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    Disclaimer
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25C-NB3OMe Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 4 corroborating sources
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 30c-nbome, 2c-c-nb3ome, Nb3ome-2c-c, 25c-nb345ome

    Psychedelic Research-chemical

    Summary dose.wiki

    C30-NBOMe (also known as 30C-NBOMe or 25C-NB345OMe) is structurally distinct from typical NBOMes due to its 3,4,5-trimethoxybenzyl group (mescaline-like pattern) rather than the standard 2-methoxybenzyl group. Despite being theoretically related to active NBOMe compounds, extensive anecdotal evidence from 2013-2016 indicates this substance produces minimal to no psychoactive effects at doses ranging from micrograms to hundreds of milligrams across multiple routes of administration. Only one isolated positive report exists amid numerous reports of complete inactivity.

    Dose Information Drugs.Wiki

    Dose basis. 25C-NB3OMe belongs to the NBOMe family, whose members are active below 1 mg. There is no reliable human dosing data for it. The thresholds shown are in micrograms (µg) and come from Drugs.Wiki, which builds them from scattered community reports for the class and calls them uncertain. NBOMes work poorly and unpredictably when swallowed, so no oral dose is given.

    ROA Threshold
    Buccal 200-400µg
    Insufflated 100-300µg

    Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.

    Sources

    Buccal

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Buccal 20-60 min 30-60 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 4.33-9.5 hrs
    Insufflated 5-20 min 15-30 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 3.83-8.33 hrs
    Oral 30-90 min 45-90 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs 4.75-10.5 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.0
    Strong 6/10

    Strong visuals and auditory effects with strong body load, mild headspace

    Visual Intensity ×3
    9
    visual geometry color enhancement drifting tracers visual distortions
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    8
    auditory enhancement auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    9
    body load nausea teeth grinding increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Patterns extrapolated from classical psychedelic tolerance; individual variability is high. Repeated high‑frequency use may cause prolonged after‑effects or HPPD‑like symptoms as reported anecdotally.

    Cross-Tolerances

    LSD
    2C-series phenethylamines
    other NBOMe/NBOH psychedelics

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • No consistent psychoactive effects reported
    Positive
    Neutral

    Combinations TripSit

    Cross-Check 25C-NB3OMe with another substance

    25C-NB3OMe is an NBOMe-family compound (the 3-methoxy isomer of 25C-NBOMe), so these are TripSit's NBOMe interactions. It used to carry the milder set TripSit gives 2C-x drugs.

    25C-NB3OMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25C-NB3OMe there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    25C-NB3OMe
    Unit
    µg
    Description 
    25C-NB3OMe
Source: SubstanceSearch (substancesearch.com)

Buccal dose (µg): threshold 200-400
Insufflated dose (µg): threshold 100-300

Buccal duration: onset 0.33-1h · come-up 0.5-1h · peak 1.5-3.5h · offset 2-4h · total 4.33-9.5h · after-effects 2-6h
Insufflated duration: onset 5-20m · come-up 15-30m · peak 1.5-3.5h · offset 2-4h · total 3.83-8.33h · after-effects 2-6h
Oral duration: onset 0.5-1.5h · come-up 0.75-1.5h · peak 1.5-3.5h · offset 2-4h · total 4.75-10.5h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.