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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-PA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: 2-phenylacetamide

    Stimulant Research-chemical

    Summary dose.wiki TripSit

    2-PA is an extremely obscure beta-keto phenethylamine with almost no documented human use. TripSit describes it as amphetamine with the alpha-methyl replaced by a ketone. Human data are limited to a handful of online self-experiments; no formal pharmacology, toxicology, or safety studies exist.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-50mg 50-100mg 100+mg
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-45 min 30-60 min 1-2 hrs 1-2 hrs 1-10 hrs 3-5 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 1-2 hrs 1-10 hrs 3-5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.1
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild focus, low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness teeth grinding increased heart rate vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-PA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-PA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-PA
    Unit
    mg
    Description 
    2-PA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 10-25 · common 25-50 · strong 50-100 · heavy 100+
Insufflated dose (mg): threshold 5

Oral duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 1-2h · total 3-5h · after-effects 1-10h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 1-2h · total 3-5h · after-effects 1-10h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Half tolerance 2d Baseline ~5d

    Anecdotal stimulant tolerance pattern: rapid within-session tachyphylaxis and persistent downregulation for days after binges; allow multi-week breaks to reduce compulsive redosing risk.

    Cross-Tolerances

    other cathinones
    50%
    amphetamines
    40%

    Effects dose.wiki

    Positive
    • Stimulation
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Insomnia
    • Increased heart rate
    • Pupil dilation
    • Nausea
    • Restlessness
    Neutral
    • Sedation
    • Decreased appetite
    Positive
    • Euphoria
    • Focus enhancement
    • Motivation enhancement
    • Sociability enhancement
    • Cognitive euphoria
    Negative
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    • Talkativeness
    Positive
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Closed/Open eye visuals
    • Drifting

    Combinations TripSit

    Cross-Check 2-PA with another substance

    2-PA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 TripSit 📖 PsychonautWiki