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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-PA

    Aliases: 2-phenylacetamide

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    2-PA is an extremely obscure beta-keto phenethylamine with almost no documented human use. TripSit describes it as amphetamine with the alpha-methyl replaced by a ketone. Human data are limited to a handful of online self-experiments; no formal pharmacology, toxicology, or safety studies exist.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-50mg 50-100mg 100+mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-45 min 30-60 min 1-2 hrs 1-2 hrs 1-10 hrs 2.8-5.8 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 1-2 hrs 1-10 hrs 2.3-4.8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.1
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness teeth grinding increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-PA
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Cross-Tolerances

    other cathinones
    50%
    amphetamines
    40%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Insomnia
    • Increased heart rate
    • Pupil dilation
    • Nausea
    • Restlessness
    Neutral
    • Sedation
    • Decreased appetite
    Positive
    • Euphoria
    • Focus enhancement
    • Motivation enhancement
    • Sociability enhancement
    • Cognitive euphoria
    Negative
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    • Talkativeness
    Positive
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Closed/Open eye visuals
    • Drifting

    Combinations TripSit

    2-PA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki