2C-TFM - Substance Search

Summary TheDrug.Wiki

2C-TFM is the most potent simple 2C analogue, with human active doses of 3-6 mg according to Trachsel and Shulgin. It rivals DOI and DOB in receptor binding affinity (Ki ≈ 75 nM at 5-HT2A/C). Because it is usually synthesized from 2C-I, retail batches from the mid-2000s were often contaminated with ~50% unreacted 2C-I, leading to mixed effects and legal complications in jurisdictions where 2C-I is prohibited.

Dose Information TheDrug.Wiki

ROA	Light	Common	Strong	Heavy
Oral / Sublingual	1mg-2mg	-	-	-
Insufflated (Intranasal)	0.5mg-1.5mg	-	-	-

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral / Sublingual	15-30 min	30-60 min	1-3 hrs	2-3 hrs	2-6 hrs
Insufflated (Intranasal)	5-15 min	15-30 min	1-3 hrs	2-3 hrs	2-6 hrs

Effect Profile

16 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 6.6

Strong+ 7/10

Strong visuals with moderate auditory effects and body load, mild headspace

Visual Intensity ×3

10

color enhancement synaesthesia drifting tracers pattern recognition enhancement color shifting +1 more

Headspace Depth ×3

4

introspection time distortion confusion

Auditory Effects ×1

7

music enhancement synaesthesia

⚠ Body Load / Somatic Effects ×1

6

nausea muscle tension increased heart rate

Based on reports from:

Erowid Experience Reports PsychonautWiki 2C-TFM

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Effects Erowid Bluelight

Aggregated from 6 Erowid and 10 Bluelight experience reports

Positive Effects 47

Body High 70.0% 80%

Tactile Enhancement 66.7% 70%

Stimulation 62.5% 78%

Euphoria 56.2% 88%

Closed-Eye Visuals 56.2% 81%

Color Enhancement 50.0% 90%

Introspection 43.8% 73%

Visual Trails 40.0% 81%

Joy 40.0% 85%

Empathy 37.5% 85%

Focus Enhancement 31.2% 82%

Open-Eye Visuals 30.0% 83%

Music Enhancement 30.0% 93%

Clarity 30.0% 83%

Contentment 20.0% 85%

Thought Connectivity 20.0% 75%

Awe 20.0% 82%

Insight 20.0% 85%

Creativity Enhancement 20.0% 78%

Emotional Openness 20.0% 78%

Adverse Effects 8

Anxiety 31.2% 72%

Nausea 30.0% 72%

Motor Suppression 20.0% 70%

Body Load 20.0% 80%

Sweating 10.0% 85%

Tremor 10.0% 75%

Insomnia 10.0% 70%

Stomach Discomfort 10.0% 65%

Combinations TripSit

Cross-Check 2C-TFM with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

Erowid 6 reports 4 positive 2 neutral visit

Psychedelic GOAT positive exp #119126

This compound had long been on my bucket list, and Im grateful I received a sample as a gift. -->I have tried it once before today at 3mg, which was a low but pleasant dose comparable to ~15mg 2C-B HCl. It was enough to let it reveal its character a bit and I remember being impressed by the effects.

Rare but Intriguing and Worth-While positive exp #114932

Fortuitously and fortunately having been able to experience this currently still rare and almost unknown substance 2C-TFM hydrochloride, which was of high purity assessed by NMR, I wish to share a few observations and an excerpt of a report noted during a second experience with this substance.

First, Mild and Pleasant Encounter positive exp #114931

First, Mild and Pleasant Encounter With 2C-TFM Fortuitously and fortunately having been able to experience this currently still rare and almost unknown substance 2C-TFM hydrochloride, which was of high purity assessed by NMR, I share a brief summary of the effects encountered during the first experience with 2C-TFM.

Overall This Was Relaxing and Enjoyable positive exp #114562

A Few Notes on the Effects of 2C-TFM I was fortunate to be gifted this rare material by a dear friend and chemist. H-NMR analysis of the material indicated that it was of high purity. Setting: Indoors, during a summer evening. No other drugs or medications were consumed within 1 week before this session.

Of Conceivable Potentials neutral exp #114956

Prompted by two previous, precious, gratuitous and gratefully appreciated experiences occasioned via, through and with 2C-TFM characterizing the effects and qualitative nature of action at lower to moderate doses, there follows a description of a third adventure evoked by 6.5 mg of this pristine powder and an evaluatio...

First Time Trial neutral exp #91745

Set Not perfect but Ive had worse. An hours sleep the night before makes me feel sleepy Setting My House, kids due in from school busy household Im used to it T+0.00 Drink 3mgs of dissolved drug T+ 0.10 Faint perceptual changes, continue reading my book.

Bluelight 6 threads 1 positive 5 neutral visit

2c Tfm 8mg First Time Fun With Fanz Phenz And 2c Tfmz positive

2C-TFM 8mg - Fun with FANz PHENz and 2C-TFMz 2C-TFM 8mg FUN WITH FANz, PHENz and 2C-TFMz There's not much info on the web about this "newbie" phenethylamine so I thought it would be nice to write up a trip report.

2c Tfm 5mg Plugged Somewhat Experienced Finding Something Within neutral

I thought it was about time to post an experience with this fairly unknown new research chemical. I've tried it a few other times (with oral doses of 4 and 5mg respectively), which produced a mild ++ buzz peppered with obscene amount of laughter and slight visuals. It was shallow, but quite a bit of fun.

2c Tfm Second Time 4mg neutral

2C-TFM - second time - 4mg 5:50 - I eat a capsule of 4mg -tfm, i'm excited. 6:00 - Seems like I already feel something! I'm gonna hop in the shower real quick.. Its about 9pm now, friends came over, so i got off the computer. I just boosted with about 3mg held under the tongue for a while before swallowing.

2c Tfm 6mg First Time Well See Where This Goes neutral

I just took about 6mg of 2C-TFM at around 8PM (Central Time), and I could tell from the get go that I'd want to write a trip report. I will keep adding as the night progresses... +00:45 Went to Wal-Mart to get a TV-out cable for my friend M's computer so we could watch Futurama on my TV.

2c Tfm Experienced 6 5 Mgs neutral

2C-TFM Set – Not perfect but I’ve had worse. An hours sleep the night before makes me feel sleepy Setting – My House, kids due in from school – busy household – I’m used to it T+0.00 – Drink 3mgs of dissolved drug T+ 0.10 Faint perceptual changes, continue reading my book.

2c Tfm 17mg Moderately Experienced The Final Word On This Substance neutral

I've experimented with 2c-tfm enough times (four total) to get a feel for what is a fairly unknown psychedelic, and finally found a dose which seems to show all of the charcteristics of the drug (17mg of the contaminated sample which contains 2c-i, and other PEA's) If i was to compare this to any other psychedelic drug...

2C-TFM's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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2C-TFM Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 2 corroborating sources partial dose data duration data present 17 combo interactions documented classified Research-chemical dose data not in PW/TripSit (unverifiable)