2C-TFM
Aliases: 2c-cf3
Summary
2C-TFM is the most potent simple 2C analogue, with human active doses of 3-6 mg according to Trachsel and Shulgin. It rivals DOI and DOB in receptor binding affinity (Ki ≈ 75 nM at 5-HT2A/C). Because it is usually synthesized from 2C-I, retail batches from the mid-2000s were often contaminated with ~50% unreacted 2C-I, leading to mixed effects and legal complications in jurisdictions where 2C-I is prohibited.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 1mg-2mg | - | - | - |
| Insufflated (Intranasal) | 0.5mg-1.5mg | - | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral / Sublingual | 15-30 min | 30-60 min | 1-3 hrs | 2-3 hrs |
| Insufflated (Intranasal) | 5-15 min | 15-30 min | 1-3 hrs | 2-3 hrs |
Effect Profile
16 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.6
Strong+
7/10
Strong visuals with moderate auditory effects and body load, mild headspace
Visual Intensity
×3
10
color enhancement
synaesthesia
drifting
tracers
pattern recognition enhancement
color shifting
+1 more
Headspace Depth
×3
4
introspection
time distortion
confusion
Auditory Effects
×1
7
music enhancement
synaesthesia
Body Load / Somatic Effects
×1
6
nausea
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Effects
Aggregated from 6 Erowid and 10 Bluelight experience reports
Positive Effects 47
Body High
70.0%
80%
Tactile Enhancement
66.7%
70%
Stimulation
62.5%
78%
Euphoria
56.2%
88%
Closed-Eye Visuals
56.2%
81%
Color Enhancement
50.0%
90%
Introspection
43.8%
73%
Visual Trails
40.0%
81%
Joy
40.0%
85%
Empathy
37.5%
85%
Focus Enhancement
31.2%
82%
Open-Eye Visuals
30.0%
83%
Music Enhancement
30.0%
93%
Clarity
30.0%
83%
Contentment
20.0%
85%
Thought Connectivity
20.0%
75%
Awe
20.0%
82%
Insight
20.0%
85%
Creativity Enhancement
20.0%
78%
Emotional Openness
20.0%
78%
Adverse Effects 8
Anxiety
31.2%
72%
Nausea
30.0%
72%
Motor Suppression
20.0%
70%
Body Load
20.0%
80%
Sweating
10.0%
85%
Tremor
10.0%
75%
Insomnia
10.0%
70%
Stomach Discomfort
10.0%
65%
Combinations
2C-TFM's nerd page
Pharmacology, chemical data, effect profiles, and more
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