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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-CMA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • partial dose data
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: P-cma, Para-cma, Ro 4-6861

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    4-CMA is a prodrug that metabolizes to 4-Chloroamphetamine (4-CA), which selectively destroys serotonergic axon terminals. Lasting mood, cognitive and sleep disturbances have been reported after single exposures. Tablets seized in Europe contained 25-150 mg active drug.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 5-15mg - - 60+mg(notrecommended)
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Oral 20-60 min 1-3 hrs 2-4 hrs 2-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 6.4
    Strong 6/10

    Strong euphoria with moderate stimulation and sensory enhancement, mild empathy

    Empathy / Social Openness ×3
    5
    empathy enhancement increased sociability
    Euphoria / Mood Elevation ×2
    8
    physical euphoria cognitive euphoria mood lift
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 3.9
    Moderate 4/10

    Strong anxiety/jitters and euphoria with mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    8
    physical euphoria cognitive euphoria mood lift
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-CMA
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Temperature regulation suppression
    • Teeth grinding
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Vasoconstriction
    • Increased perspiration
    Neutral
    • Neurotoxicity symptoms
    Positive
    • Cognitive euphoria
    • Wakefulness
    • Mood lift
    • Empathy enhancement
    • Increased sociability
    Negative
    • Anxiety
    • Motivation suppression
    • Thought deceleration
    • Depression
    • Cognitive fatigue
    Positive
    • Tactile enhancement
    • Increased music appreciation
    • Increased libido
    • Tracers
    • Color enhancement
    • Pattern recognition enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition

    Combinations TripSit

    Cross-Check 4-CMA with another substance

    4-CMA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki