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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-AcO-DMT

    Aliases: 4-aco, Psilacetin, 4-acetoxy-dmt, O-acetylpsilocin, Synthetic mushrooms, 4acodmt

    Psychedelic Research-chemical

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    4-AcO-DMT is a synthetic psychedelic that rapidly converts to psilocin in the body, producing effects nearly identical to psilocybin mushrooms but with reportedly less nausea and body load. Effects are highly dose-dependent and can range from gentle mushroom-like experiences at low-moderate doses to intense DMT-like states at higher doses. Not recommended for individuals with personal or family history of psychosis.

    Perspectives

    “Beautiful life changing trip. Cannot articulate how beautiful it was. The lessons I thought I learned would end up not sticking, as nothing ever does. It turns out I am much less in control of things than I had thought.”

    “It was a pleasant ride, despite my poor condition. I look forward to further experimentation and perhaps a deeper and more spiritually meaningful trip.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 7.5-15mg 15-25mg 25-45mg 45mg+
    Insufflated 10-15mg 15-25mg 25-50mg 50mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-60 min 30-90 min 2-3 hrs 1-2 hrs 2-8 hrs 6-8 hrs
    Insufflated 1-15 min 15-30 min 1.5-3 hrs 1-2 hrs 2-6 hrs 3-5 hrs

    Effect Profile

    349 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 275 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.8
    Intense+ 9/10

    Strong visuals, headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    external hallucinations internal hallucinations colour enhancement autonomous entities tracers synaesthesia +10 more
    Headspace Depth ×3
    10
    conceptual thinking thought connectivity personal meaning enhancement feelings of interdependent opposites subconscious communication multiple thought streams +9 more
    Auditory Effects ×1
    10
    auditory distortion auditory enhancement auditory hallucinations auditory hallucination synaesthesia
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression teeth grinding
    Based on reports from:
    Effect Index The Blizzard Effect Index My Triumphant Return Effect Index A Relaxing Morning in the Park Effect Index My One Bad Trip Effect Index Thawing
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1d Half tolerance 5d Baseline ~14d

    Empirical rules of thumb from community data: substantial tolerance is present for several days after a dose; near‑baseline returns in roughly 10–14 days. Repeated redosing within a session provides diminishing returns and more side‑effects. Data quality is anecdotal; no controlled human tolerance studies for 4‑AcO‑DMT specifically.

    Cross-Tolerances

    Psilocybin/Psilocin
    80%
    LSD & other serotonergic psychedelics
    60%

    Effects Erowid Bluelight

    Aggregated from 275 Erowid and 74 Bluelight experience reports

    Positive Effects 73

    Color Enhancement 54.7% 87%
    Euphoria 50.8% 91%
    Music Enhancement 48.3% 88%
    Empathy 42.5% 86%
    Closed-Eye Visuals 35.4% 90%
    Introspection 30.7% 87%
    Tactile Enhancement 28.3% 75%
    Focus Enhancement 26.8% 82%
    Joy 26.0% 87%
    Insight 24.0% 89%
    Ego Dissolution 23.7% 85%
    Awe 22.0% 88%
    Open-Eye Visuals 19.7% 86%
    Patterning 18.0% 89%
    Thought Acceleration 18.0% 81%
    Bliss 18.0% 87%
    Body High 17.2% 85%
    Warping 16.0% 86%
    Love 16.0% 89%
    Geometric Imagery 16.0% 87%

    Adverse Effects 46

    Anxiety 56.3% 86%
    Confusion 40.9% 86%
    Nausea 32.0% 82%
    Body Load 22.0% 76%
    Dysphoria 16.0% 81%
    Memory Suppression 14.2% 76%
    Fear 12.0% 90%
    Thought Loops 11.7% 81%
    Muscle Tension 11.3% 70%
    Panic 10.0% 88%
    Paranoia 10.0% 81%
    Depersonalization 10.0% 77%
    Sadness 8.0% 80%
    Focus Suppression 8.0% 78%
    Thought Disorganization 8.0% 84%
    Psychosis 8.0% 70%
    Headache 7.3% 70%
    Increased Heart Rate 6.9% 70%
    Dry Mouth 6.0% 77%
    Temporal Disorientation 6.0% 87%

    Combinations TripSit

    Trip Reports Effect Index

    The Blizzard nervewing My Triumphant Return Greg A Relaxing Morning in the Park Greg My One Bad Trip Greg Thawing nervewing Surrender Kaylee I Begged the Shroom Aliens to Kill Me Oscarette Permanent All-Encompassing States of Unity and Interconnectedness Oscarette Relationship Problems Oscarette A Profound Sense of Oneness Oscarette I Saw an Angry God-Like Figure Made of Clouds Glaring Down at Me Oscarette This Is Disgusting and Shameful nervewing I Was Overcome with Feelings About My Family Oscarette Extremely Reckless Drug Abuse with My Girlfriend Oscarette
    4-AcO-DMT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 Bluelight 📖 The Drug Users Bible