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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3-MeO-PCE Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 5 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Tentative
    • classified Research-chemical

    Aliases: Methoxieticyclidine, Methoxyieticyclidine, 3meopce

    Dissociative Research-chemical

    Summary TheDrug.Wiki TripSit PsychonautWiki

    3-MeO-PCE is a potent dissociative with a significantly higher risk of inducing mania, delusions, and psychosis than other dissociatives such as ketamine or MXE. It is extremely stimulating and carries a pronounced tendency toward compulsive redosing, especially when smoked or vaporized. Due to its high potency, volumetric liquid dosing is strongly recommended.

    Perspectives

    “Wow this is my new favorite dissociative, out of the many many I have tried. It’s highly euphoric, but also very deep and psychedelic. It doesn’t feel like it impairs me in any way, rather it improves my function, and doesn’t have the delusional sort of mania that 3-MeO-PCP carries.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 4-8mg 8-15mg 15-25mg 25mg+
    Insufflated 3-6mg 6-12mg 12-20mg 20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 1-2 hrs 2-3 hrs 1-2 hrs 4-48 hrs 3-5 hrs
    Insufflated 3-15 min 45-90 min 1.5-2 hrs 45-60 min 4-48 hrs 3-5 hrs

    Effect Profile

    24 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 24 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.3
    Strong 6/10

    Strong dissociative depth, mania, and motor impairment with moderate insight

    Dissociative Depth ×3
    10
    consciousness disconnection depersonalization derealization physical disconnection cognitive disconnection visual disconnection +6 more
    ⚠ Mania / Compulsion ×1
    10
    mania compulsive redosing delusions delusions of sobriety disinhibition stimulation
    Insight / Novel Thought ×2
    7
    conceptual thinking unity and interconnectedness creativity enhancement
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression spatial disorientation visual disconnection double vision
    Based on reports from:
    Effect Index Everything Happening Around Me Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 3-MeO-PCE
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Anecdotal pattern: rapid tolerance build with consecutive-day use; partial recovery over 1–2 weeks, baseline in ~2–4 weeks. Cross-tolerance across arylcyclohexylamines is commonly reported. Data quality: anecdotal.

    Cross-Tolerances

    Other arylcyclohexylamines (e.g., 3-MeO-PCP, ketamine, PCP)
    70%

    Effects Erowid

    Aggregated from 24 Erowid experience reports

    Positive Effects 11

    Stimulation 66.7% 70%
    Euphoria 58.3% 70%
    Music Enhancement 54.2% 70%
    Color Enhancement 37.5% 70%
    Body High 29.2% 70%
    Tactile Enhancement 29.2% 70%
    Focus Enhancement 29.2% 70%
    Empathy 20.8% 70%
    Introspection 12.5% 70%
    Pain Relief 12.5% 70%
    Creativity Enhancement 12.5% 70%

    Adverse Effects 7

    Anxiety 50.0% 70%
    Confusion 37.5% 70%
    Psychosis 29.2% 70%
    Motor Impairment 25.0% 70%
    Headache 25.0% 70%
    Memory Suppression 20.8% 70%
    Increased Heart Rate 12.5% 70%

    Combinations TripSit

    Cross-Check 3-MeO-PCE with another substance

    Trip Reports Effect Index

    Everything Happening Around Me nervewing

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 2 positive 4 neutral 2 cautionary visit
    It's Magic positive exp #110250

    This was a truly magical experience with 3-MeO-PCE (3-Methoxy-Eticyclidine). It was beautiful enough to motivate me to write my first exhaustive trip report, so here goes nothing.

    W · 15 mg rectal / 10 mg rectal
    Liquid Bounce positive exp #109680

    Normally I read experience reports, but this substance has only a few other reports. I am not that great of a writer, and its so hard to put my sensations into words. I love dissociates, had it not been for my love affair with opiates, I might not have ever touched another class of drug.

    disaster_line · 16 mg insufflated
    Disintegration neutral exp #114506

    [Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.

    lucifer speaks · 40 mg oral
    The Dancing Electronic Terracotta Army neutral exp #110490

    The dancing electronic Terracotta Army After a few lovely past experiences with 3-MeO-PCE by myself in quiet settings I decided to go dance to some techno music on it. A somewhat well known DJ was playing a venue in my hometown and some friends and I decided to go.

    W · 12.5 mg insufflated / 12.5 mg insufflated / 12.5 mg insufflated / 12.5 mg insufflated
    Lamictal Did Not Reduce Intensity neutral exp #113048

    In addition to the daily testosterone gel I apply, I take 10 mg aripiprazole and 100 mg lamotrigine nightly, and 150 mg bupropion in the mornings. I have experience with ketamine, 3-MeO-PCP, 3-MeO-PCE, 3-HO-PCP, 3-HO-PCE, and memantine.

    tragicomedy · 25 mg oral / 17 mg rectal / repeated smoked / 10 mg rectal
    Madness Mania at a Moderate High Dose neutral exp #109936

    I received a small sample of a relatively novel substance to try, 3-MeO-PCE, and plugged (rectal administration in a gelatin capsule). IΒ’m a tall, 200lb male with a very steady and calm temperament.

    EC · 28 mg rectal / 20 mg oral / 2 mg
    Five Days Awake With Insane Hallucinations cautionary exp #114463

    [Erowid Note: The doses described in this report are potentially life threatening. The amount taken is beyond a heavy dose and could pose serious health risks or result in unwanted, extreme effects. Doses such as this have been known to cause hospitalizations and/or deaths.

    theAngryLittleBunny · 3-MEO-PCE · 30 mg insufflated / 10 mg insufflated / 1 mg oral / 2.5 mg oral
    Temporary Vegetable State cautionary exp #108709

    Earlier that night: 140mg 4-FMA (oral), speed (insufflated), GHB (oral) T- (3-5) hours: 200mg 3-MMC (oral) T+ 0 (around 7am Sunday morning): 160mg 3-MEO-PCE (oral) T+ 10min: 5mg Etizolam, 0.5mg Clonazolam (oral) T+ ?: redoses of Etizolam and Clonazolam (oral) This is a report that I'm typing for other people who have t...

    anonymous · 3-MEO-PCE · 160 mg oral / 5 mg oral / 0.5 mg oral / oral

    Bluelight Reference Guide Bluelight

    Dissociatives The Big & Dandy 3-MeO-PCE Thread

    Also called: Methoxieticyclidine 3-MEO-PCE (the non-ketone version of Methoxetamine) is due to hit the UK next week. Thoughts? I figure this is it:

    Read full thread on Bluelight β†’
    3-MeO-PCE's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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