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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Me-NEB Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Bz-6379, 4-methyl neb

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    4-Me-NEB (Bz-6379) is a cathinone stimulant sold as a research chemical, and has been detected in Japanese forensic surveys of "dangerous drug" herbal blends. Very limited human pharmacology data exists. User reports are highly variable: some batches appear largely inert below 100mg, while others enable prolonged wakefulness (48+ hours) with minimal euphoria but strong goal-directed focus, suggesting functional/ADHD-medication-like properties.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 40-80mg 80-140mg 140-220mg 220mg+
    Insufflated 5-20mg 20-50mg 50-80mg 80mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-45 min 1-2.5 hrs 2-3 hrs 6-24 hrs 4-8 hrs
    Insufflated 3-10 min 1-2.5 hrs 2-3 hrs 6-24 hrs 4-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.0
    Strong 6/10

    Strong euphoria and anxiety/jitters with moderate stimulation, mild focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-Me-NEB
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 2d Half tolerance 3d Baseline ~28d

    Anecdotal/theoretical: cathinones commonly show rapid within-session tolerance and partial cross‑tolerance across the class, with decay over 1–3 weeks. Avoid multi‑day use. Data quality low; based on mephedrone/NEP user reports and general stimulant patterns.

    Cross-Tolerances

    Other cathinones
    60%
    Amphetamine derivatives
    40%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Increased heart rate
    • Vasoconstriction
    • Teeth grinding
    • Dry mouth
    • Insomnia
    • Nausea
    • Respiratory depression
    Neutral
    • Sedation
    Positive
    • Wakefulness
    • Focus enhancement
    • Motivation enhancement
    • Alertness enhancement
    • Cognitive euphoria
    • Euphoria
    • Anxiety suppression
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Talkativeness
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check 4-Me-NEB with another substance

    4-Me-NEB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki