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    4-Fluoropentedrone molecular structure

    4-Fluoropentedrone Stats & Data

    4-fpd 4-f-pentedrone 4-fluoro-alpha-methylamino-valerophenone 4f-pentedrone
    NPS DataHub
    MW209.26
    FormulaC12H16FNO
    IUPAC1-(4-fluorophenyl)-2-(methylamino)pentan-1-one
    SMILESCCCC(NC)C(=O)c1ccc(F)cc1
    InChIKeyQBFXBDUCRNGHSA-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Cathinone
    Psychoactive Class Stimulant
    Half-Life Estimated 2–4 h (extrapolated from pentedrone; no human PK study)

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine reuptake inhibitor
    Norepinephrine reuptake inhibitor

    Effect Profile

    Curated
    Stimulant 4.6

    Strong anxiety/jitters with moderate euphoria and focus, low stimulation

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Estimated 2–4 h (extrapolated from pentedrone; no human PK study)
    Addiction Potential
    Moderate-to-high. Like other dopamine/norepinephrine transporter inhibitors in the cathinone class, it likely promotes compulsive redosing and binge patterns; cathinones produce sympathomimetic toxicity and reinforcement similar to cocaine/amphetamines. Evidence: class neuropharmacology and clinical toxicology case series; user communities frequently report compulsive use with phenidates/cathinones.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~7d

    Anecdotal patterns suggest rapid tolerance with binge/redosing across 1–2 days, partial decay over 3–7 days, and near‑baseline by ~2 weeks. Data quality is low and varies widely among individuals.

    Cross-Tolerances

    Other cathinones
    60% ●○○
    Amphetamines
    40% ●○○
    Cocaine
    30% ●○○

    Harm Reduction

    drugs.wiki

    Reason for additions/edits: 1) Identity and naming cross-checked with PubChem; human PK for 4‑FPD is uncharacterised, so dose/ROA guidance emphasises allergy/test-dosing and milligram-accurate weighing. 2) Acute harm-reduction focuses on managing a sympathomimetic toxidrome: benzodiazepines are first-line in severe agitation/hyperthermia; avoid pure beta‑blockers as monotherapy during acute intoxication due to unopposed α-agonism risk; seek urgent care for chest pain, confusion, high fever, or persistent tachycardia. 3) Overheating and dehydration are common with cathinones: plan cool‑down breaks; sip ~250 ml water/hour at rest (up to ~500 ml/hour if active) plus electrolytes; avoid over‑hydration. 4) Insufflation: high risk of mucosal injury; crush finely, use personal sterile equipment, rinse with saline before/after, alternate nostrils, and avoid sharing to reduce BBV risks. 5) Rectal use: dissolve in sterile water, lubricate, shallow insertion; precise volumetric dosing reduces local irritation. 6) Drug checking: single reagents can be misleading; prefer multi‑reagent panels (Marquis, Froehde, Simon’s, Zimmermann, Morris) and, where available, FTIR/GC‑MS drug checking; be cautious of cathinones mis-sold as MDMA or mixed in stimulants. 7) Interactions: MAOIs are high‑risk; tramadol and bupropion lower seizure threshold; co‑use with serotonergics (e.g., SSRIs/SNRIs/MDMA) increases serotonin‑toxicity risk; combining with QT‑prolonging agents increases arrhythmia risk. 8) Driving/complex tasks: stimulants and residual effects impair sleep and reaction time; community guidance suggests waiting at least 48 h after cathinone use before driving. 9) We removed an earlier, specific reagent‑color and purity range claim due to insufficient reliable sourcing and replaced it with general multi‑reagent and lab‑testing guidance. Evidence sources are cited below.

    References

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