dose (mg): threshold 5-10 Insufflated dose (mg): threshold 10 Oral dose (mg): threshold 30 Vaporized duration: onset 0-36s · peak 5-15m · offset 10-20m · total 15-35m · after-effects 0.5-2h Insufflated duration: onset 5-15m · peak 20-45m · offset 0.67-1h · total 1.08-2h · after-effects 0.5-2h Oral duration: onset 0.5-1h · peak 1-2h · offset 1-2h · total 2.5-5h · after-effects 0.5-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Anxiolysis
- Stimulation
- Physical euphoria
- Physical heaviness or lethargy
- Nausea at higher doses
- Nausea
- Increased heart rate
- Warm body glow
- Head pressure or sinus discomfort
- Sedation
- Mild euphoria
- Introspection
- Euphoria
- Anxiety
- Confusion
- Memory suppression
- Dream-like mental state
- Time dilation
- Slight dissociation
- Time distortion
- Audio enhancement
- Color enhancement
- Tracers
- Tactile enhancement
- Increased music appreciation
- Enhanced tactile sensation
- Mild closed-eye visuals
- Visual distortions
- Drifting
- Auditory distortion
Combinations
Cross-Check 2-MeO-DMT with another substanceHelpful Links
Report an issue or suggest an edit
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