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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25C-NB3OMe

    Aliases: 30c-nbome, 2c-c-nb3ome, Nb3ome-2c-c, 25c-nb345ome

    Psychedelic Research-chemical

    Summary TheDrug.Wiki

    C30-NBOMe (also known as 30C-NBOMe or 25C-NB345OMe) is structurally distinct from typical NBOMes due to its 3,4,5-trimethoxybenzyl group (mescaline-like pattern) rather than the standard 2-methoxybenzyl group. Despite being theoretically related to active NBOMe compounds, extensive anecdotal evidence from 2013-2016 indicates this substance produces minimal to no psychoactive effects at doses ranging from micrograms to hundreds of milligrams across multiple routes of administration. Only one isolated positive report exists amid numerous reports of complete inactivity.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral —mg - - Noreliableeffectsat300+mg+
    Sublingual —mg - - Noeffectsobservedat50+mg+
    Intravenous - - - Noeffectsreportedat20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Buccal 20-60 min 30-60 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs
    Insufflated 5-20 min 15-30 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs
    Oral 30-90 min 45-90 min 1.5-3.5 hrs 2-4 hrs 2-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.0
    Strong 6/10

    Strong visuals, body load, and auditory effects with mild headspace

    Visual Intensity ×3
    9
    visual geometry color enhancement drifting tracers visual distortions
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    8
    auditory enhancement auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    9
    body load nausea teeth grinding increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25C-NB3OMe
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Patterns extrapolated from classical psychedelic tolerance; individual variability is high. Repeated high‑frequency use may cause prolonged after‑effects or HPPD‑like symptoms as reported anecdotally.

    Cross-Tolerances

    LSD
    60%
    2C-series phenethylamines
    50%
    other NBOMe/NBOH psychedelics
    80%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Peripheral vasoconstriction
    • Body load
    • Teeth grinding
    • Nausea
    • Increased heart rate
    • Pupil dilation
    Neutral
    • Dilated pupils
    • Sedation
    Positive
    • Euphoria
    • Empathy
    • After-glow
    • Conceptual thinking
    Negative
    • Anxiety
    • Confusion
    • Memory suppression
    • Motor control loss
    Neutral
    • Time distortion
    • No consistent psychoactive effects reported
    Positive
    • Visual geometry
    • Color enhancement
    • Auditory enhancement
    • Tactile enhancement
    • Tracers
    • Increased music appreciation
    • Enhanced tactile sensation
    Neutral
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations TripSit

    25C-NB3OMe's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki