4-Methylephedrine
Aliases: 4-me, 4-mmc metabolite, Dihydromephedrone, P-methylephedrine
Categories
Summary
4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is limited. Available in-vitro data show it acts as a norepinephrine > dopamine transporter inhibitor/releaser with little serotonergic action, explaining its 'clean' peripheral stimulation and modest euphoria. CRITICAL WARNING: Reports suggest 4-ME may be significantly more cardiotoxic than ephedrine, with pronounced cardiovascular stress (tachycardia, vasoconstriction, blood-pressure rise) being more pronounced than central euphoria.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 20-40 min | 1-2 hrs | 1-3 hrs | 1-4 hrs |
| Insufflated | 5-10 min | 1-2 hrs | 1-3 hrs | 1-4 hrs |
Tolerance
Effects
- Peripheral stimulation
- Increased energy
- Stimulation
- Sweating
- Jaw tension / bruxism
- Insomnia
- Urinary retention
- Vasoconstriction
- Tachycardia
- Increased blood pressure
- Mild euphoria
- Increased sociability
- Alertness enhancement
- Euphoria
- Cognitive euphoria
- Wakefulness
- Anxiety
- Compulsive redosing
- Talkativeness
- Time distortion
- Tactile enhancement
- Increased music appreciation
- Color enhancement
- Increased libido
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Dulled perception
- Drifting