4-MeO-MiPT - Substance Search

Summary TheDrug.Wiki TripSit

4-MeO-MiPT (4-methoxy-N-methyl-N-isopropyltryptamine) is a rare synthetic psychedelic first reported by Alexander Shulgin (TiHKAL #39). User reports describe a relatively gentle, tactile, and mood-enhancing experience with mild visual effects and a shorter duration than related tryptamines. Recent pharmacological research reveals 4-MeO-MiPT exhibits potent serotonin reuptake inhibition (SSRI activity, IC50 = 57 nM) alongside 5-HT2A and 5-HT1A receptor agonism, which may account for its atypical psychedelic profile characterized by reduced classical psychedelic effects compared to 4-HO-MiPT and 4-AcO-MiPT.

Perspectives

“This substance isn't particularly exciting or interesting, just a novelty. I had low expectations for it and they were barely even met.”

— Nervewing, nervewing.blogspot.com 40 mg oral

“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”

— Alexander Shulgin, TiHKAL (with 10 mg, orally)

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	10mg	10-20mg	20mg	20mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	15-45 min	30-60 min	1-2 hrs	1-2 hrs	1-3 hrs	2.8-5.8 hrs
Insufflated	5-15 min	15-30 min	1-2 hrs	1-2 hrs	1-3 hrs	2.3-4.8 hrs

Effect Profile

7 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 3.8

Moderate 4/10

Strong auditory effects with moderate body load, mild visuals, low headspace

Visual Intensity ×3

5

tracers drifting brightened colour

Headspace Depth ×3

1

confusion

Auditory Effects ×1

8

auditory enhancement auditory distortion

⚠ Body Load / Somatic Effects ×1

6

muscle tension bruxism jaw tension sweating

Based on reports from:

Effect Index Vestiges of a Trip TiHKAL TiHKAL #39: 4-MeO-MIPT Erowid Experience Reports PsychonautWiki 4-MeO-MiPT

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1d Half tolerance 3d Baseline ~10d

Rapid tolerance like other 5‑HT2A psychedelics; spacing sessions by 10–14 days helps restore baseline sensitivity. Evidence level: anecdotal/user‑report across tryptamines; no pharmacokinetic studies for 4‑MeO‑MiPT.

Cross-Tolerances

Other serotonergic psychedelics (e.g., LSD, psilocybin, 4‑HO/4‑AcO tryptamines)

60%

Effects Erowid

Aggregated from 7 Erowid experience reports

Positive Effects 7

Empathy 85.7% 70%

Color Enhancement 85.7% 70%

Music Enhancement 71.4% 70%

Euphoria 57.1% 70%

Focus Enhancement 57.1% 70%

Stimulation 42.9% 70%

Body High 42.9% 70%

Adverse Effects 2

Anxiety 42.9% 70%

Muscle Tension 42.9% 70%

Combinations TripSit

Trip Reports Effect Index

Vestiges of a Trip nervewing

PiHKAL / TiHKAL Shulgin

TiHKAL #39: 4-MeO-MIPT

“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”

— Alexander Shulgin, TiHKAL (with 10 mg, orally)

4-MeO-MiPT's nerd page Pharmacology, chemical data, effect profiles, and more

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