Summary
4-MeO-MiPT (4-methoxy-N-methyl-N-isopropyltryptamine) is a rare synthetic psychedelic first reported by Alexander Shulgin (TiHKAL #39). User reports describe a relatively gentle, tactile, and mood-enhancing experience with mild visual effects and a shorter duration than related tryptamines. Recent pharmacological research reveals 4-MeO-MiPT exhibits potent serotonin reuptake inhibition (SSRI activity, IC50 = 57 nM) alongside 5-HT2A and 5-HT1A receptor agonism, which may account for its atypical psychedelic profile characterized by reduced classical psychedelic effects compared to 4-HO-MiPT and 4-AcO-MiPT. Body load is usually mild (slight jaw tension, pupil dilation, occasional nausea). Potency appears 1.5-2x weaker than 5-MeO-MiPT but batches on the grey market vary; test a low allergy dose (<1 mg).
Perspectives
“This substance isn't particularly exciting or interesting, just a novelty. I had low expectations for it and they were barely even met.”
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10mg | 10-20mg | 20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-2 hrs | 1-2 hrs | 1-3 hrs | 180-0 min |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 1-2 hrs | 1-3 hrs | 180-0 min |
Tolerance
Effects
- Body high
- Mild stimulation
- Mental/physical stimulation
- Restlessness
- Jaw tension
- Bruxism
- Sweating
- Pupil dilation
- Insomnia
- Sweating/chills
- Muscle tension
- Decreased appetite
- Mood lift
- Euphoria
- Enhanced sociability
- Empathy
- Insight
- Anxiety
- Confusion
- Increased talkativeness
- Time dilation
- Change in perception
- Ego softening
- Tactile enhancement
- Tracers
- Color saturation
- Auditory enhancement
- Brightened colour
- Enhanced tactile sensation
- Visual patterning
- Closed/Open eye visuals
- Drifting
- Auditory distortion
Combinations
Trip Reports
PiHKAL / TiHKAL
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”