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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    3,4-TMPD Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 3,4-tmp, 3,4-trimethylenepentedrone

    Stimulant Research-chemical

    Summary dose.wiki

    Very little human data exist. All dosage estimates are extrapolated from closely related cathinones such as pentedrone and pentylone, a handful of Reddit and Bluelight reports, and forensic potency modelling. Users describe rapid, clean stimulation with mild empathogenic warmth, stronger on dopamine and norepinephrine than serotonin.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Dose ranges are compiled primarily from community user reports and extrapolation from closely related cathinones (e.g., pentedrone/pentylone). Individual sensitivity varies widely with NPS stimulants; start low and avoid rapid redosing. Insufflation of cathinones is frequently described as caustic and irritating; use extreme caution, minimize frequency, and rinse nasal passages with isotonic saline after use. Multiple community reports of harshness exist for similar cathinones/pyrovalerones. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 15-30mg 30-60mg 60-90mg 90mg+
    Insufflated 10-20mg 20-40mg 40-60mg 60mg+
    Rectal 12-25mg 25-45mg 45-70mg 70mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-30 min 30-60 min 1-2.5 hrs 1-2 hrs 1-3 hrs 2.75-6 hrs
    Insufflated 5-30 min 15-30 min 1-2.5 hrs 1-2 hrs 1-3 hrs 2.33-5.5 hrs
    Rectal 10-20 min 20-40 min 1-2.5 hrs 1-2 hrs 1-3 hrs 2.5-5.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 3.7
    Moderate 4/10

    Moderate stimulation and sensory enhancement with low euphoria and empathy

    Empathy / Social Openness ×3
    2
    enhanced sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 4.4
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation, euphoria, and focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria increased motivation
    Focus / Productivity ×2
    5
    focus enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction muscle tension sweating
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 3,4-TMPD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "3,4-TMPD (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    3,4-TMPD
    Unit
    mg
    Description 
    3,4-TMPD
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10-15 · light 15-30 · common 30-60 · strong 60-90 · heavy 90+
Insufflated dose (mg): threshold 5-10 · light 10-20 · common 20-40 · strong 40-60 · heavy 60+
Rectal dose (mg): threshold 7-12 · light 12-25 · common 25-45 · strong 45-70 · heavy 70+

Oral duration: onset 15-30m · come-up 0.5-1h · peak 1-2.5h · offset 1-2h · total 2.75-6h · after-effects 1-3h
Insufflated duration: onset 5-30m · come-up 15-30m · peak 1-2.5h · offset 1-2h · total 2.33-5.5h · after-effects 1-3h
Rectal duration: onset 10-20m · come-up 20-40m · peak 1-2.5h · offset 1-2h · total 2.5-5.5h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 45 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects dose.wiki

    Positive
    • Stimulation
    Negative
    • Teeth grinding
    • Muscle tension
    • Increased perspiration
    • Vasoconstriction
    • Insomnia
    • Increased heart rate
    • Pupil dilation
    • Sweating
    Neutral
    • Decreased appetite
    Positive
    • Euphoria
    • Enhanced sociability
    • Increased motivation
    • Focus enhancement
    • Wakefulness
    Negative
    • Anxiety
    • Cognitive fatigue
    • Depression
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Mild tactile enhancement
    • Tactile enhancement
    • Increased libido
    • Increased music appreciation
    • Tracers
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition

    Combinations

    Cross-Check 3,4-TMPD with another substance

    3,4-TMPD's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki