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    Disclaimer
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    3-Hydroxyphenazepam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • partial dose data
    • duration data present
    • 17 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Hpnz, 3-hop, 3-oh-p, 3ohphenazepam, 3-ho-phenazepam, 3hophenazepam, 3-ho-p, 3hop, 3ohp, 3-oh-phenazepam

    Summary dose.wiki TripSit

    3-Hydroxyphenazepam is a potent designer benzodiazepine and active metabolite of phenazepam and cinazepam. It is 5-10 times more potent than diazepam and has diminished muscle relaxant properties compared to phenazepam while retaining strong sedative and anxiolytic effects. Recreational doses carry high risk of blackouts, amnesia, and respiratory depression, especially when combined with other CNS depressants.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 0.5-1mg 1-2mg - 2-4mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 10-60 min 30-90 min 2-6 hrs 4-8 hrs 1-36 hrs 10-24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.6
    Intense 8/10

    Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    Motor / Cognitive Impairment ×1
    7
    motor control loss amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3-Hydroxyphenazepam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    3-Hydroxyphenazepam
    Unit
    mg
    Description
    3-Hydroxyphenazepam
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): light 0.5-1 Β· common 1-2 Β· heavy 2-4+
    
    Oral duration: onset 0.17-1h Β· come-up 0.5-1.5h Β· peak 2-6h Β· offset 4-8h Β· total 10-24h Β· after-effects 1-36h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~60d

    Benzodiazepine tolerance typically develops within days of frequent use and decays over weeks after cessation. Figures are approximate, based on class-wide patterns and user reports rather than substance‑specific kinetics.

    Cross-Tolerances

    Effects dose.wiki

    Positive
    • Muscle relaxation
    • Anxiolytic
    • Muscle Relaxant
    • Physical euphoria
    Negative
    • Motor impairment
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Amnesia
    • Motor control loss
    • Emotion suppression
    • Thought deceleration
    • Analysis suppression
    • Compulsive redosing
    • Dizziness
    • Delusions of sobriety
    Positive
    • Increased music appreciation
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Cross-Check 3-Hydroxyphenazepam with another substance

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