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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25I-NBMD Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Cimbi-29, Nbmd-2c-i

    Psychedelic Research-chemical

    Summary TheDrug.Wiki TripSit

    25I-NBMD is a highly potent benzylated phenethylamine with a 2,3-methylenedioxy group on the N-benzyl moiety, differing structurally from NBOMe analogues. Sub-milligram accuracy is essential; use a 0.001 mg analytical balance and volumetric dosing. Vasoconstriction, tachycardia, and peripheral numbness are commonly reported.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Sublingual 800-1500ug 1500-2000ug 2000-3000ug 3000ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 15-40 min 30-60 min 1-3 hrs 2-4 hrs 1-8 hrs 4-6 hrs
    Insufflated 5-20 min 20-40 min 1-3 hrs 2-4 hrs 1-8 hrs 4-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.6
    Strong+ 7/10

    Strong visuals with moderate auditory effects and body load, mild headspace

    Visual Intensity ×3
    10
    color enhancement synesthesia drifting tracers color shifting pattern recognition enhancement
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    7
    auditory distortion synesthesia
    ⚠ Body Load / Somatic Effects ×1
    6
    vasoconstriction nausea increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25I-NBMD
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~10d

    Rapid cross-tolerance with other 5‑HT2A psychedelics is expected; conservative spacing of ≥10–14 days between experiences helps restore baseline sensitivity. Data are anecdotal due to limited human studies.

    Cross-Tolerances

    LSD
    60%
    Psilocybin
    60%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Vasoconstriction
    • Increased heart rate
    • Nausea
    • Pupil dilation
    • Insomnia
    Neutral
    • Mouth numbing
    • Dilated pupils
    • Sedation
    Positive
    • Euphoria
    • Synesthesia
    • Conceptual thinking
    • Analysis enhancement
    Negative
    • Anxiety
    • Confusion
    • Memory suppression
    • Motor control loss
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Color enhancement
    • Color shifting
    • Pattern recognition enhancement
    • Bodily lightness
    • Tactile enhancement
    • Tracers
    Neutral
    • Drifting
    • Symmetrical texture repetition
    • Spontaneous physical sensations
    • Auditory distortion

    Combinations TripSit

    Cross-Check 25I-NBMD with another substance

    25I-NBMD's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki