2-MeO-DMT
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
2-MeO-DMT (2-methoxy-N,N-dimethyltryptamine) is a rare research chemical first described in the 1960s. Human data are sparse; doses and timelines above are extrapolated from a handful of forum reports (DMT-Nexus, Reddit) and its lower affinity for 5-HT2A relative to DMT in vitro. Users consistently describe markedly milder visuals than DMT but pronounced bodily warmth, slight dissociation, and a dreamy head-space.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Vaporized | 0-1 min | 5-15 min | 10-20 min |
| Insufflated | 5-15 min | 20-45 min | 40-60 min |
| Oral | 30-60 min | 1-2 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals with mild headspace, auditory effects, and body load
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Anxiolysis
- Stimulation
- Physical euphoria
- Physical heaviness or lethargy
- Nausea at higher doses
- Nausea
- Increased heart rate
- Warm body glow
- Head pressure or sinus discomfort
- Sedation
- Mild euphoria
- Introspection
- Euphoria
- Anxiety
- Confusion
- Memory suppression
- Dream-like mental state
- Time dilation
- Slight dissociation
- Time distortion
- Audio enhancement
- Color enhancement
- Tracers
- Tactile enhancement
- Increased music appreciation
- Enhanced tactile sensation
- Mild closed-eye visuals
- Visual distortions
- Drifting
- Auditory distortion
Combinations
Cross-Check 2-MeO-DMT with another substanceHelpful Links
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