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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    ☠ NBOMe compounds are active at sub-milligram doses and have been linked to numerous deaths. They are frequently mis-sold as LSD. Always test substances before use.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    25P-NBOMe

    Aliases: Nbome-2c-p

    Psychedelic Research-chemical

    Summary TheDrug.Wiki TripSit

    Extremely potent compound active in the low hundreds of micrograms range. Small measurement errors can create dangerous multi-fold overdoses. Reports of intense vasoconstriction, tachycardia, hypertension, agitation, and seizures at high doses, with multiple documented fatalities in the NBOMe series.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Sublingual 250-450ug 450-700ug 700-1500ug 1500µg+
    Oral 250-450ug 450-700ug 700-1500ug 1500ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Sublingual 10-30 min 30-60 min 2-5 hrs 4-8 hrs 2-6 hrs 6.7-14.5 hrs
    Insufflated 2-10 min 15-30 min 2-5 hrs 4-8 hrs 2-6 hrs 6.3-13.7 hrs
    Oral 25-40 min - 7-14 hrs - 1-16 hrs 7.4-14.7 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.8
    Moderate 4/10

    Moderate body load with mild visuals and headspace

    Visual Intensity ×3
    5
    color enhancement color shifting brightened colour
    Headspace Depth ×3
    4
    thought connectivity time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    7
    vasoconstriction nausea muscle tension
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 25P-NBOMe
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Vasoconstriction
    • Nausea
    • Pupil dilation
    • Restlessness
    • Sweating/chills
    • Muscle tension
    • Insomnia
    Neutral
    • Body temperature fluctuations
    • Mouth numbing
    • Decreased appetite
    Positive
    • Euphoria
    • Thought connectivity
    • Empathy
    • Insight
    Negative
    • Mania
    • Anxiety
    • Paranoia
    • Afterglow or fatigue
    • Confusion
    Neutral
    • Thought acceleration
    • Time distortion
    • Change in perception
    • Ego softening
    Positive
    • Color enhancement
    • Color shifting
    • Tactile enhancement
    • Brightened colour
    • Enhanced tactile sensation
    Negative
    • Tactile suppression
    • Appetite suppression
    Neutral
    • Visual patterning
    • Spatial depth distortion
    • Closed/Open eye visuals

    Combinations TripSit

    25P-NBOMe's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki