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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25CN-NBOH Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Nboh-2c-cn

    Psychedelic Research-chemical

    Summary TheDrug.Wiki

    25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Buccal 100-300µg 300-800µg 800-1200µg 1200µg+
    Sublingual 100-300µg 300-800µg 800-1200µg 1200µg+
    Insufflated 50-150µg 150-400µg 400-700µg 700µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Peak Offset After Effects Total
    Buccal 1-3 hrs 3-5 hrs 12 hrs 6-10 hrs
    Sublingual 1-3 hrs 3-5 hrs 12 hrs 6-10 hrs
    Insufflated 1-3 hrs 3-5 hrs 12 hrs 6-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.0
    Moderate+ 5/10

    Strong body load with moderate visuals, mild headspace and auditory effects

    Visual Intensity ×3
    7
    color enhancement tracers drifting visual distortions
    Headspace Depth ×3
    5
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction temperature regulation suppression nausea tachycardia increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25CN-NBOH
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Practical guidance from community reports: tolerance is substantial after one session, halves over ~3–5 days and returns near baseline by 7–14 days; two weeks between strong experiences is a cautious rule of thumb. Cross‑tolerance exists across classical psychedelics. Evidence quality is anecdotal.

    Cross-Tolerances

    psychedelic phenethylamines
    60%
    tryptamines
    50%
    lysergamides
    60%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Vasoconstriction
    • Tachycardia
    • Temperature Regulation Suppression
    • Nausea
    • Increased heart rate
    • Pupil dilation
    Neutral
    • Dilated pupils
    • Sedation
    Positive
    • Euphoria
    • Conceptual thinking
    Negative
    • Emotional Suppression
    • Thought Deceleration
    • Anxiety
    • Confusion
    • Memory suppression
    Neutral
    • Time Distortion
    • Cognitive Disorganization
    • Time distortion
    Positive
    • Tracers
    • Color enhancement
    • Tactile enhancement
    • Increased music appreciation
    Negative
    • Tactile Suppression
    Neutral
    • Geometric Visual Patterning
    • Complex Visual Imagery
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations TripSit

    Cross-Check 25CN-NBOH with another substance

    25CN-NBOH's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki