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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3,4-CFPP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 3,4-cfp, 3cl-4f-p, Kleferein, 3-chloro-4-fluoro-piperein

    Stimulant Research-chemical

    Summary dose.wiki

    Very little pharmacological or toxicological data exists. Based on structural similarity to mCPP and TFMPP, this compound likely acts as a non-selective serotonin receptor agonist and serotonin releaser. These phenylpiperazines are notorious for producing nausea, migraines, anxiety, and dysphoria rather than euphoria.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges are compiled from scattered user reports and by analogy to related phenylpiperazines; no formal human data exist. Always allergy test (≈1–2 mg) and use a calibrated milligram scale. Expect more nausea and headache than with classical empathogens; redosing tends to increase adverse effects disproportionately. Evidence quality: anecdotal. Phenylpiperazines can be irritating to mucosa and more likely to cause headaches and nausea when snorted; TFMPP/pFPP reports specifically note sore throat/nasal irritation. Prefer oral route for lower adverse-event rates. Evidence: user reports on piperazines; no CFPP-specific data. Evidence quality: anecdotal. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 20-50mg 50-100mg 100-150mg 150mg+
    Insufflated 5-15mg 15-40mg 40-70mg 70mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1-3 hrs 1-2 hrs 1-6 hrs 2.33-6 hrs
    Insufflated 5-15 min 1-3 hrs 1-2 hrs 1-6 hrs 2.08-5.25 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 4.0
    Moderate 4/10

    Moderate stimulation with mild euphoria, low empathy and sensory enhancement

    Empathy / Social Openness ×3
    3
    empathy enhancement
    Euphoria / Mood Elevation ×2
    5
    euphoria mood lift
    Stimulation ×1
    6
    physical stimulation restlessness teeth grinding
    Sensory Enhancement ×1
    3
    color enhancement
    Stimulant 3.4
    Light+ 3/10

    Strong anxiety/jitters with mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    physical stimulation alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    8
    anxiety restlessness teeth grinding
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3,4-CFPP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3,4-CFPP (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3,4-CFPP
    Unit
    mg
    Description 
    3,4-CFPP
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 20 · light 20-50 · common 50-100 · strong 100-150 · heavy 150+
Insufflated dose (mg): threshold 5 · light 5-15 · common 15-40 · strong 40-70 · heavy 70+

Oral duration: onset 0.33-1h · peak 1-3h · offset 1-2h · total 2.33-6h · after-effects 1-6h
Insufflated duration: onset 5-15m · peak 1-3h · offset 1-2h · total 2.08-5.25h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects dose.wiki

    Positive
    • Physical stimulation
    Negative
    • Restlessness
    • Insomnia
    • Teeth grinding
    • Pupil dilation
    • Increased perspiration
    • Temperature regulation suppression
    • Nausea
    • Headache
    Positive
    • Mood lift
    • Empathy enhancement
    • Alertness enhancement
    • Euphoria
    Negative
    • Anxiety
    • Dysphoria
    • Drowsiness
    Neutral
    • Talkativeness
    • Feelings of Impending Doom
    Positive
    • Tracers
    • Color Enhancement
    Negative
    • Light sensitivity
    • Appetite Suppression
    • Decreased Libido
    • Dehydration
    Neutral
    • Visual distortions
    • Closed-Eye Visuals
    • Visual Drifting
    • Perception of Bodily Heaviness

    Combinations

    Cross-Check 3,4-CFPP with another substance

    3,4-CFPP's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki