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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-MAR

    Aliases: Ice, U4ea, U4euh, 4-max, Euphoria

    Stimulant Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    4-MAR exists as cis- and trans-stereoisomers; recreational preparations typically contain racemic cis-4-MAR. Users report clear empathic stimulation with minimal peripheral side effects at moderate doses (10-20 mg), but pronounced vasoconstriction and compulsive redosing at higher doses. Vaporization produces intense rapid onset despite maintaining 6-8 hour duration.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 1-5mg 5-10mg 10-15mg 40-100mg+
    Insufflated 5-10mg 10-30mg 30-50mg 50mg+
    Smoked / Vaporized 5-10mg 10-20mg 30-60mg 50mg+
    Intravenous 5-10mg 10-20mg 20-40mg 40mg+
    Smoked 5-10mg 10-20mg 30-60mg 50mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 0.75-2 hrs 1-2 hrs 2-4 hrs 4-10 hrs 48-48 hrs
    Insufflated 20-40 min 30-60 min 1-3 hrs 3-6 hrs 48-48 hrs
    Smoked / Vaporized 0-1 min 5-15 min 1-3 hrs 4-8 hrs 48-48 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Strong anxiety/jitters with moderate stimulation and euphoria, mild focus

    Stimulation / Energy ×3
    7
    stimulation increased energy wakefulness
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate bruxism vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-MAR
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Increased energy
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Increased blood pressure
    • Increased perspiration
    • Bruxism
    Positive
    • Euphoria
    • Cognitive euphoria
    • Motivation enhancement
    • Focus enhancement
    • Increased sociability
    • Empathy enhancement
    • Wakefulness
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Talkativeness
    Positive
    • Increased libido
    • Increased music appreciation
    • Visual enhancement
    • Tactile enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    4-MAR's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki