3-MeO-PCE - Substance Search

Summary TheDrug.Wiki TripSit PsychonautWiki

3-MeO-PCE is a potent dissociative with a significantly higher risk of inducing mania, delusions, and psychosis than other dissociatives such as ketamine or MXE. It is extremely stimulating and carries a pronounced tendency toward compulsive redosing, especially when smoked or vaporized. Due to its high potency, volumetric liquid dosing is strongly recommended.

Perspectives

“Wow this is my new favorite dissociative, out of the many many I have tried. It’s highly euphoric, but also very deep and psychedelic. It doesn’t feel like it impairs me in any way, rather it improves my function, and doesn’t have the delusional sort of mania that 3-MeO-PCP carries.”

— Nervewing, nervewing.blogspot.com 20 mg intranasal

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	4-8mg	8-15mg	15-25mg	25mg+
Insufflated	3-6mg	6-12mg	12-20mg	20mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	30-90 min	1-2 hrs	2-3 hrs	1-2 hrs	4-48 hrs	3-5 hrs
Insufflated	3-15 min	45-90 min	1.5-2 hrs	45-60 min	4-48 hrs	3-5 hrs

Effect Profile

24 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 24 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Dissociative 6.3

Strong 6/10

Strong dissociative depth, mania, and motor impairment with moderate insight

Dissociative Depth ×3

10

consciousness disconnection depersonalization derealization physical disconnection cognitive disconnection visual disconnection +6 more

⚠ Mania / Compulsion ×1

10

mania compulsive redosing delusions delusions of sobriety disinhibition stimulation

Insight / Novel Thought ×2

7

conceptual thinking unity and interconnectedness creativity enhancement

⚠ Motor / Sensory Impairment ×1

10

motor control loss physical disconnection tactile suppression spatial disorientation visual disconnection double vision

Based on reports from:

Effect Index Everything Happening Around Me Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 3-MeO-PCE

Tolerance

Build-up develops with repeated use over days to weeks

Reset 2–4 weeks for noticeable reduction

Tolerance Decay

Full tolerance 3d Half tolerance 7d Baseline ~14d

Anecdotal pattern: rapid tolerance build with consecutive-day use; partial recovery over 1–2 weeks, baseline in ~2–4 weeks. Cross-tolerance across arylcyclohexylamines is commonly reported. Data quality: anecdotal.

Cross-Tolerances

Other arylcyclohexylamines (e.g., 3-MeO-PCP, ketamine, PCP)

70%

Effects Erowid

Aggregated from 24 Erowid experience reports

Positive Effects 11

Stimulation 66.7% 70%

Euphoria 58.3% 70%

Music Enhancement 54.2% 70%

Color Enhancement 37.5% 70%

Body High 29.2% 70%

Tactile Enhancement 29.2% 70%

Focus Enhancement 29.2% 70%

Empathy 20.8% 70%

Introspection 12.5% 70%

Pain Relief 12.5% 70%

Creativity Enhancement 12.5% 70%

Adverse Effects 7

Anxiety 50.0% 70%

Confusion 37.5% 70%

Psychosis 29.2% 70%

Motor Impairment 25.0% 70%

Headache 25.0% 70%

Memory Suppression 20.8% 70%

Increased Heart Rate 12.5% 70%

Combinations TripSit

Trip Reports Effect Index

Everything Happening Around Me nervewing

3-MeO-PCE's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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