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    2-PA molecular structure

    2-PA Stats & Data

    2-phenylacetamide
    NPS DataHub
    MW135.17
    FormulaC8H9NO
    CAS103-81-1
    IUPAC2-phenylacetamide
    SMILESNC(=O)Cc1ccccc1
    InChIKeyLSBDFXRDZJMBSC-UHFFFAOYSA-N
    Chemical Class Cathinone
    Psychoactive Class Stimulant
    Half-Life ~1.5–4.3 h (parent cathinone estimates in humans; route- and dose-dependent)

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine reuptake inhibitor
    Norepinephrine reuptake inhibitor (presumed cathinone-like activity)
    Other
    Dopamine releasing agent
    Norepinephrine releasing agent

    Effect Profile

    Curated
    Stimulant 4.1

    Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    5
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    ~1.5–4.3 h (parent cathinone estimates in humans; route- and dose-dependent)
    Addiction Potential
    Moderate to high. Like other cathinone-type stimulants, repeated use rapidly produces psychological craving, tolerance, and a binge-style pattern of redosing.

    Cross-Tolerances

    other cathinones
    50% ●○○
    amphetamines
    40% ●○○

    Harm Reduction

    drugs.wiki

    Identity warning: Reports indicate some vendors use the name “2-PA” for the parent cathinone (2‑amino‑1‑phenyl‑1‑propanone), while others confuse it with 2‑phenylacetamide (a different, non-stimulant amide); verify with reagent or laboratory testing before dosing. Cathinone itself is scheduled in multiple jurisdictions (e.g., US Schedule I), so materials that actually are the parent cathinone carry significant legal risk. Assume typical cathinone stimulant risks: tachycardia, hypertension, vasoconstriction, hyperthermia, anxiety, insomnia, and a strong urge to redose—avoid consecutive-day or continuous use. For oral use, wait at least 2 hours before considering any redose to avoid stacking. Hydrate with electrolytes (not only water) and take cooling breaks in hot or crowded settings to reduce hyperthermia risk; do not overhydrate due to hyponatremia risk. Insufflation commonly causes marked nasal irritation; mitigate by using fine powders, alternating nostrils, and rinsing with sterile saline after sessions; avoid oxymetazoline longer than 3 days due to rebound congestion. Avoid combining with MAOIs (including harmala alkaloids) due to hypertensive crisis risk, and avoid combining with bupropion or tramadol because of additive seizure risk. Stimulant markets frequently show mislabeling/adulteration (e.g., samples sold as one cathinone containing different cathinones or, in stimulant markets, unexpected benzodiazepines/nitazenes), so drug checking is strongly recommended before use. People with cardiovascular disease, hypertension, glaucoma, hyperthyroidism, or a history of seizures should avoid use; seek medical evaluation if chest pain, severe headache, hyperthermia, confusion, or persistent agitation occur.

    References

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