Summary
2C-T-2 is a potent 5-HT2A/2B/2C partial agonist with a steep dose-response curve and pronounced gastrointestinal distress. PIHKAL identifies 12-25 mg as the active range; harm reduction consensus converges on 15-22 mg oral for full effects. Sulfur-containing 2C-T compounds produce intense, sometimes uncomfortable body load with vasospasm risk, particularly via insufflation. Splitting doses over 60 minutes or dissolving in acidic juice markedly reduces nausea. Metabolism involves MAO-A/MAO-B and CYP2D6/CYP2C19; potential pharmacogenomic variability exists.
Perspectives
“I don’t feel this for fully an hour, but when I do it is quite a weight. It feels good to work it through. It is OK to be with pain. You can’t eliminate it. And it is OK to contact your deep pools of anger. And all of it stems from the lack of acknowledgment. All the macho carrying on, the fights, the wars, are ways of demanding attention, and getting even for not having had it in one’s life. I am experiencing more deeply than ever before the importance of acknowledging and deeply honoring each human being. And I was able to go through and resolve some judgments with particular persons.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 5-10mg | 10-20mg | 20-25mg | 25mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 30-90 min | 2.5-5.0 hrs | 2.0-4.0 hrs | 2.0-6.0 hrs | 5.0-10.0 hrs |
| Insufflated | 4-15 min | 15-30 min | 2.0-4.0 hrs | 1.0-2.0 hrs | 2.0-4.0 hrs | 3.0-7.0 hrs |
| Rectal | 15-30 min | 30-60 min | 2.0-4.0 hrs | 2.0-3.0 hrs | 2.0-4.0 hrs | 5.0-8.0 hrs |
Tolerance
Effects
- Stimulation
- Mental/physical stimulation
- Spontaneous tactile sensations
- Temperature regulation suppression
- Increased heart rate
- Vasoconstriction
- Nausea
- Stomach cramps
- Muscle tension
- Pupil dilation
- Restlessness
- Sweating/chills
- Insomnia
- Stomach cramp
- Diarrhea
- Decreased appetite
- Spontaneous bodily sensations
- Increased bodily temperature
- Conceptual thinking
- Analysis enhancement
- Thought connectivity
- Introspection
- Empathy
- Euphoria
- Insight
- Emotion enhancement
- Immersion enhancement
- Novelty enhancement
- Unity and interconnectedness
- Wakefulness
- Increased sense of humor
- Immersion intensification
- Anxiety
- Confusion
- Delusions
- Memory suppression
- Thought loops
- Delusion
- Time distortion
- Ego softening
- Change in perception
- Feelings of interdependent opposites
- Personal bias suppression
- Perspective alterations
- Thought acceleration
- Thought loop
- Perception of interdependent opposites
- Existential self-realization
- Emotion intensification
- Color enhancement
- Pattern recognition enhancement
- Visual geometry
- Tracers
- Bodily control enhancement
- Brightened colour
- Enhanced tactile sensation
- Acuity enhancement
- Auditory enhancement
- Colour enhancement
- Colour shifting
- Tactile enhancement
- Visual acuity enhancement
- Increased music appreciation
- Color shifting
- Auditory acuity enhancement
- Drifting
- Symmetrical texture repetition
- Spontaneous physical sensations
- Closed/Open eye visuals
- After images
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- External hallucinations
- Internal hallucinations
- Scenery slicing
- Auditory hallucination
- External hallucination
- Internal hallucination
- Autonomous entity
- Perspective hallucination
- Tactile intensification
Combinations
PiHKAL / TiHKAL
“I don’t feel this for fully an hour, but when I do it is quite a weight. It feels good to work it through. It is OK to be with pain. You can’t eliminate it. And it is OK to contact your deep pools of anger. And all of it stems from the lack of acknowledgment. All the macho carrying on, the fights, the wars, are ways of demanding attention, and getting even for not having had it in one’s life. I am experiencing more deeply than ever before the importance of acknowledging and deeply honoring each human being. And I was able to go through and resolve some judgments with particular persons.”