Summary
2C-TFM is the most potent simple 2C analogue, with human active doses of 3-6 mg according to Trachsel and Shulgin. It rivals DOI and DOB in receptor binding affinity (Ki ≈ 75 nM at 5-HT2A/C). Because it is usually synthesized from 2C-I, retail batches from the mid-2000s were often contaminated with ~50% unreacted 2C-I, leading to mixed effects and legal complications in jurisdictions where 2C-I is prohibited. Purity must be confirmed with multi-reagent testing plus quantitative chromatography whenever possible. The compound produces an unusually clear-headed, color-saturated visual field with mild bodily stimulation and minimal vasoconstriction at doses ≤5 mg.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 1mg-2mg | - | - | - |
| Insufflated (Intranasal) | 0.5mg-1.5mg | - | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-30 min | 30-60 min | 1-3 hrs | 2-3 hrs | 2-6 hrs |
| Insufflated (Intranasal) | 5-15 min | 15-30 min | 1-3 hrs | 2-3 hrs | 2-6 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
- Mental/physical stimulation
Negative
- Pupil dilation
- Nausea
- Restlessness
- Muscle tension
- Insomnia
- Increased heart rate
- Dilated pupils
- Decreased appetite
Positive
- Euphoria
- Analysis enhancement
- Introspection
- Empathy
- Insight
Negative
- Confusion
- Memory suppression
- Anxiety
- Thought organization
- Time distortion
Positive
- Color enhancement
- Music enhancement
- Synaesthesia
- Pattern recognition enhancement
- Tracers
- Color shifting
- Enhanced tactile sensation
Negative
- Visual distortions
- Drifting
- Perspective hallucination