4-HO-PiPT - Substance Search

Summary dose.wiki

4-HO-PiPT is a novel substituted tryptamine first identified in 2021 in British Columbia, Canada. It is characterized by an unusually short duration (2-4 hours) compared to most psychedelics, with intense visuals and a heavy bodyload. Users report strong tactile enhancement, significant nausea, confusion, and disorientation during the peak.

Perspectives

“4-HO-PiPT was oddly intense in some respects, mild in others. The visual space was an explosion of forms and energy, great iridescent blue ripples with my eyes open and a world of vibrant metallic glowing forms, twisting and dancing with my eyes closed.”

— Nervewing, nervewing.blogspot.com 35 mg oral

Dose Information dose.wiki Drugs.Wiki

Dose basis. Dose ranges are aggregated from limited user reports and analog inference from closely related 4‑substituted tryptamines; high interindividual variability—start with an allergy test (0.5–1 mg) and titrate slowly. Accurately weigh with a milligram scale; for small increments consider volumetric dosing (TripSit Volumetric Converter). Salt form affects mass potency: like other 4‑sub tryptamines, fumarate vs HCl/freebase can differ by ~10–25% by weight; vendors may vary. Information is primarily anecdotal and should be treated as tentative. (Dose figures and this note are from Drugs.Wiki.)

ROA	Light	Common	Strong	Heavy
Oral	5-10mg	10-20mg	20-30mg	30mg+

Light Common Strong Heavy

Onset, Duration & After-effects dose.wiki Drugs.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	15-30 min	15-30 min	30-60 min	1-2 hrs	1-2 hrs	2-4 hrs

Effect Profile

5 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 4.0

Moderate 4/10

Strong body load with moderate visuals, mild headspace

Visual Intensity ×3

6

color enhancement drifting tracers

Headspace Depth ×3

4

introspection time distortion confusion

Auditory Effects ×1

0

⚠ Body Load / Somatic Effects ×1

8

nausea vasoconstriction muscle tension increased heart rate

Based on reports from:

Erowid Experience Reports

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track 4-HO-PiPT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "4-HO-PiPT (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

4-HO-PiPT

Unit

mg

Description

4-HO-PiPT
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2 · light 5-10 · common 10-20 · strong 20-30 · heavy 30+

Oral duration: onset 15-30m · come-up 15-30m · peak 0.5-1h · offset 1-2h · total 2-4h · after-effects 1-2h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 2d Half tolerance 7d Baseline ~10d

Acute tachyphylaxis typical of psychedelics develops within the session, with marked short‑term tolerance for ~24–48 h. By ~1–2 weeks, response approximates baseline. Cross‑tolerance across serotonergic psychedelics is expected. Data quality: anecdotal extrapolation from related 4‑HO compounds; conservative spacing (≥14 days) reduces risk of cumulative psychological strain.

Cross-Tolerances

Psilocin/psilocybin

70%

LSD/lysergamides

50%

Other 4‑substituted tryptamines (e.g., 4‑HO/4‑AcO‑MET, MiPT, DiPT)

60%

Effects Erowid

Aggregated from 5 Erowid experience reports

Positive Effects 7

Euphoria 100.0% 70%

Tactile Enhancement 100.0% 70%

Empathy 80.0% 70%

Stimulation 80.0% 70%

Introspection 60.0% 70%

Body High 60.0% 70%

Color Enhancement 60.0% 70%

Adverse Effects 2

Anxiety 60.0% 70%

Confusion 60.0% 70%

Combinations

Cross-Check 4-HO-PiPT with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 3 reports 1 positive 2 neutral visit

Alien Comfort neutral exp #115140

4-HO-PiPT - first trial - threshold I just tested my 4-HO-PiPT with Ehrlich and Froehde, because that's about all that I can think of. It tested as expected, so it's some kind of indole.

Pushing the Boundaries neutral exp #115770

Ive been experimenting with 4-HO-PiPT fumarate for about a year now. As it is a relatively new substance, I would like to provide the world some documentation with regards to this chemical. Ive always procured my supply from the same source.

Everything Seemed Faster positive exp #116684

Piprocin, A Novel Experience A few weeks ago I had tried 20mg piprocin (4-HO-PiPT) and made a post on it in r/obscuredrugs. It was a decent substance, good bodyload, a ton of tactile euphoria but mild visuals.

4-HO-PiPT's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki

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4-HO-PiPT Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 2 corroborating sources 1 ROA with full dose ladder duration data present 19 combo interactions documented classified Research-chemical dose data not in PW/TripSit (unverifiable)