Summary
25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness. Visuals are intense and geometric, with cognitive effects more acute than LSD at equivalent intensity. Exercise extreme caution with dosing due to high potency and vasoconstriction effects.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Buccal | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs | 12 hrs |
| Sublingual | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs | 12 hrs |
| Intranasal | 2-5 min | 15-30 min | 1-3 hrs | 3-5 hrs | 12 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Vasoconstriction
- Tachycardia
- Temperature Regulation Suppression
- Nausea
- Increased heart rate
- Pupil dilation
- Dilated pupils
- Sedation
Positive
- Euphoria
- Conceptual thinking
Negative
- Emotional Suppression
- Thought Deceleration
- Anxiety
- Confusion
- Memory suppression
- Time Distortion
- Cognitive Disorganization
- Time distortion
Positive
- Tracers
- Color enhancement
- Tactile enhancement
- Increased music appreciation
Negative
- Tactile Suppression
- Geometric Visual Patterning
- Complex Visual Imagery
- Visual distortions
- Drifting
- Auditory distortion