2,5-DMA
Aliases: Dma, Doh, 2,5-dimethoxyamphetamine
Summary
2,5-DMA is a research chemical and the simplest member of the DOx family, primarily known as a precursor in synthesizing other psychedelic amphetamines rather than for its own psychoactive effects. Unlike typical psychedelics, it produces primarily stimulant and physical effects with minimal to no sensory or perceptual changes. Very little data exists about its pharmacology, metabolism, and toxicity.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-40mg | 40-80mg | 80-200mg | 200mg+ |
Light
Common
Strong
Heavy
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
4.0
Moderate
4/10
Moderate visuals and body load with mild auditory effects, low headspace
Visual Intensity
×3
7
color enhancement
drifting
tracers
pattern recognition enhancement
Headspace Depth
×3
1
time distortion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
6
temperature regulation suppression
muscle tension
increased heart rate
Stimulant
4.9
Moderate+
5/10
Strong anxiety/jitters with moderate stimulation and euphoria, low focus
Stimulation / Energy
×3
7
physical stimulation
stimulation
wakefulness
Euphoria / Mood Lift
×2
7
cognitive euphoria
euphoria
motivation enhancement
Focus / Productivity
×2
2
motivation enhancement
Anxiety / Jitters
×1
10
anxiety
paranoia
increased heart rate
muscle tension
tremors
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Effects
Positive
- Physical Stimulation
- Stimulation
Negative
- Increased Heart Rate
- Increased Blood Pressure
- Pupil Dilation
- Muscle Tension
- Tremors
- Temperature Regulation Suppression
- Increased Perspiration
- Spontaneous bodily sensations
Positive
- Enhanced Interest In Surroundings
- Motivation enhancement
- Novelty enhancement
- Cognitive euphoria
- Wakefulness
- Increased sense of humor
- Euphoria
Negative
- Paranoia
- Anxiety
- Time distortion
Positive
- Color enhancement
- Increased music appreciation
- Tracers
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
Negative
- Light sensitivity
- Spontaneous Physical Sensations
- Drifting
- Auditory distortion
Combinations
PiHKAL / TiHKAL
2,5-DMA's nerd page
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