25B-NBOH - Substance Search

Summary TheDrug.Wiki TripSit PsychonautWiki

25B-NBOH is a potent synthetic psychedelic that is often misrepresented as LSD in powder or blotter form. Due to its extreme potency and unpredictable dose-response, it poses significant health risks including seizures, vasoconstriction, hyperthermia, and acute kidney injury. Insufflation (snorting) is especially dangerous and has been linked to rapid-onset status epilepticus.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Buccal	200-400ug	400-800ug	800ug-1mg+	-
Sublingual	200-400ug	400-800ug	800ug-1mg	1mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Buccal	20-40 min	30-60 min	2-4 hrs	2-6 hrs	12-12 hrs	4.8-11.7 hrs
Sublingual	20-40 min	-	4-10 hrs	-	1-12 hrs	4.3-10.7 hrs

Effect Profile

6 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 8.4

Intense 8/10

Strong visuals, auditory effects, body load, and headspace

Visual Intensity ×3

10

color enhancement drifting tracers synaesthesia pattern recognition enhancement scenery slicing +6 more

Headspace Depth ×3

9

conceptual thinking recursion emotion enhancement personal bias suppression time distortion confusion

Auditory Effects ×1

10

auditory distortion auditory hallucination synaesthesia

⚠ Body Load / Somatic Effects ×1

10

vasoconstriction temperature regulation suppression nausea muscle tension increased heart rate

Based on reports from:

Erowid Experience Reports PsychonautWiki 25B-NBOH

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 12h Half tolerance 4d Baseline ~7d

Immediate acute tolerance develops after dosing; cross‑tolerance with other 5‑HT2A agonists is expected. Anecdotal reports suggest tolerance may persist ~1–2 weeks depending on dose and individual variability. Data quality is limited and primarily anecdotal.