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    4-MeO-PCP molecular structure

    4-MeO-PCP Stats & Data

    Methoxydine 4-methoxy-pcp 4meopcp
    NPS DataHub
    MW273.42
    FormulaC18H27NO
    CAS2201-35-6
    IUPAC1-[1-(4-methoxyphenyl)cyclohexyl]piperidine
    SMILESCOc1ccc(cc1)C1(CCCCC1)N1CCCCC1
    InChIKeyMUZGGFNYVLGUFS-UHFFFAOYSA-N
    Arylcyclohexylamines; 2021/6. Von Arylcyclohexylamin abgeleitete Verbindungen; 2022/6. Von Arylcyclohexylamin abgeleitete Verbindungen
    Psychoactive Class Dissociative / Psychedelic

    Receptor Profile

    Receptor Actions

    Antagonists
    NMDA receptor antagonist (selective ligand without appreciable dopamine transporter affinity)
    Other
    Sigma-1 receptor ligand
    Sigma-2 receptor ligand

    Receptor Binding

    NMDA antagonist

    History & Culture

    4-MeO-PCP was originally synthesized in 1965 by Victor Maddox, a medicinal chemist working at the pharmaceutical company Parke-Davis. The compound remained largely obscure for decades following its initial creation. Interest in 4-MeO-PCP resurfaced in the late 1990s when a chemist writing under the pseudonym John Q. Beagle published a 1999 review suggesting that the substance possessed reduced potency compared to its parent compound PCP. In 2001, Beagle followed this with a more comprehensive publication detailing the synthesis procedure and describing the qualitative effects, estimating its potency at approximately 70% that of PCP. The compound holds a notable place in the history of online research chemical markets as the first arylcyclohexylamine to be sold through internet vendors. It was introduced to the market in late 2008 by a supplier operating under the name CBAY. This marked the beginning of a wave of related dissociative compounds entering the research chemical scene, with 3-MeO-PCP and methoxetamine (MXE) following shortly thereafter.

    Effect Profile

    Curated + 7 Reports
    Psychedelic 6.5

    Strong auditory effects with moderate visuals, mild headspace, low body load

    Visual Intensity×3
    7
    Headspace Depth×3
    5
    Auditory Effects×1
    8
    Body Load / Somatic Effects×1
    2
    Dissociative 6.6

    Strong dissociative depth, mania, motor impairment, and insight

    Dissociative Depth×3
    10
    Mania / Compulsion×1
    10
    Insight / Novel Thought×2
    8
    Motor / Sensory Impairment×1
    10

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    45 minutes - 2.0 hours
    30 minutes - 1.5 hours
    3-7 hours
    6-10 hours
    6 hours
    Total: 12-20 hours
    Insufflated
    4-15 minutes
    15-30 minutes
    3-6 hours
    3 hours
    3 hours
    Total: 12-18 hours

    Community Effects

    TripSit
    Negative
    paranoia

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~28d

    Experience Report Analysis

    Erowid
    7 Reports
    2008–2013 Date Range
    6 With Age Data
    6 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 7 experience reports (7 Erowid)

    7 Reports
    6 Effects Detected
    2 Positive
    1 Adverse
    3 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 2

    Euphoria 57.1% 70%
    Focus Enhancement 42.9% 70%

    Adverse Effects 1

    Confusion 71.4% 70%

    Real-World Dose Distribution

    62K Doses

    From 13 individual dose entries

    Oral (n=10)

    Median: 112.5mg 25th: 80.0mg 75th: 168.75mg 90th: 302.5mg
    mg/kg median: 1.871 mg/kg 75th: 2.596

    Form / Preparation

    Most common forms and preparations reported

    Legal Status

    Country Status Notes
    Chile Illegal Prohibited under Ley 20000 (the Chilean drug control law), which explicitly covers all esters and ethers of phencyclidine. As 4-MeO-PCP is an ether of PCP, it falls under this provision.
    Germany Controlled (NpSG) Controlled substance under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since September 27, 2021. Production, distribution, and possession with intent to supply are prohibited.
    Sweden Proposed hazardous substance Sweden's public health agency recommended classifying 4-MeO-PCP as a hazardous substance on November 10, 2014.
    Switzerland Controlled (Verzeichnis E) Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation.
    Turkey Illegal Classified as a controlled drug under national legislation. Possession, production, supply, and importation are prohibited.
    United Kingdom Class B Controlled under the Misuse of Drugs Act 1971. Covered by the arylcyclohexylamine generic clause added by S.I. 2013/239, which came into effect on February 26, 2013. This clause encompasses derivatives of 1-phenylcyclohexylamine where the amine has been replaced with a piperidyl group and further substituted in the phenyl ring with an alkoxy substituent. Possession, production, supply, and importation are prohibited.
    United States Unscheduled (Federal Analogue Act may apply) Not federally scheduled, but may be prosecuted as a PCP analogue under the Federal Analogue Act when sold for human consumption or possessed with intent to ingest. The DEA has indicated it considers structurally similar recreational drugs to be controlled substance analogues. Virginia temporarily classified it as Schedule I from June 26, 2019 through December 25, 2020.
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