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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3,4-TMPD

    Aliases: 3,4-tmp, 3,4-trimethylenepentedrone

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    Very little human data exist. All dosage estimates are extrapolated from closely related cathinones such as pentedrone and pentylone, a handful of Reddit and Bluelight reports, and forensic potency modelling. Users describe rapid, clean stimulation with mild empathogenic warmth, stronger on dopamine and norepinephrine than serotonin.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 30-60 min 1-2.5 hrs 1-2 hrs 1-3 hrs
    Insufflated 5-30 min 15-30 min 1-2.5 hrs 1-2 hrs 1-3 hrs
    Rectal 10-20 min 20-40 min 1-2.5 hrs 1-2 hrs 1-3 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 3.7
    Moderate 4/10

    Moderate stimulation and sensory enhancement with low euphoria and empathy

    Empathy / Social Openness ×3
    2
    enhanced sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 4.4
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation, euphoria, and focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria increased motivation
    Focus / Productivity ×2
    5
    focus enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction muscle tension sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 3,4-TMPD
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Teeth grinding
    • Muscle tension
    • Increased perspiration
    • Vasoconstriction
    • Insomnia
    • Increased heart rate
    • Pupil dilation
    • Sweating
    Neutral
    • Decreased appetite
    Positive
    • Euphoria
    • Enhanced sociability
    • Increased motivation
    • Focus enhancement
    • Wakefulness
    Negative
    • Anxiety
    • Cognitive fatigue
    • Depression
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Mild tactile enhancement
    • Tactile enhancement
    • Increased libido
    • Increased music appreciation
    • Tracers
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition

    Combinations TripSit

    3,4-TMPD's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki