4-Methylephedrine
Aliases: 4-me, 4-mmc metabolite, Dihydromephedrone, P-methylephedrine
Summary
4-Methylephedrine (4-ME) is a phase-I reduction metabolite of the popular cathinone mephedrone (4-MMC). In users who take raw or poorly washed 4-MMC, small amounts may already be present as an impurity. Pure 4-ME occasionally appears on the grey market but formal pharmacology is limited.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 20-40 min | 1-2 hrs | 1-3 hrs |
| Insufflated | 5-10 min | 1-2 hrs | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.0
Moderate+
5/10
Strong stimulation and anxiety/jitters with moderate euphoria
Stimulation / Energy
×3
9
increased energy
stimulation
wakefulness
alertness enhancement
Euphoria / Mood Lift
×2
6
euphoria
cognitive euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
9
anxiety
tachycardia
vasoconstriction
sweating
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Effects
Positive
- Peripheral stimulation
- Increased energy
- Stimulation
Negative
- Sweating
- Jaw tension / bruxism
- Insomnia
- Urinary retention
- Vasoconstriction
- Tachycardia
- Increased blood pressure
Positive
- Mild euphoria
- Increased sociability
- Alertness enhancement
- Euphoria
- Cognitive euphoria
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Talkativeness
- Time distortion
Positive
- Tactile enhancement
- Increased music appreciation
- Color enhancement
- Increased libido
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Dulled perception
- Drifting
Combinations
4-Methylephedrine's nerd page
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