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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Fluorodeprenyl Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Fludepryl, Sr-96516-a, Chinoin-175, P-f-deprenyl, P-fluoro-l-deprenyl

    Stimulant Nootropic Research-chemical

    Summary dose.wiki

    Metabolizes to 4-fluoroamphetamine and 4-fluoromethamphetamine, which may add dopaminergic load and extend duration. Risk of serotonin syndrome when combined with serotonergic drugs. At higher doses (>10 mg) selectivity for MAO-B diminishes, increasing dietary tyramine risk and potential for non-selective MAO inhibition.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges are compiled primarily from scattered user reports and analog reasoning from selegiline; no controlled human dosing data for 4‑fluorodeprenyl exists. Start at the low end due to irreversible MAO‑B inhibition and interindividual CYP variability (notably CYP2B6/3A4 for selegiline; 4‑fluorodeprenyl is likely similar). Redosing within 24–48 h can stack functional MAO‑B inhibition. Sublingual use bypasses some first‑pass metabolism (by analogy to selegiline ODT), often increasing potency. User‑report‑derived only; titrate cautiously. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 1-2mg 2-5mg 5-10mg 10mg+
    Sublingual 0.5-1mg 1-3mg 3-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 1-2 hrs 2-4 hrs 4-8 hrs 24-48 hrs 7.5-15 hrs
    Sublingual 15-30 min 30-90 min 2-4 hrs 4-8 hrs 24-48 hrs 6.75-14 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.4
    Moderate+ 5/10

    Moderate focus and anxiety/jitters with mild stimulation and euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    6
    anxiety increased heart rate
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Fluorodeprenyl there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Fluorodeprenyl (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Fluorodeprenyl
    Unit
    mg
    Description 
    4-Fluorodeprenyl
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 0.5 · light 1-2 · common 2-5 · strong 5-10 · heavy 10+
Sublingual dose (mg): threshold 0.25 · light 0.5-1 · common 1-3 · strong 3-6 · heavy 6+

Oral duration: onset 0.5-1h · come-up 1-2h · peak 2-4h · offset 4-8h · total 7.5-15h · after-effects 24-48h
Sublingual duration: onset 15-30m · come-up 0.5-1.5h · peak 2-4h · offset 4-8h · total 6.75-14h · after-effects 24-48h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 3.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    Irreversible MAO‑B inhibition recovers via enzyme resynthesis over days to weeks, not by drug clearance; subjective stimulant tolerance appears limited, but functional interactions persist for 24–48 h post‑dose. Values are heuristic, based on MAOI pharmacology rather than direct human datasets for this analog.

    Cross-Tolerances

    Selegiline
    100%
    Rasagiline
    60%
    Amphetamines (subjective stimulant effects only)
    30%

    Effects dose.wiki

    Positive
    • Stimulation
    • Physical fatigue reduction
    • Reduced fatigue
    Negative
    • Insomnia
    • Increased heart rate
    • Slight appetite suppression
    • Occasional insomnia
    • Headaches
    • Nausea
    • Headache
    Positive
    • Euphoria
    • Focus enhancement
    • Motivation enhancement
    • Wakefulness
    • Sociability enhancement
    • Subtle mental alertness
    • Enhanced motivation
    • Mild euphoria
    Negative
    • Anxiety
    Neutral
    • Thought acceleration
    Positive
    • Increased libido
    • Libido enhancement
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Photophobia
    Neutral
    • Spontaneous physical sensations

    Combinations

    Cross-Check 4-Fluorodeprenyl with another substance

    4-Fluorodeprenyl's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki