2,5-DMA
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Dma, Doh, 2,5-dimethoxyamphetamine
Summary
2,5-DMA is a research chemical and the simplest member of the DOx family, primarily known as a precursor in synthesizing other psychedelic amphetamines rather than for its own psychoactive effects. Unlike typical psychedelics, it produces primarily stimulant and physical effects with minimal to no sensory or perceptual changes. Very little data exists about its pharmacology, metabolism, and toxicity.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-40mg | 40-80mg | 80-200mg | 200mg+ |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals and body load with mild auditory effects, low headspace
Strong anxiety/jitters with moderate stimulation and euphoria, low focus
Import into PsychonautWiki Journal
The PsychonautWiki Journal app includes 2,5-DMA, but its built-in data can be thinner than ours. Importing this file adds a separate "2,5-DMA (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.
Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Physical Stimulation
- Stimulation
- Increased Heart Rate
- Increased Blood Pressure
- Pupil Dilation
- Muscle Tension
- Tremors
- Temperature Regulation Suppression
- Increased Perspiration
- Spontaneous bodily sensations
- Enhanced Interest In Surroundings
- Motivation enhancement
- Novelty enhancement
- Cognitive euphoria
- Wakefulness
- Increased sense of humor
- Euphoria
- Paranoia
- Anxiety
- Time distortion
- Color enhancement
- Increased music appreciation
- Tracers
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
- Light sensitivity
- Spontaneous Physical Sensations
- Drifting
- Auditory distortion
Combinations
Cross-Check 2,5-DMA with another substancePiHKAL / TiHKAL
Helpful Links
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