4-CMA
Aliases: P-cma, Para-cma, Ro 4-6861
Summary
4-CMA is a prodrug that metabolizes to 4-Chloroamphetamine (4-CA), which selectively destroys serotonergic axon terminals. Lasting mood, cognitive and sleep disturbances have been reported after single exposures. Tablets seized in Europe contained 25-150 mg active drug.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | - | - | 60+mg(notrecommended)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 2-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Empathogen
6.4
Strong
6/10
Strong euphoria with moderate stimulation and sensory enhancement, mild empathy
Empathy / Social Openness
×3
5
empathy enhancement
increased sociability
Euphoria / Mood Elevation
×2
8
physical euphoria
cognitive euphoria
mood lift
Stimulation
×1
7
stimulation
wakefulness
teeth grinding
increased heart rate
Sensory Enhancement
×1
7
tactile enhancement
color enhancement
increased libido
Stimulant
3.9
Moderate
4/10
Strong anxiety/jitters and euphoria with mild stimulation
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
8
physical euphoria
cognitive euphoria
mood lift
Focus / Productivity
×2
0
Anxiety / Jitters
×1
10
anxiety
teeth grinding
increased heart rate
vasoconstriction
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Temperature regulation suppression
- Teeth grinding
- Increased heart rate
- Insomnia
- Pupil dilation
- Vasoconstriction
- Increased perspiration
- Neurotoxicity symptoms
Positive
- Cognitive euphoria
- Wakefulness
- Mood lift
- Empathy enhancement
- Increased sociability
Negative
- Anxiety
- Motivation suppression
- Thought deceleration
- Depression
- Cognitive fatigue
Positive
- Tactile enhancement
- Increased music appreciation
- Increased libido
- Tracers
- Color enhancement
- Pattern recognition enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
Combinations
4-CMA's nerd page
Pharmacology, chemical data, effect profiles, and more
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