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    25I-NBMD molecular structure

    25I-NBMD Stats & Data

    Cimbi-29 Nbmd-2c-i
    NPS DataHub
    MW441.27
    FormulaC18H20INO4
    CAS919797-25-4
    IUPACN-(1,3-benzodioxol-4-ylmethyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine
    SMILESCOc1cc(CCNCc2cccc3OCOc23)c(OC)cc1I
    InChIKeyNJNMIPDEUMTYNV-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic
    Half-Life Human data scarce; rat microsome studies suggest 2 – 3 h apparent half-life, with subjective effects lasting longer due to active metabolites.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial, potent, Ki 0.049 nM)
    5-HT2B receptor agonist (cardiotoxic)

    History & Culture

    25I-NBMD was discovered in 2006 by a research team at Purdue University led by David Nichols. The compound is a derivative of the phenethylamine hallucinogen 2C-I, developed as part of ongoing investigations into serotonin receptor pharmacology. The related compound 25B-NBMD, the 4-bromo analogue, has been utilized in molecular dynamics studies to investigate the structural conformation of the 5-HT2A receptor. These N-benzyl derivatives of the 2C-x series were primarily developed as research tools for understanding receptor-ligand interactions rather than for recreational or therapeutic applications.

    Effect Profile

    Curated
    Psychedelic 6.6

    Strong visuals with moderate auditory effects and body load, mild headspace

    Visual Intensity×3
    10
    Headspace Depth×3
    4
    Auditory Effects×1
    7
    Body Load / Somatic Effects×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Human data scarce; rat microsome studies suggest 2 – 3 h apparent half-life, with subjective effects lasting longer due to active metabolites.
    Addiction Potential
    Low. 25I-NBMD is not known to cause physical dependence; psychological habituation is possible with frequent use. Rapid tolerance limits continuous consumption.

    Tolerance Decay

    Full tolerance 0h Half tolerance 3d Baseline ~10d

    Rapid cross-tolerance with other 5‑HT2A psychedelics is expected; conservative spacing of ≥10–14 days between experiences helps restore baseline sensitivity. Data are anecdotal due to limited human studies.

    Cross-Tolerances

    LSD
    60% ●○○
    Psilocybin
    60% ●○○

    Legal Status

    Country Status Notes
    Sweden Schedule I (Narcotic Drugs Punishments Act) Classified under Swedish schedule I, which covers substances without recognized medical use. Added on January 16, 2015, through Medical Products Agency regulation LVFS 2014:11.
    United Kingdom Class A Controlled under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause. Class A substances carry the most severe penalties, with possession punishable by up to seven years imprisonment and supply offenses carrying potential life sentences.

    Harm Reduction

    drugs.wiki

    25I-NBMD is a highly-potent benzylated phenethylamine in the NBMD sub-series (N-benzodioxolylmethyl), with microgram-level active doses; sub-milligram accuracy is essential. Use volumetric dosing and avoid ‘eyeballing’; consumer 0.001 g scales are not reliable below ~10–20 mg, so dilute a known mass into a measured volume and dose by mL. NBxx blotters are often bitter and can cause local numbing; the harm-reduction maxim “if it’s bitter, it’s a spitter” reflects that LSD blotters are usually not notably bitter or numbing. Because NBxx compounds (including NBOMe) are frequently mis-sold as LSD, test your blotter: an Ehrlich-type LSD field test (or NIK LSD pouch) will turn purple for LSD but shows no reaction for NBOMe-like phenethylamines; additionally, LSD spots glow under UV whereas NBOMe spots typically do not. Insufflation of NBxx is strongly discouraged: several NBOMe medical emergencies and fatalities followed nasal dosing; apply the same caution to NBMD. Redosing can unpredictably extend duration and body-load; avoid multiple doses in one session. Mis-weighed microgram doses are the primary cause of severe NBxx incidents; start with an allergy microdose (e.g., ≤100–200 µg of a well-mixed volumetric solution), wait a full 90 minutes, then proceed cautiously. Because stimulant-like vasoconstriction and tachycardia can occur, avoid combining with stimulants or hot environments; maintain light, periodic hydration and cooling. If chest pain, extreme agitation, confusion, or seizure occurs, seek emergency help; benzodiazepines are typically used medically to control agitation and seizures with serotonergic psychedelics, but do not self-medicate to push doses higher.

    References

    Data Sources

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