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25D-NBOMe Stats & Data

Psychedelic Research-chemical

25d N-bomb 2c-d-nbome Nbome-2c-d Divination

NPS DataHub

MW315.41

FormulaC19H25NO3

CAS1354632-02-2

IUPAC2-(2,5-dimethoxy-4-methylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine

SMILESCOc1ccccc1CNCCc1cc(OC)c(C)cc1OC

InChIKeyUTVHBNXCFSATDB-UHFFFAOYSA-N

Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen

Chemical Class Phenethylamine

Psychoactive Class Psychedelic

Receptor Profile

Receptor Actions

Agonists

5-HT2A receptor agonist (partial)

5-HT2B receptor agonist

5-HT2C receptor agonist

Adrenergic alpha-1 receptor agonist

History & Culture

25D-NBOMe is a derivative of the phenethylamine psychedelic 2C-D, created through the addition of an N-benzyl methoxy group to the parent compound. The substance emerged on the designer drug market around 2010, appearing for sale online before formal scientific characterization had been completed. It was first described in the scientific literature by 2012, with subsequent research by Martin Hansen and colleagues in 2014 examining the structure-activity relationships of N-benzyl phenethylamines and establishing 25D-NBOMe's activity profile as a potent 5-HT2A receptor agonist. The substance acquired the street name "divination" and became part of the broader NBOMe series that proliferated through online research chemical vendors in the early 2010s. Like other members of this chemical class, 25D-NBOMe had no documented history of human use prior to its appearance as a designer drug, and its emergence as a recreational substance preceded systematic research into its effects and safety profile. This pattern of market availability outpacing scientific understanding has been characteristic of the NBOMe compound series more broadly.

Subjective Effect Notes

physical: The physical effects of 25D-NBOMe can be broken down into several components which progressively intensify proportional to dosage.

cognitive: The cognitive effects of 25D-NBOMe are remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout moderate to high doses. At heavy doses, however, mild cognitive alterations become present; this dose seems to be lower in proportion to physical effects when compared to 25I-NBOMe.

Effect Profile

Curated + 12 Reports

Psychedelic 8.0

Strong visuals, auditory effects, body load, and headspace

Visual Intensity×3

Headspace Depth×3

Auditory Effects×1

Body Load / Somatic Effects×1

Based on reports from:

Erowid Experience Reports PsychonautWiki 25D-NBOMe

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Experience Report Analysis

Erowid

12 Reports

2011–2016 Date Range

10 With Age Data

16 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid

Effects aggregated from 12 experience reports (12 Erowid)

12 Reports

16 Effects Detected

8 Positive

5 Adverse

3 Neutral

Effect Sentiment Distribution

Confidence Distribution

Positive Effects 8

Color Enhancement 75.0% 70%

Music Enhancement 58.3% 70%

Focus Enhancement 50.0% 70%

Body High 50.0% 70%

Empathy 41.7% 70%

Tactile Enhancement 33.3% 70%

Introspection 33.3% 70%

Stimulation 25.0% 70%

Adverse Effects 5

Anxiety 41.7% 70%

Increased Heart Rate 33.3% 70%

Muscle Tension 25.0% 70%

Confusion 25.0% 70%

Thought Loops 25.0% 70%

Real-World Dose Distribution

62K Doses

From 11 individual dose entries

Sublingual (n=6)

Median: 1.6mg 25th: 1.15mg 75th: 1.9mg 90th: 2.6mg

mg/kg median: 0.026 mg/kg 75th: 0.03

Form / Preparation

Most common forms and preparations reported

Redose Patterns

Redosing behavior across 10 reports

0.0% Redosed

1.0 Avg Doses

Read full reports on Erowid →

Legal Status

Country	Status	Notes
Austria	Illegal (NPSG)	Controlled under the Neue-Psychoaktive-Substanzen-Gesetz (New Psychoactive Substances Act). Possession, production, and sale are prohibited.
Brazil	Illegal	Listed as a controlled substance under Portaria SVS/MS nº 344. Possession, production, and sale are prohibited.
Canada	Schedule III (CDSA)	Considered a Schedule III substance under the Controlled Drugs and Substances Act as a derivative of 2,5-dimethoxyphenethylamine.
China	Controlled	Designated as a controlled substance as of October 2015.
Finland	Scheduled	Listed in the government decree on prohibited psychoactive substances in consumer markets.
Germany	Controlled (NpSG)	Regulated under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since November 26, 2016. Production, import for distribution, administration to others, and trading are criminal offenses. Possession is prohibited but not subject to criminal penalty.
Japan	Controlled	Designated as a controlled substance effective March 25, 2015.
Latvia	Schedule I	Classified as a Schedule I controlled substance under national drug legislation.
Sweden	Schedule I	Added to Schedule I (substances without recognized medical use) as of August 1, 2013, as published by the Medical Products Agency in regulation LVFS 2013:15.
Switzerland	Controlled (Verzeichnis E)	Specifically named as a controlled substance under Verzeichnis E of the Swiss narcotics scheduling system.
Turkey	Illegal	Classified as a controlled drug. Possession, production, supply, and importation are prohibited.
United Kingdom	Class A	Controlled as a Class A substance under the Misuse of Drugs Act 1971 via the N-benzylphenethylamine catch-all clause. Initially placed under a Temporary Class Drug Order on June 10, 2013 before permanent scheduling.
United States	Unscheduled	Not specifically scheduled at the federal or state level. However, prosecution under the Federal Analogue Act may be possible when sold for human consumption due to structural and functional similarity to the controlled substance 2C-D.

References

Data Sources

Cited References

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