Summary
2-MPPP (2-methyl-1-phenyl-3-(piperidin-1-yl)propan-1-one) is a little-studied research chemical first reported in 2014-2015. No formal toxicology or pharmacokinetic data exist. Users describe short-lived, 'clean' mental stimulation with mild euphoria, minimal peripheral push, and a relatively soft comedown. Neurotoxicity, cardiotoxicity, and long-term health effects are unknown; treat with the same caution as any novel cathinone-like stimulant. Use accurate scales (ยฑ1 mg), start low, stay hydrated, avoid redosing more than once per 4-6 hours, and monitor blood pressure and heart rate.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-100mg | 100-150mg | 150mg++ |
| Insufflated | 15-30mg | 30-60mg | 60-110mg | 110mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 20-30 min | 30-90 min | 1-2 hrs | 1-12 hrs | 120-0 min |
| Insufflated | 3-7 min | 30-90 min | 1-2 hrs | 1-12 hrs | 120-0 min |
| Rectal | 2-5 min | 30-90 min | 1-2 hrs | 1-12 hrs | 120-0 min |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Mental stimulation/alertness
- Increased energy/alertness
Negative
- Bruxism and jaw tension
- Mild vasoconstriction
- Sweating
- Tachycardia and elevated blood pressure
- Insomnia
- Weight loss
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
Positive
- Euphoria
- Mood elevation
- Increased sociability and talkativeness
- Motivation enhancement
- Increased sociability
- Mood lift
Negative
- Anxiety or irritability on comedown
- Aggressiveness
- Excessive talking
- Moodiness
Positive
- Music appreciation enhancement
- Color enhancement
- Increased music appreciation
- Brightened colour
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Increased sexuality
- Visual and auditory hallucinations
- Dulled perception