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    2C-T-4-NBOMe Stats & Data

    Nbome-2c-t-4
    NPS DataHub
    MW375.53
    FormulaC21H29NO3S
    CAS1354632-17-9
    IUPAC2-(2,5-dimethoxy-4-propan-2-ylsulfanylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
    SMILESCOc1ccccc1CNCCc1cc(OC)c(SC(C)C)cc1OC
    InChIKeyBOWHVFJVXBVJCU-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic
    Half-Life Unknown in humans; class resources note residual activity for ~5 h beyond the apparent end of acute effects.

    Effect Profile

    Curated
    Psychedelic 4.6

    Strong body load with moderate visuals, mild headspace and auditory effects

    Visual Intensity×3
    7
    Headspace Depth×3
    4
    Auditory Effects×1
    4
    Body Load / Somatic Effects×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; class resources note residual activity for ~5 h beyond the apparent end of acute effects.
    Addiction Potential
    Very low physical dependence; psychological habituation possible with frequent use due to rapid tolerance drop-off.

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Tolerance figures extrapolated from serotonergic psychedelic class behavior; specific 2C‑T‑4‑NBOMe data are lacking.

    Cross-Tolerances

    LSD
    70% ●○○
    Psilocybin
    70% ●○○
    Other serotonergic psychedelics
    60% ●○○

    Harm Reduction

    drugs.wiki

    1) Microgram dosing with a very steep dose–response is characteristic of NBOMes; small weighing errors or mislabeling have caused severe toxicity and deaths—use volumetric dosing and avoid exceeding ~1,500 µg total. 2) Do not assume oral inactivity: while many NBOMe freebases show poor oral bioavailability, some NBOMe salts display partial oral activity; never rely on swallowing to ‘rule out’ NBOMe. 3) If obtaining tabs purported to be LSD, use indole-sensitive reagents (Ehrlich/Hofmann) as LSD surrogates test positive while NBOMes generally do not; NBOMes on blotter commonly taste strongly bitter and can cause mouth numbness. 4) Mis-sold blotters are well-documented: NBOMes have been distributed as LSD; verify every batch before use. 5) Intranasal use markedly increases both intensity and risk (hypertension, vasoconstriction, seizures, overdose); sublingual/buccal routes are less risky comparatively; avoid snorting or use only tiny doses with long waits. 6) Pronounced peripheral vasoconstriction (cold/numb digits, tingling/blue discoloration), tachycardia, and hypertension have been reported with NBOMes; persistent or severe symptoms warrant immediate medical evaluation. 7) Seizures and rhabdomyolysis have occurred with NBOMe use; avoid co‑ingestants that lower seizure threshold (e.g., tramadol, stimulant stacks), maintain hydration, and seek urgent care if muscle pain/weakness or dark urine develops. 8) Combining NBOMes with stimulants (including amphetamines/MDMA) heightens risks of hypertensive crisis and severe vasoconstriction; avoid. 9) MAOIs can unpredictably potentiate phenethylamines; avoid this combination entirely. 10) Cannabis and dissociatives can unpredictably potentiate anxiety, disorientation, and looping on NBOMes; use caution, minimize doses, and ensure a sober sitter. 11) Physical tolerance to serotonergic psychedelics typically requires at least 1–2 weeks to normalize; frequent redosing rapidly builds tolerance while increasing body‑load. 12) Anecdotal reports suggest a relatively higher incidence of HPPD‑like symptoms after NBOMes; conservative spacing and avoiding binge patterns is prudent. 13) Typical sublingual total duration for NBOMes is 4–11 h (insufflated 3–8 h) with variable after‑effects; residual stimulation can impair sleep—plan accordingly. 14) For blotter sold as LSD: Ehrlich/Hofmann positive suggests an indole (e.g., LSD), while an NBOMe often yields no Ehrlich reaction and a strong bitter/metallic taste with oral mucosal numbing—still, reagent testing is the only reliable screen. 15) Store accurately labeled solutions/tabs in cool, dark conditions, and avoid moisture/heat to minimize degradation; always re-test old materials. 16) In emergencies (severe agitation, hyperthermia, seizures), benzodiazepines are commonly used by clinicians; do not delay seeking medical help.

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