25CN-NBOH
Aliases: Nboh-2c-cn
Summary
25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Buccal | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs |
| Sublingual | 10-30 min | 30-60 min | 1-3 hrs | 3-5 hrs |
| Intranasal | 2-5 min | 15-30 min | 1-3 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
5.0
Moderate+
5/10
Strong body load with moderate visuals, mild headspace and auditory effects
Visual Intensity
×3
7
color enhancement
tracers
drifting
visual distortions
Headspace Depth
×3
5
conceptual thinking
time distortion
confusion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
10
vasoconstriction
temperature regulation suppression
nausea
tachycardia
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Cross-Tolerances
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Vasoconstriction
- Tachycardia
- Temperature Regulation Suppression
- Nausea
- Increased heart rate
- Pupil dilation
- Dilated pupils
- Sedation
Positive
- Euphoria
- Conceptual thinking
Negative
- Emotional Suppression
- Thought Deceleration
- Anxiety
- Confusion
- Memory suppression
- Time Distortion
- Cognitive Disorganization
- Time distortion
Positive
- Tracers
- Color enhancement
- Tactile enhancement
- Increased music appreciation
Negative
- Tactile Suppression
- Geometric Visual Patterning
- Complex Visual Imagery
- Visual distortions
- Drifting
- Auditory distortion
Combinations
25CN-NBOH's nerd page
Pharmacology, chemical data, effect profiles, and more
→