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    4-Chloromethamphetamine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented

    Stimulant

    Summary

    4-Chloromethamphetamine is a stimulant amphetamine. Reported effects include euphoria, color enhancement, time distortion, and wakefulness. Limited data is available on its dosage and safety profile.

    Dose Information Drugs.Wiki

    Dose basis. Ranges extrapolated from limited human anecdotes and structural analogy; there is no validated human dosing literature. Because 4-CMA may form the potent serotonergic neurotoxin 4-CA (para-chloroamphetamine), any use carries disproportionate risk; avoid redosing and treat all amounts as potentially hazardous. Evidence basis: PCA’s robust serotonergic neurotoxicity in animals; 4-CMA is the N-methyl analog likely subject to N-dealkylation similar to methamphetamine→amphetamine. Anecdotal reports and community warnings only; no clinical guidance exists. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-30mg 30-45mg 45mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1-3 hrs 2-4 hrs 2-24 hrs 3-7 hrs

    Effect Profile

    class estimate

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 6 other substances of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.5
    Strong 6/10

    Strong euphoria and anxiety/jitters with moderate focus and stimulation

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    10
    physical euphoria euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Chloromethamphetamine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Chloromethamphetamine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Chloromethamphetamine
    Unit
    mg
    Description 
    4-Chloromethamphetamine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 · light 5-15 · common 15-30 · strong 30-45 · heavy 45+

Oral duration: onset 0.33-1h · peak 1-3h · offset 2-4h · total 3-7h · after-effects 2-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 22.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 2d Half tolerance 14d Baseline ~28d

    Quantitative tolerance data for 4-CMA do not exist. Timeline above is a conservative, low-confidence scaffold extrapolated from stimulant tolerance patterns and severe serotonergic disruption seen with PCA-class agents; prioritize long spacing (≥4 weeks) after any exposure to allow recovery. Data quality: anecdotal/theoretical.

    Cross-Tolerances

    Amphetamine derivatives (general)
    30%
    Other serotonergic releasers (e.g., MDMA/MDA)
    40%

    Effects

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Increased heart rate
    • Vasoconstriction
    • Insomnia
    • Teeth grinding
    • Pupil dilation
    • Nausea
    • Increased perspiration
    Neutral
    • Decreased appetite
    Positive
    • Alertness enhancement
    • Euphoria
    • Wakefulness
    • Motivation enhancement
    • Cognitive euphoria
    • Focus enhancement
    Negative
    • Anxiety
    Neutral
    • Talkativeness
    • Time distortion
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    • Enhanced tactile sensation
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Drifting

    Combinations

    Cross-Check 4-Chloromethamphetamine with another substance

    4-Chloromethamphetamine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki