Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    3-Hydroxyphenazepam

    Aliases: Hpnz, 3-hop, 3-oh-p, 3ohphenazepam, 3-ho-phenazepam, 3hophenazepam, 3-ho-p, 3hop, 3ohp, 3-oh-phenazepam

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit

    3-Hydroxyphenazepam is a potent designer benzodiazepine and active metabolite of phenazepam and cinazepam. It is 5-10 times more potent than diazepam and has diminished muscle relaxant properties compared to phenazepam while retaining strong sedative and anxiolytic effects. Recreational doses carry high risk of blackouts, amnesia, and respiratory depression, especially when combined with other CNS depressants.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 0.5-1mg 1-2mg - 2-4mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 10-60 min 30-90 min 2-6 hrs 4-8 hrs 1-36 hrs 6.7-16.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.6
    Intense 8/10

    Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    7
    motor control loss amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 3-Hydroxyphenazepam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Benzodiazepine tolerance typically develops within days of frequent use and decays over weeks after cessation. Figures are approximate, based on class-wide patterns and user reports rather than substance‑specific kinetics.

    Cross-Tolerances

    benzodiazepines
    80%
    Z-drugs
    60%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Anxiolytic
    • Muscle Relaxant
    • Physical euphoria
    Negative
    • Motor impairment
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Motor control loss
    • Emotion suppression
    • Thought deceleration
    • Analysis suppression
    • Compulsive redosing
    • Dizziness
    • Delusions of sobriety
    Positive
    • Increased music appreciation
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    3-Hydroxyphenazepam's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki