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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-HO-MET Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 5 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical

    Aliases: Metocin, Methylcybin, 4homet, homet

    Summary TheDrug.Wiki Erowid

    4-HO-MET is a synthetic tryptamine analogue of psilocin first synthesized by Alexander Shulgin. Often described as more recreational than psilocybin mushrooms due to its lighter headspace and more prominent visual effects with less cognitive intensity. Individual response varies significantly; some users report intense experiences at low doses while others report mild effects at higher doses, possibly due to variations in neurochemistry, metabolism, or batch quality.

    Perspectives

    “4-HO-MET felt kinda like mushrooms, but without the overwhelming-ness or the destruction of autonomy. Neutered mushroomsβ€”providing psychedelic effects while maintaining greater personal control.”

    “This was still a positive low-end experience, with no real negatives or unwanted side effects. I hope to return to this in due course.”

    Dose Information TheDrug.Wiki PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-25mg 25-45mg 45mg+
    Intravenous 5mg 10-15mg 20mg 20mg+
    Smoked 10-25mg 25-35mg 35-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-40 min 30-60 min 2-3 hrs 60-90 min 2-12 hrs 4-6 hrs
    Insufflated 5-25 min - - - 2-8 hrs 3-7 hrs
    Intravenous 2-10 min - - - 2-8 hrs 3-7 hrs
    Smoked 2 min - - - 2-8 hrs 25-45 min

    Effect Profile

    132 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 104 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.4
    Intense 8/10

    Strong visuals, auditory effects, body load, and headspace

    Visual Intensity ×3
    10
    color enhancement drifting synaesthesia pattern recognition enhancement colour shifting after images +1 more
    Headspace Depth ×3
    9
    conceptual thinking time distortion
    Auditory Effects ×1
    10
    synaesthesia
    Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression increased heart rate

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 7d Baseline ~14d

    Estimates reflect typical serotonergic psychedelic patterns; individual variability is high and data are anecdotal/community-derived. Redosing within the same day produces diminishing returns.

    Effects Erowid Bluelight

    Aggregated from 104 Erowid and 28 Bluelight experience reports

    Positive Effects 67

    Color Enhancement 60.6% 89%
    Music Enhancement 50.8% 86%
    Euphoria 47.0% 90%
    Joy 46.4% 86%
    Geometric Imagery 39.3% 90%
    Introspection 37.1% 82%
    Awe 35.7% 83%
    Closed-Eye Visuals 34.9% 91%
    Stimulation 33.4% 80%
    Surface Breathing 32.1% 87%
    Contentment 28.6% 82%
    Entity Imagery 28.6% 83%
    Focus Enhancement 27.3% 82%
    Sedation 27.3% 80%
    Tactile Enhancement 27.3% 85%
    Visual Trails 21.4% 82%
    Patterning 21.4% 92%
    Insight 21.4% 84%
    Ego Dissolution 19.7% 86%
    Open-Eye Visuals 18.2% 91%

    Adverse Effects 40

    Anxiety 59.9% 82%
    Body Load 42.9% 75%
    Confusion 34.1% 77%
    Nausea 30.3% 90%
    Fear 25.0% 88%
    Auditory Effects 25.0% 81%
    Panic 17.9% 86%
    Thought Disorganization 17.9% 81%
    Muscle Tension 17.3% 70%
    Depersonalization 14.3% 86%
    Thought Loops 13.6% 77%
    Dysphoria 10.7% 83%
    Sweating 10.6% 85%
    Headache 9.9% 75%
    Jaw Clenching 7.5% 82%
    Paranoid Ideation 7.1% 80%
    Frequent Urination 7.1% 78%
    Derealization 7.1% 85%
    Identity Confusion 7.1% 88%
    Motor Impairment 6.8% 78%

    Combinations TripSit

    Cross-Check 4-HO-MET with another substance

    Trip Reports Effect Index

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
    So Is That 4-HO-MET, Right? positive exp #89111

    Hello everyone, First of all sorry for my english, hope you can understand! After a long absence I'm back but I preferred to wait a while before coming back because I had a sacred experience .... I'll tell you. First I start with my first test which was the best of all my test.

    ErowidLover · 8 mg oral / 8 mg oral / smoked / smoked
    Wracked With Color positive exp #107733

    T0:00-Dose after a light meal (a small bag of chips and some wafers) T0:40-Not feeling anything other than some nausea T1:10-Drink a lot of water. This seem to break the capsule. Am suddenly hit with a burgeoning comeup, like a bubble inflating. Ho boy. No sensory effects yet, just nausea and lightheadedness.

    nervewing
    Discovering God as the Fully Evolved Being positive exp #97521

    Hello, all. I'm here to share with whatever audience a story of somewhat of a spiritual awakening of 3 people. This is a story of 17-year-old me experimenting with 4-hydroxylized tryptamines with two of my best friends, N and S.

    Pelipper · 20 mg insufflated / 8 mg oral / 8 mg oral / bowls smoked
    Surpise, Surprise neutral exp #115211

    This was my second time with this drug, and the first for my friend. We are both very experienced with a wide variety of classical and novel psychedelics, although we rarely push the doses to the high level and even more rarely take heavy doses.

    Pfaffffed · 10 - 11 mg oral / 10 - 11 mg oral / 3 tablets oral / oral
    Anchored in Eternity neutral exp #118903

    Setting: My bedroom in my hometown Much has happened since writing up this experience with 4 HO MET [two weeks ago], appearing to be one of many seeds to which my life has blossomed in unexpected directions, for some brief condensed conscious background: I started a new job which has brought about a growing help to mys...

    Mouthspiral · 17 mg oral
    Early Metocin Impressions neutral exp #104774

    This write-up will cover the last three experiences I've had with metocin since I last uploaded any trip reports. These three trips were all wonderful, but I didn't feel that they all really called for individual reports of their own.

    Goddess Mode
    My First Bad Trip - I Didn't Weight It Out cautionary exp #114777

    [Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts.

    DeStuert · insufflated
    New Favorite Drug cautionary exp #91175

    7:15PM: Took the dose dissolved in water with my boyfriend. I was really nervous because I had taken a dose of 2-CE recently and it had messed with my stomach to the point where I had a horrible trip and it made me never want to trip again. 7:35PM: I'm feeling really bad effects at this time.

    Kate · 17 mg oral / smoked
    Bluelight 2 threads 2 neutral visit
    Metocin First Time 32mg Frequent Tripper Psilocins Little Brother neutral

    After my last experience with smoked DMT, I was left with the feeling that I had been shown all that this particular material would be able to show me at this point in my life. Coming down from my last DMT flash, I felt a voice of guidance communicate to me to return to exploring the sacred mushroom and Ayahuasca.

    scraped 2026-03-14
    Metocin 39mg And Syrian Rue Smoked Frequent Tripper Vegetable Television neutral

    After my first experience with metocin I felt inclined to try to achieve β€œvegetable television” with this material. β€œVegetable television” is a term that was used most famously by Terence McKenna to describe the state of combining psilocybin/psilocin mushrooms with a dose of smoked Syrian rue (Peganum harmala) seeds.

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    Tryptamines The Big & Dandy 4-HO-MET Thread - Part 3 - 4-HO-ME's for life

    Welcome to the Big & Dandy 4-HO-MET Thread - Version 3 CAS# for freebase: 77872-41-4 Previous threads: Previous Big & Dandy Thread (Part 2) First Big & Dandy Thread Subthreads: Solubility & stability Health & safety External Links: Wikipedia Page on 4-HO-MET Erowid 4-HO-MET Vault Erowid Trip Reports Excerpt from TIHKAL...

    Read full thread on Bluelight β†’

    PiHKAL / TiHKAL Shulgin

    TiHKAL #21: 4-HO-MET

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