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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Methylephedrine Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4-me, 4-mmc metabolite, Dihydromephedrone, P-methylephedrine

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is limited.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Oral 20-40 min 1-2 hrs 1-3 hrs 1-4 hrs
    Insufflated 5-10 min 1-2 hrs 1-3 hrs 1-4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.0
    Moderate+ 5/10

    Strong stimulation and anxiety/jitters with moderate euphoria

    Stimulation / Energy ×3
    9
    increased energy stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    6
    euphoria cognitive euphoria
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    9
    anxiety tachycardia vasoconstriction sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-Methylephedrine
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Peripheral stimulation
    • Increased energy
    • Stimulation
    Negative
    • Sweating
    • Jaw tension / bruxism
    • Insomnia
    • Urinary retention
    • Vasoconstriction
    • Tachycardia
    • Increased blood pressure
    Positive
    • Mild euphoria
    • Increased sociability
    • Alertness enhancement
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Talkativeness
    • Time distortion
    Positive
    • Tactile enhancement
    • Increased music appreciation
    • Color enhancement
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    Cross-Check 4-Methylephedrine with another substance

    4-Methylephedrine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki