2,5-DMA
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: Dma, Doh, 2,5-dimethoxyamphetamine
Summary
2,5-DMA is a research chemical and the simplest member of the DOx family, primarily known as a precursor in synthesizing other psychedelic amphetamines rather than for its own psychoactive effects. Unlike typical psychedelics, it produces primarily stimulant and physical effects with minimal to no sensory or perceptual changes. Very little data exists about its pharmacology, metabolism, and toxicity.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-40mg | 40-80mg | 80-200mg | 200mg+ |
Onset, Duration & After-effects
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals and body load with mild auditory effects, low headspace
Strong anxiety/jitters with moderate stimulation and euphoria, low focus
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Physical Stimulation
- Stimulation
- Increased Heart Rate
- Increased Blood Pressure
- Pupil Dilation
- Muscle Tension
- Tremors
- Temperature Regulation Suppression
- Increased Perspiration
- Spontaneous bodily sensations
- Enhanced Interest In Surroundings
- Motivation enhancement
- Novelty enhancement
- Cognitive euphoria
- Wakefulness
- Increased sense of humor
- Euphoria
- Paranoia
- Anxiety
- Time distortion
- Color enhancement
- Increased music appreciation
- Tracers
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
- Light sensitivity
- Spontaneous Physical Sensations
- Drifting
- Auditory distortion
Combinations
Cross-Check 2,5-DMA with another substancePiHKAL / TiHKAL
Helpful Links
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