2-PA Stats & Data
NC(=O)Cc1ccccc1LSBDFXRDZJMBSC-UHFFFAOYSA-NReceptor Profile
Receptor Actions
Effect Profile
CuratedStrong anxiety/jitters with moderate euphoria, mild focus, low stimulation
Tolerance & Pharmacokinetics
drugs.wikiCross-Tolerances
Harm Reduction
drugs.wikiIdentity warning: Reports indicate some vendors use the name “2-PA” for the parent cathinone (2‑amino‑1‑phenyl‑1‑propanone), while others confuse it with 2‑phenylacetamide (a different, non-stimulant amide); verify with reagent or laboratory testing before dosing. Cathinone itself is scheduled in multiple jurisdictions (e.g., US Schedule I), so materials that actually are the parent cathinone carry significant legal risk. Assume typical cathinone stimulant risks: tachycardia, hypertension, vasoconstriction, hyperthermia, anxiety, insomnia, and a strong urge to redose—avoid consecutive-day or continuous use. For oral use, wait at least 2 hours before considering any redose to avoid stacking. Hydrate with electrolytes (not only water) and take cooling breaks in hot or crowded settings to reduce hyperthermia risk; do not overhydrate due to hyponatremia risk. Insufflation commonly causes marked nasal irritation; mitigate by using fine powders, alternating nostrils, and rinsing with sterile saline after sessions; avoid oxymetazoline longer than 3 days due to rebound congestion. Avoid combining with MAOIs (including harmala alkaloids) due to hypertensive crisis risk, and avoid combining with bupropion or tramadol because of additive seizure risk. Stimulant markets frequently show mislabeling/adulteration (e.g., samples sold as one cathinone containing different cathinones or, in stimulant markets, unexpected benzodiazepines/nitazenes), so drug checking is strongly recommended before use. People with cardiovascular disease, hypertension, glaucoma, hyperthyroidism, or a history of seizures should avoid use; seek medical evaluation if chest pain, severe headache, hyperthermia, confusion, or persistent agitation occur.
References
Cited References
- Baumann MH et al. Bath salts, spice, and related designer drugs. Neuropsychopharmacology. 2014
- German CL et al. Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci. 2014
- Glennon RA et al. Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones. Front Psychiatry. 2023
- Katselou M et al. The pharmacology of substituted cathinones. Front Neurosci. 2016
- Prosser JM, Nelson LS. The toxicology of bath salts (synthetic cathinones). Emerg Med Clin North Am. 2013
- TripSit Factsheet: 2-PA
- Valente MJ et al. Khat and synthetic cathinones: a review. Arch Toxicol. 2014
Drugs.wiki References
- Cathinone identified as 2-amino-1-phenyl-1-propanone (parent structure)
- Khat basics; cathinone pharmacology and half-life around 4 h; peak ~2 h when chewed
- ECDD critical review; human cathinone terminal t1/2 1.5 ± 0.8 h; dose data in chewers
- Cathinone legal status (example: US Schedule I)
- MAOI interaction summary: avoid combining MAOIs with stimulants (incl. MDMA)
- Bupropion lowers seizure threshold; structural relation to cathinone
- Erowid Bupropion basics; seizure incidence is dose-dependent
- MDMA hydration guidance: avoid both dehydration and overhydration (hyponatremia)
- Nasal care HR for insufflation (saline rinses; healing)
- Cathinone/cathinone-like stimulants often mislabeled; repeated Swiss alerts (examples)
- Additional mislabeling alerts within cathinone market (examples)
- Drug checking bulletins showing high adulteration rates in stimulant markets