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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25CN-NBOH Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 29 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Nboh-2c-cn

    Psychedelic Research-chemical

    Summary dose.wiki

    25CN-NBOH is one of the most 5-HT2A-selective agonists discovered; cyano substitution markedly reduces off-target 5-HT2B and 5-HT2C activity compared to other NBOMe/NBOH compounds. Buccal or sublingual absorption is strongly preferred over oral. Users consistently report pronounced vasoconstriction and mouth numbness.

    Dose Information Drugs.Wiki

    Dose basis. Buccal: Ranges are stitched from scattered user reports of NBOH/NBOMe analogues; no clinical dosing exists. Microgram potency means uneven blotter or mismeasured liquid can cause overdose—use volumetric dosing and avoid eyeballing. Powder dosing is discouraged due to potency and past poisonings from misrepresentation on the market. Sublingual: Hold for 15–20 minutes to maximize transmucosal absorption; swallowing early lowers and delays effects but does not reliably ‘deactivate’ NBOH/NBOMe. Bitter/metallic taste and local numbness are common; spit after holding if GI upset occurs. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Buccal 100-300µg 300-800µg 800-1200µg 1200µg+
    Sublingual 100-300µg 300-800µg 800-1200µg 1200µg+
    Insufflated 50-150µg 150-400µg 400-700µg 700µg+
    Light Common Strong Heavy
    Sources

    Buccal

    Dose ladder — Drugs.Wiki

    Sublingual

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Buccal 10-30 min 30-60 min 1-3 hrs 3-5 hrs 12 hrs 4.67-9.5 hrs
    Sublingual 10-30 min 30-60 min 1-3 hrs 3-5 hrs 12 hrs 4.67-9.5 hrs
    Insufflated 2-5 min 15-30 min 1-3 hrs 3-5 hrs 12 hrs 4.28-8.58 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.6
    Moderate+ 5/10

    Moderate visuals with strong body load, mild headspace and auditory effects

    Visual Intensity ×3
    7
    color enhancement tracers drifting visual distortions
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    10
    vasoconstriction temperature regulation suppression nausea tachycardia increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Practical guidance from community reports: tolerance is substantial after one session, halves over ~3–5 days and returns near baseline by 7–14 days; two weeks between strong experiences is a cautious rule of thumb. Cross‑tolerance exists across classical psychedelics. Evidence quality is anecdotal.

    Cross-Tolerances

    psychedelic phenethylamines
    tryptamines
    lysergamides

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 25CN-NBOH with another substance

    25CN-NBOH's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 25CN-NBOH there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "25CN-NBOH (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    25CN-NBOH
    Unit
    µg
    Description 
    25CN-NBOH
Source: SubstanceSearch (substancesearch.com)

Buccal dose (µg): threshold 50-100 · light 100-300 · common 300-800 · strong 800-1200 · heavy 1200+
Sublingual dose (µg): threshold 50-100 · light 100-300 · common 300-800 · strong 800-1200 · heavy 1200+
Insufflated dose (µg): threshold 20-50 · light 50-150 · common 150-400 · strong 400-700 · heavy 700+

Buccal duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 3-5h · total 4.67-9.5h · after-effects 12h
Sublingual duration: onset 10-30m · come-up 0.5-1h · peak 1-3h · offset 3-5h · total 4.67-9.5h · after-effects 12h
Insufflated duration: onset 2-5m · come-up 15-30m · peak 1-3h · offset 3-5h · total 4.28-8.58h · after-effects 12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 550 µg (Buccal).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.