4-MeO-PCP Stats & Data
COc1ccc(cc1)C1(CCCCC1)N1CCCCC1MUZGGFNYVLGUFS-UHFFFAOYSA-NReceptor Profile
Receptor Actions
Receptor Binding
History & Culture
4-MeO-PCP was originally synthesized in 1965 by Victor Maddox, a medicinal chemist working at the pharmaceutical company Parke-Davis. The compound remained largely obscure for decades following its initial creation. Interest in 4-MeO-PCP resurfaced in the late 1990s when a chemist writing under the pseudonym John Q. Beagle published a 1999 review suggesting that the substance possessed reduced potency compared to its parent compound PCP. In 2001, Beagle followed this with a more comprehensive publication detailing the synthesis procedure and describing the qualitative effects, estimating its potency at approximately 70% that of PCP. The compound holds a notable place in the history of online research chemical markets as the first arylcyclohexylamine to be sold through internet vendors. It was introduced to the market in late 2008 by a supplier operating under the name CBAY. This marked the beginning of a wave of related dissociative compounds entering the research chemical scene, with 3-MeO-PCP and methoxetamine (MXE) following shortly thereafter.
Effect Profile
Curated + 7 ReportsStrong auditory effects with moderate visuals, mild headspace, low body load
Strong dissociative depth, mania, motor impairment, and insight
Duration Timeline
BluelightCommunity Effects
TripSitTolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 7 experience reports (7 Erowid)
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 2
Adverse Effects 1
Real-World Dose Distribution
62K DosesFrom 13 individual dose entries
Oral (n=10)
Form / Preparation
Most common forms and preparations reported
Legal Status
| Country | Status | Notes |
|---|---|---|
| Chile | Illegal | Prohibited under Ley 20000 (the Chilean drug control law), which explicitly covers all esters and ethers of phencyclidine. As 4-MeO-PCP is an ether of PCP, it falls under this provision. |
| Germany | Controlled (NpSG) | Controlled substance under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since September 27, 2021. Production, distribution, and possession with intent to supply are prohibited. |
| Sweden | Proposed hazardous substance | Sweden's public health agency recommended classifying 4-MeO-PCP as a hazardous substance on November 10, 2014. |
| Switzerland | Controlled (Verzeichnis E) | Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation. |
| Turkey | Illegal | Classified as a controlled drug under national legislation. Possession, production, supply, and importation are prohibited. |
| United Kingdom | Class B | Controlled under the Misuse of Drugs Act 1971. Covered by the arylcyclohexylamine generic clause added by S.I. 2013/239, which came into effect on February 26, 2013. This clause encompasses derivatives of 1-phenylcyclohexylamine where the amine has been replaced with a piperidyl group and further substituted in the phenyl ring with an alkoxy substituent. Possession, production, supply, and importation are prohibited. |
| United States | Unscheduled (Federal Analogue Act may apply) | Not federally scheduled, but may be prosecuted as a PCP analogue under the Federal Analogue Act when sold for human consumption or possessed with intent to ingest. The DEA has indicated it considers structurally similar recreational drugs to be controlled substance analogues. Virginia temporarily classified it as Schedule I from June 26, 2019 through December 25, 2020. |
References
Cited References
- Bluelight: The Big & Dandy 4-MeO-PCP Thread
- Drugs-Forum: 4-MeO-PCP (Methoxydine) Drug Info
- Erowid: 4-MeO-PCP Vault
- Isomer Design: 4-MeO-PCP
- Morris H, Wallach J. From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs
- Roth BL et al. The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor