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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2C-EF Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Summary TheDrug.Wiki

    Extremely limited human data exists for 2C-EF. Start with low doses and verify substance identity via reagent testing or spectroscopy. Avoid combining with serotonergic agents or lithium.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 4-8mg 8-12mg 12-16mg 16mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 0.5-2 hrs 2-4 hrs 4-8 hrs 1-3 hrs 8-14 hrs

    Effect Profile

    8 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.8
    Strong 6/10

    Strong visuals with moderate body load, mild headspace

    Visual Intensity ×3
    10
    visual geometry color enhancement drifting tracers pattern recognition enhancement color shifting +1 more
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    0
    Body Load / Somatic Effects ×1
    6
    nausea muscle tension increased heart rate

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Pattern inferred from general 5‑HT2A psychedelic tolerance: acute near‑complete tolerance same day; partial recovery over ~3–7 days; baseline by ~1–2 weeks. Data quality: anecdotal/analogy.

    Effects Erowid

    Aggregated from 8 Erowid experience reports

    Positive Effects 7

    Euphoria 87.5% 70%
    Color Enhancement 62.5% 70%
    Empathy 62.5% 70%
    Music Enhancement 62.5% 70%
    Tactile Enhancement 50.0% 70%
    Introspection 50.0% 70%
    Stimulation 37.5% 70%

    Adverse Effects 5

    Muscle Tension 50.0% 70%
    Confusion 37.5% 70%
    Anxiety 37.5% 70%
    Jaw Clenching 37.5% 70%
    Nausea 37.5% 70%

    Combinations TripSit

    Cross-Check 2C-EF with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 7 neutral 1 cautionary visit
    Smooth as Silk and Warm Like Sunshine neutral exp #113370

    [Erowid Note: Two of two samples of material sold as 2C-EF and analyzed by Erowid's DrugsData service were actually other 2C- compounds.] 2C-EF - First Time - 7-4-2019 - "Smooth As Silk and Warm Like Sunshine" By Xorkoth I've been interested in 2C-EF ever since our dear fastandbulbous synthesized it and a few reports g...

    Xorkoth · 3 mg oral / 25 mg oral / 3 mg rectal / 2 mg insufflated
    A Gentle and Pleasant Ride neutral exp #113665

    [Erowid Note: Two of two samples of material sold as 2C-EF and analyzed by Erowid's DrugsData service were actually other 2C- compounds.] P Β– 155lb male Β– experienced with psychedelics (me) Β– 15mg 2C-EF R Β– 155lb male Β– psychedelic naΓ―ve Β– 15mg 2C-EF A Β– 100lb female Β– psychedelic naΓ―ve Β– 15mg 2C-EF B Β– 200lb male Β– ps...

    PropofolRC · 15 mg oral
    High Dose, Disappointment neutral exp #119413

    I donΒ’t usually write reviews, but since this compound has very few experience reports available, this might be useful as a guide for others. First, my background: 35 years old, male, 90 kg, I exercise regularly. Keep that in mind, because this compound feels a bit heavy on the cardiovascular side.

    kikorosan · 20 mg oral
    It's a Wonderful Night neutral exp #91746

    [Erowid Note: Two of two samples of material sold as 2C-EF and analyzed by Erowid's DrugsData service were actually other 2C- compounds.] A footnote in Pihkal reckons that 2C Β– EF would be a winner if anyone ever made it & the dosage would likely be between 12 and 24 mgs.

    zophen · 10 mg oral / 5 mg oral
    Fun and Trippy, but Not for an Indoor Rave neutral exp #118500

    Erowid Note: Two of two samples of material sold as 2C-EF and analyzed by Erowid's DrugsData service were actually other 2C- compounds.] So yesterday me and my gf went to a club and wanted to try those 2c-ef 10mg pellets from a famous clearnet vendor.

    miaoujap · 5 mg oral
    An Obscure and Beautiful Phenethylamine neutral exp #112521

    [Erowid Note: Two of two samples of material sold as 2C-EF and analyzed by Erowid's DrugsData service were actually other 2C- compounds.] 8/12/18 6:30: 3mg 2c-ef dosed orally 6:45: actually feeling slightly drowsy.

    thisisscience
    Pronounced Visuals, Time Distortion neutral exp #118300

    I reviewed several reports on lower doses of this substance, which coincided with its recent appearance in the research chemical market. Users experimented with smaller amounts but generally agreed that 20 mg would be suitable. Shulgin also speculated on a dosage range of 20-40 mg for 2C-EF.

    TrippingArthur · 20 mg oral
    The Frequency Inside Me cautionary exp #119372

    T+0:00 - Dose 20 mg 2C-EF, same batch as before. I expected something intense but manageable like last time, even though this is far beyond the typical dosing range for this psychedelic, in the back of my head I had my concerns about the safety, but since I've done this before I felt some confidence.

    InconspicuousKirk
    Bluelight 6 threads 6 neutral visit
    2c Ef First Time Smooth As Silk And Warm Like Sunshine neutral

    2C-EF - First Time - 7-4-2019 - "Smooth As Silk and Warm Like Sunshine" By Xorkoth **NOTE: I later discovered via GC/MS confirmation that this was actually a blend of 2C-C, 2C-T-2, and 2C-T-7, being sold as 2C-EF by an unscrupulous longtime vendor.

    scraped 2026-03-14
    2c Ef 7mg Seasoned Tripper Clear Serenity neutral

    My first trial with 2C-EF, as best as I can trust. Has not been sent off for testing yet but vendor has a long standing reputation spanning near a decade. Some intro stuff, if you'd like to skip, find the cat...

    scraped 2026-03-14
    2c Ef 10 Mg New Experience Its A Wonderful Night neutral

    A footnote in Pihkal reckons that 2C ?β‚¬β€œ EF would be a winner if anyone ever made it & the dosage would likely be between 12 and 24 mgs. I was told the dosage ought to be between 6 and 12 mgs which is probably about right T +O.OO 10mgs dosed in juice for me and my friend whom we?€ℒll call Kevin.

    scraped 2026-03-14
    2c Ef 14mg Experienced The Balance Of Profundity And Sensuality neutral

    2C-EF ~14 mg 12:30 Took with juice. 12:45 Some of the normal stirrings that something is going to happen. 1:00 Starting to feel some intense pleasure/body high. Head is feeling fuzzy. Very aphrodiasiac-like. 1:15 Some breathing of curtains happening. Still very pleasurable and smooth come up. No anxiety at all.

    scraped 2026-03-14
    2c Ef First Time Another Wonderful Drug Experience neutral

    Well the Autumn equinox came and I had a yearning to try a new psychedelic. Originally it was to be 4-allyloxy-3,5-dimethoxthyphenethylamine, bute fate conspired to make it not so. In the end I went with 2C-EF and lordy was it a good decision (nobody mention the sychrononicity word!~).

    scraped 2026-03-14
    2c Ef 28 Mgs 2c Ef You Up neutral

    I tried 28 mgs of 2c-ef recently, which had been lab tested and verified, and...wow! What a powerful substance! I decided on 28 mgs based off of reports and comparsons to 2c-e.

    scraped 2026-03-14

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