25CN-NBOH
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Nboh-2c-cn
Summary
25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness.
Dose Information
Dose basis. Ranges are stitched from scattered user reports of NBOH/NBOMe analogues; no clinical dosing exists. Microgram potency means uneven blotter or mismeasured liquid can cause overdose—use volumetric dosing and avoid eyeballing. Powder dosing is discouraged due to potency and past poisonings from misrepresentation on the market. Hold for 15–20 minutes to maximize transmucosal absorption; swallowing early lowers and delays effects but does not reliably ‘deactivate’ NBOH/NBOMe. Bitter/metallic taste and local numbness are common; spit after holding if GI upset occurs. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Buccal | 100-300µg | 300-800µg | 800-1200µg | 1200µg+ |
| Sublingual | 100-300µg | 300-800µg | 800-1200µg | 1200µg+ |
| Insufflated | 50-150µg | 150-400µg | 400-700µg | 700µg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Buccal | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs | 4.67-9.5 hrs |
| Sublingual | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs | 4.67-9.5 hrs |
| Insufflated | 2-5 min | 15-30 min | 1-3 hrs | 3-5 hrs | 4.28-8.58 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong body load with moderate visuals, mild headspace and auditory effects
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 25CN-NBOH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
25CN-NBOH Source: SubstanceSearch (substancesearch.com) Buccal dose (µg): threshold 50-100 · light 100-300 · common 300-800 · strong 800-1200 · heavy 1200+ Sublingual dose (µg): threshold 50-100 · light 100-300 · common 300-800 · strong 800-1200 · heavy 1200+ Insufflated dose (µg): threshold 20-50 · light 50-150 · common 150-400 · strong 400-700 · heavy 700+ Buccal duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 3-5h · total 4.67-9.5h · after-effects 12h Sublingual duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 3-5h · total 4.67-9.5h · after-effects 12h Insufflated duration: onset 2-5m · come-up 15-30m · peak 1-3h · offset 3-5h · total 4.28-8.58h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 550 µg (Buccal).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Practical guidance from community reports: tolerance is substantial after one session, halves over ~3–5 days and returns near baseline by 7–14 days; two weeks between strong experiences is a cautious rule of thumb. Cross‑tolerance exists across classical psychedelics. Evidence quality is anecdotal.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Vasoconstriction
- Tachycardia
- Temperature Regulation Suppression
- Nausea
- Increased heart rate
- Pupil dilation
- Dilated pupils
- Sedation
- Euphoria
- Conceptual thinking
- Emotional Suppression
- Thought Deceleration
- Anxiety
- Confusion
- Memory suppression
- Time Distortion
- Cognitive Disorganization
- Tracers
- Color enhancement
- Tactile enhancement
- Increased music appreciation
- Tactile Suppression
- Geometric Visual Patterning
- Complex Visual Imagery
- Visual distortions
- Drifting
- Auditory distortion
Combinations
Cross-Check 25CN-NBOH with another substanceHelpful Links
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