Summary
4-MAR exists as cis- and trans-stereoisomers; recreational preparations typically contain racemic cis-4-MAR. Users report clear empathic stimulation with minimal peripheral side effects at moderate doses (10-20 mg), but pronounced vasoconstriction and compulsive redosing at higher doses. Vaporization produces intense rapid onset despite maintaining 6-8 hour duration. Historical case reports link chronic use to pulmonary hypertension. Harm reduction includes maintaining cool ambient temperature, frequent hydration, and magnesium supplementation to reduce bruxism.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-5mg | 5-10mg | 10-15mg | 40-100mg+ |
| Insufflated | 5-10mg | 10-30mg | 30-50mg | 50mg+ |
| Smoked / Vaporized | 5-10mg | 10-20mg | 30-60mg | 50mg+ |
| Intravenous | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
| Smoked | 5-10mg | 10-20mg | 30-60mg | 50mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 0.75-2 hrs | 1-2 hrs | 2-4 hrs | 4-10 hrs | 48 hrs |
| Insufflated | 20-40 min | 30-60 min | 1-3 hrs | 3-6 hrs | 48 hrs |
| Smoked / Vaporized | 0-1 min | 5-15 min | 1-3 hrs | 4-8 hrs | 48 hrs |
| Intravenous | - | - | - | - | 0 min |
| Smoked | - | - | - | - | 0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Stimulation
- Increased energy
Negative
- Teeth grinding
- Vasoconstriction
- Increased heart rate
- Insomnia
- Pupil dilation
- Increased blood pressure
- Increased perspiration
- Bruxism
Positive
- Euphoria
- Cognitive euphoria
- Motivation enhancement
- Focus enhancement
- Increased sociability
- Empathy enhancement
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Talkativeness
Positive
- Increased libido
- Increased music appreciation
- Visual enhancement
- Tactile enhancement
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Double vision
- Dulled perception