4-Me-NEB
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Bz-6379, 4-methyl neb
Summary
4-Me-NEB (Bz-6379) is a cathinone stimulant sold as a research chemical, and has been detected in Japanese forensic surveys of "dangerous drug" herbal blends. Very limited human pharmacology data exists. User reports are highly variable: some batches appear largely inert below 100mg, while others enable prolonged wakefulness (48+ hours) with minimal euphoria but strong goal-directed focus, suggesting functional/ADHD-medication-like properties.
Dose Information
Dose basis. EXTRAPOLATED. Ranges inferred from closely related ethylcathinone-class stimulants (e.g., ethylcathinone; NEB/NEP reports) and typical cathinone potency. Always use a 0.001 g scale. Start at the low end due to batch variability and uncertain human potency. Insufflation is more caustic and carries higher compulsion; oral is generally lower-harm for cathinones. Evidence: Erowid ethylcathinone dose ranges; mephedrone health reports of nasal irritation/burning. EXTRAPOLATED. Many cathinones cause significant local irritation; small bumps and long spacing reduce tissue damage. Compulsion and rapid redosing risk are higher via this route. Consider liquid nasal rinses post-session. Evidence: Erowid mephedrone health notes and DrugWise cathinone risks highlighting nasal damage and compulsive redosing. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-80mg | 80-140mg | 140-220mg | 220mg+ |
| Insufflated | 5-20mg | 20-50mg | 50-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 1-2.5 hrs | 2-3 hrs | 3.25-6.25 hrs |
| Insufflated | 3-10 min | 1-2.5 hrs | 2-3 hrs | 3.05-5.67 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and anxiety/jitters with moderate stimulation, mild focus
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Me-NEB there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4-Me-NEB Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 20-40 · light 40-80 · common 80-140 · strong 140-220 · heavy 220+ Insufflated dose (mg): threshold 5 · light 5-20 · common 20-50 · strong 50-80 · heavy 80+ Oral duration: onset 15-45m · peak 1-2.5h · offset 2-3h · total 3.25-6.25h · after-effects 6-24h Insufflated duration: onset 3-10m · peak 1-2.5h · offset 2-3h · total 3.05-5.67h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 110 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal/theoretical: cathinones commonly show rapid within-session tolerance and partial cross‑tolerance across the class, with decay over 1–3 weeks. Avoid multi‑day use. Data quality low; based on mephedrone/NEP user reports and general stimulant patterns.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Increased heart rate
- Vasoconstriction
- Teeth grinding
- Dry mouth
- Insomnia
- Nausea
- Respiratory depression
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Alertness enhancement
- Cognitive euphoria
- Euphoria
- Anxiety suppression
- Anxiety
- Compulsive redosing
- Talkativeness
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Double vision
- Dulled perception
Combinations
Cross-Check 4-Me-NEB with another substanceHelpful Links
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