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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-MPM Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Aliases: Pal-747, Bontril, Adipost, Appecon, Melfiat, 4-methylphenmetrazine, mephenmetrazine

    Stimulant Empathogen Research-chemical

    Summary dose.wiki TripSit

    Phendimetrazine is a phenmetrazine prodrug prescribed for short-term obesity management. It metabolizes into active phenmetrazine, which has known abuse potential but with slower onset than direct administration. Tolerance develops rapidly with regular use.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-25mg 25-40mg 40mg+
    Insufflated 5-10mg 10-20mg 20-25mg 25mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 30-60 min 1-2 hrs 2-3 hrs 1-2 hrs 3.83-6.67 hrs
    Insufflated 5-15 min 15-30 min 1-2 hrs 2-3 hrs 1-2 hrs 3.33-5.75 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 5.4
    Moderate+ 5/10

    Strong stimulation with moderate euphoria, mild empathy, low sensory enhancement

    Empathy / Social Openness ×3
    5
    empathy increased sociability
    Euphoria / Mood Elevation ×2
    6
    euphoria cognitive euphoria
    Stimulation ×1
    10
    stimulation increased energy wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    1
    increased libido
    Stimulant 6.1
    Strong 6/10

    Strong anxiety/jitters with moderate stimulation, euphoria, and focus

    Stimulation / Energy ×3
    7
    stimulation increased energy wakefulness
    Euphoria / Mood Lift ×2
    7
    euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding tachycardia vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-MPM there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-MPM (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-MPM
    Unit
    mg
    Description 
    4-MPM
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 5-15 · common 15-25 · strong 25-40 · heavy 40+
Insufflated dose (mg): light 5-10 · common 10-20 · strong 20-25 · heavy 25+

Oral duration: onset 20-40m · come-up 0.5-1h · peak 1-2h · offset 2-3h · total 3.83-6.67h · after-effects 1-2h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1-2h · offset 2-3h · total 3.33-5.75h · after-effects 1-2h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 5d Half tolerance 3d Baseline ~21d

    Values are heuristic, synthesized from community reports and general stimulant tolerance patterns. Frequent consecutive‑day use produces noticeable acute tolerance; allowing 2+ weeks substantially reduces it.

    Cross-Tolerances

    3‑FPM (3‑fluorophenmetrazine) and related phenylmorpholine stimulants
    30%
    amphetamine‑type stimulants (class‑effect partial cross‑tolerance)
    20%

    Effects dose.wiki

    Positive
    • Stimulation
    • Increased energy
    • Increased energy/alertness
    Negative
    • Increased perspiration
    • Increased heart rate
    • Vasoconstriction
    • Teeth grinding
    • Insomnia
    • Pupil dilation
    • Tachycardia
    Positive
    • Euphoria
    • Increased sociability
    • Empathy
    • Focus enhancement
    • Motivation enhancement
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Compulsive redosing
    • Anxiety
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Increased libido
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Tinnitus
    • Dehydration
    • Light sensitivity
    • Disinhibition
    • Decreased libido
    Neutral
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness

    Combinations

    Cross-Check 4-MPM with another substance

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    4-MPM's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki