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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-HO-MET

    Aliases: Colour, Metocin, Methylcybin, 4homet, homet, ethocin

    Psychedelic Research-chemical

    Summary TheDrug.Wiki Erowid

    4-HO-MET is a synthetic tryptamine analogue of psilocin first synthesized by Alexander Shulgin. Often described as more recreational than psilocybin mushrooms due to its lighter headspace and more prominent visual effects with less cognitive intensity. Individual response varies significantly; some users report intense experiences at low doses while others report mild effects at higher doses, possibly due to variations in neurochemistry, metabolism, or batch quality.

    Perspectives

    “4-HO-MET felt kinda like mushrooms, but without the overwhelming-ness or the destruction of autonomy. Neutered mushrooms—providing psychedelic effects while maintaining greater personal control.”

    “This was still a positive low-end experience, with no real negatives or unwanted side effects. I hope to return to this in due course.”

    Dose Information TheDrug.Wiki PsychonautWiki TripSit

    ROA Light Common Strong Heavy
    Oral 10mg 10-15mg 20mg 20mg+
    Intravenous 5mg 10-15mg 20mg 20mg+
    Smoked 10-25mg 25-35mg 35-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 15-40 min 30-60 min 2-3 hrs 60-90 min 2-12 hrs 4-6 hrs
    Insufflated 0-1 min - - - 2-8 hrs 0-1 min
    Intravenous 1-10 min - 3-7 hrs - 2-8 hrs 3-7 hrs

    Effect Profile

    132 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 104 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 8.4
    Intense 8/10

    Strong visuals, auditory effects, body load, and headspace

    Visual Intensity ×3
    10
    color enhancement drifting synaesthesia pattern recognition enhancement colour shifting after images +1 more
    Headspace Depth ×3
    9
    conceptual thinking time distortion
    Auditory Effects ×1
    10
    synaesthesia
    ⚠ Body Load / Somatic Effects ×1
    10
    nausea temperature regulation suppression increased heart rate
    Based on reports from:
    Effect Index Wracked with Color Effect Index Unity with a Friend Effect Index My Fourth Experience with Unity Effect Index Cosmic Copyright Warning Effect Index Extreme Psychosis
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 4d Baseline ~14d

    Estimates reflect typical serotonergic psychedelic patterns; individual variability is high and data are anecdotal/community-derived. Redosing within the same day produces diminishing returns.

    Cross-Tolerances

    Psilocybin/Psilocin
    70%
    LSD and analogues
    60%
    Other 4-substituted tryptamines (e.g., 4-AcO-MET/4-HO-MiPT)
    70%

    Effects Erowid Bluelight

    Aggregated from 104 Erowid and 28 Bluelight experience reports

    Positive Effects 67

    Color Enhancement 60.6% 89%
    Music Enhancement 50.8% 86%
    Euphoria 47.0% 90%
    Joy 46.4% 86%
    Geometric Imagery 39.3% 90%
    Introspection 37.1% 82%
    Awe 35.7% 83%
    Closed-Eye Visuals 34.9% 91%
    Stimulation 33.4% 80%
    Surface Breathing 32.1% 87%
    Contentment 28.6% 82%
    Entity Imagery 28.6% 83%
    Focus Enhancement 27.3% 82%
    Sedation 27.3% 80%
    Tactile Enhancement 27.3% 85%
    Visual Trails 21.4% 82%
    Patterning 21.4% 92%
    Insight 21.4% 84%
    Ego Dissolution 19.7% 86%
    Open-Eye Visuals 18.2% 91%

    Adverse Effects 40

    Anxiety 59.9% 82%
    Body Load 42.9% 75%
    Confusion 34.1% 77%
    Nausea 30.3% 90%
    Fear 25.0% 88%
    Auditory Effects 25.0% 81%
    Panic 17.9% 86%
    Thought Disorganization 17.9% 81%
    Muscle Tension 17.3% 70%
    Depersonalization 14.3% 86%
    Thought Loops 13.6% 77%
    Dysphoria 10.7% 83%
    Sweating 10.6% 85%
    Headache 9.9% 75%
    Jaw Clenching 7.5% 82%
    Paranoid Ideation 7.1% 80%
    Frequent Urination 7.1% 78%
    Derealization 7.1% 85%
    Identity Confusion 7.1% 88%
    Motor Impairment 6.8% 78%

    Combinations TripSit

    Trip Reports Effect Index

    Wracked with Color nervewing Unity with a Friend Josie My Fourth Experience with Unity Josie Cosmic Copyright Warning Rho Extreme Psychosis Cocoanatta

    PiHKAL / TiHKAL Shulgin

    TiHKAL #21: 4-HO-MET
    4-HO-MET's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 Bluelight 📖 The Drug Users Bible