Let me start this off by saying this is a beautiful chemical. As with any other chemical treat it with respect and it will pay you back with consistent enjoyable effects. I started my research on this compound , 500ug sublingual For me, not much to write home about.
25B-NBOH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Tentative
- classified Research-chemical
Aliases: Nboh-2c-b, 2c-b-nboh, 25bnboh, nboh-2cb, 2cb-nboh
Summary
25B-NBOH is a potent synthetic psychedelic that is often misrepresented as LSD in powder or blotter form. Due to its extreme potency and unpredictable dose-response, it poses significant health risks including seizures, vasoconstriction, hyperthermia, and acute kidney injury. Insufflation (snorting) is especially dangerous and has been linked to rapid-onset status epilepticus.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Buccal | 200-400ug | 400-800ug | 800ug-1mg | 1mg+ |
| Sublingual | 200-400ug | 400-800ug | 800ug-1mg | 1mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Buccal | 20-40 min | 30-60 min | 2-4 hrs | 2-6 hrs | 4-10 hrs |
| Sublingual | 20-40 min | - | 4-10 hrs | - | 4-10 hrs |
Effect Profile
6 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.4
Intense
8/10
Strong visuals, auditory effects, body load, and headspace
Visual Intensity
×3
10
color enhancement
drifting
tracers
synaesthesia
pattern recognition enhancement
scenery slicing
+6 more
Headspace Depth
×3
9
conceptual thinking
recursion
emotion enhancement
personal bias suppression
time distortion
confusion
Auditory Effects
×1
10
auditory distortion
auditory hallucination
synaesthesia
Body Load / Somatic Effects
×1
10
vasoconstriction
temperature regulation suppression
nausea
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7β14 days for baseline
Tolerance Decay
Full tolerance
12h
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Immediate acute tolerance develops after dosing; crossβtolerance with other 5βHT2A agonists is expected. Anecdotal reports suggest tolerance may persist ~1β2 weeks depending on dose and individual variability. Data quality is limited and primarily anecdotal.
Cross-Tolerances
Effects
Aggregated from 6 Erowid experience reports
Positive Effects 6
Color Enhancement
100.0%
70%
Empathy
83.3%
70%
Introspection
66.7%
70%
Stimulation
66.7%
70%
Music Enhancement
50.0%
70%
Euphoria
50.0%
70%
Adverse Effects 1
Anxiety
50.0%
70%
Combinations
Cross-Check 25B-NBOH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 4 reports 1 positive 2 neutral 1 cautionary visit
Some background: IΒve tripped pretty heavily on literally dozens of psychedelics before this point, and am an experienced drug user on many accounts, but this compound still took me by surprise.
+0:00 100 micrograms 25b-nboh IV +0:05 We've reached peak visuals. The best way to describe this is one of those metal lawn ornaments that spins in the wind, usually in a butterfly or dragonfly shape that spins in the wind. Open eye, field of view is distorted into that.
Sensory Overload, a Phenomal Experience! I bought some 25B-NBOH and put it on blotters myself, each containing 500ug. I'm pretty excited about this substance because I expect it to be a bit like 2C-B given its chemical structure. 2C-B is one of my favorite substances.
25B-NBOH's nerd page
Pharmacology, chemical data, effect profiles, and more
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