4-Fluorodeprenyl Stats & Data

4‑Fluorodeprenyl is presumed to act as an irreversible, selective MAO‑B inhibitor at low doses by close analogy to selegiline; selectivity can diminish at higher doses, increasing tyramine sensitivity and hypertensive risk. Evidence from selegiline shows loss of strict MAO‑B selectivity with dose escalation and standard 14‑day washouts when switching to serotonergic agents; similar caution is prudent here. The functional duration of MAO‑B inhibition (24–48 h) outlasts the subjective stimulation, so redosing within this window can stack enzyme inhibition and unpredictably amplify interactions. Selegiline is metabolized via CYP2B6 (major) and CYP3A4/2A6 (minor) to active amphetamine/methamphetamine metabolites; 4‑fluorodeprenyl likely follows a similar CYP pattern, so strong inducers/inhibitors may alter exposure. By structure analogy to selegiline, para‑fluoro substitution implies possible formation of 4‑fluoromethamphetamine and 4‑fluoroamphetamine as metabolites; this is plausible but not directly confirmed in humans—treat as a risk that could add serotonergic/stimulant load. Avoid combining with serotonergic drugs (SSRIs/SNRIs/TCAs/MDMA/DXM/tramadol) or certain antibiotics (linezolid) and dyes (methylene blue) due to serotonin‑toxicity risk established for MAO inhibitors. At higher doses, counsel on tyramine control (aged cheeses, cured meats, soy products, certain beers/wines) because irreversible MAO inhibition can precipitate hypertensive crises, especially as MAO‑A inhibition emerges. Monitor for insomnia, anxiety, headache, orthostatic hypotension, and BP elevation; these are documented with selegiline and are possible here. If used more than once weekly, consider spacing doses by at least 48 h (preferably longer) to avoid accumulation of irreversible MAO‑B inhibition. Because RC markets are error‑prone, get samples analyzed by a trusted drug‑checking service; mislabeling and batch variability are common, and ‘lab screenshots’ from sellers can be misleading or outdated. If switching to or from serotonergic prescription meds, use conservative washouts (often 14 days for irreversible MAOIs) unless a clinician directs otherwise.