4-CMA
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- 2 corroborating sources
- partial dose data
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Aliases: P-cma, Para-cma, Ro 4-6861
Summary
4-CMA is a prodrug that metabolizes to 4-Chloroamphetamine (4-CA), which selectively destroys serotonergic axon terminals. Lasting mood, cognitive and sleep disturbances have been reported after single exposures. Tablets seized in Europe contained 25-150 mg active drug.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | - | - | 60+ mg (not recommended) |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 2-4 hrs | 3.33-8 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate stimulation and sensory enhancement, mild empathy
Strong anxiety/jitters and euphoria with mild stimulation
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The PsychonautWiki Journal logging app doesn't include every substance. To track 4-CMA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4-CMA Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold ~5 (extrapolated) · light 5-15 · heavy 60+ (not recommended) Oral duration: onset 0.33-1h · peak 1-3h · offset 2-4h · total 3.33-8h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Physical euphoria
- Temperature regulation suppression
- Teeth grinding
- Increased heart rate
- Insomnia
- Pupil dilation
- Vasoconstriction
- Increased perspiration
- Neurotoxicity symptoms
- Cognitive euphoria
- Wakefulness
- Mood lift
- Empathy enhancement
- Increased sociability
- Anxiety
- Motivation suppression
- Thought deceleration
- Depression
- Cognitive fatigue
- Tactile enhancement
- Increased music appreciation
- Increased libido
- Tracers
- Color enhancement
- Pattern recognition enhancement
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
Combinations
Cross-Check 4-CMA with another substanceHelpful Links
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