4-MeO-MiPT 25mg First Trial 2-10-2019 by Xorkoth I recently received a gift of samples of several tryptamines I did not previous have, from a friend who in turn was gifted some other rarities by me. One of them was 4-MeO-MiPT, an unusual substance I had been curious to try for some time.
4-MeO-MiPT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Summary
4-MeO-MiPT (4-methoxy-N-methyl-N-isopropyltryptamine) is a rare synthetic psychedelic first reported by Alexander Shulgin (TiHKAL #39). User reports describe a relatively gentle, tactile, and mood-enhancing experience with mild visual effects and a shorter duration than related tryptamines. Recent pharmacological research reveals 4-MeO-MiPT exhibits potent serotonin reuptake inhibition (SSRI activity, IC50 = 57 nM) alongside 5-HT2A and 5-HT1A receptor agonism, which may account for its atypical psychedelic profile characterized by reduced classical psychedelic effects compared to 4-HO-MiPT and 4-AcO-MiPT.
Perspectives
“This substance isn't particularly exciting or interesting, just a novelty. I had low expectations for it and they were barely even met.”
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10mg | 10-20mg | 20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-2 hrs | 1-2 hrs | 3-7 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2 hrs | 1-2 hrs | 3-7 hrs |
Effect Profile
7 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.8
Moderate
4/10
Strong auditory effects with moderate body load, mild visuals, low headspace
Visual Intensity
×3
5
tracers
drifting
brightened colour
Headspace Depth
×3
1
confusion
Auditory Effects
×1
8
auditory enhancement
auditory distortion
Body Load / Somatic Effects
×1
6
muscle tension
bruxism
jaw tension
sweating
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~10d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rapid tolerance like other 5‑HT2A psychedelics; spacing sessions by 10–14 days helps restore baseline sensitivity. Evidence level: anecdotal/user‑report across tryptamines; no pharmacokinetic studies for 4‑MeO‑MiPT.
Cross-Tolerances
Effects
Aggregated from 7 Erowid experience reports
Positive Effects 7
Empathy
85.7%
70%
Color Enhancement
85.7%
70%
Music Enhancement
71.4%
70%
Euphoria
57.1%
70%
Focus Enhancement
57.1%
70%
Stimulation
42.9%
70%
Body High
42.9%
70%
Adverse Effects 2
Anxiety
42.9%
70%
Muscle Tension
42.9%
70%
Combinations
Cross-Check 4-MeO-MiPT with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 6 neutral 1 cautionary visit
(4-MeO-MiPT / ~20mg) - First Time - 'Nice, But Not A Psychedelic' [This is not 4-HO-MiPT or 5-MeO-MiPT, two much more common tryptamines] Background: Experienced with dozens of tryptamine, phenethylamine, and lysergamide psychedelics, as well as quite a few arylcyclohexylamine and other dissociatives, RC stimulants, an...
To make it quick before you have to read the following novella on my lovely afternoon trip, I just wanted to say 2 things: 1. This is my first experience with an illegal drug, even a psychedelic. 2. I am writing this report as the clock ticks, meaning, I'm writing each entry at the time specified.
==Previous tolerance Took a microdose of 8mcg ALD-52 on the previous day, and 5mcg two days prior to that. I don't feel that this affected my tolerance. ==Mindset going into the experience In good spirits, things going well in my personal and professional lives.
Compounds I take daily: Piracetam - 1200 mg Phenibut - 750 mg Vinpocetine - 10 mg Noopept(another racetam) - 15 mg Time from the last recreational substance usage: 1 day, it was 20 mg of 4-AcO-DMT - I didn't like it, but it is the whole different story.
T0:00- 40 mg dissolved in solution because I had eaten a large meal earlier and because I wanted it to come on faster, as it was later into the night. T0:15- The first notes are subtle- lightheadedness, nausea, and feeling warm and sweaty.
Substance: 50mg 4-MEO-MIPT Expierence: First time Setting: At home, alone Gender: Male Age: 19 The trace effects of diazepam powder remain through my perception for the day and may effect the experience slightly.
PiHKAL / TiHKAL
TiHKAL #39: 4-MeO-MIPT
“In 30–40 minutes, I found I could get some distortions of objects around me, if I really tried hard. There are no color changes. It is unexpectedly mild, and I have no anxiety, no tachycardia. At the two hour point, the peak must be past, and I feel somehow disappointed. I am not sure, in retrospect, if there was ever anything there at all.”
4-MeO-MiPT's nerd page
Pharmacology, chemical data, effect profiles, and more
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