4-MPM - Substance Search

Summary TheDrug.Wiki TripSit

Phendimetrazine is a phenmetrazine prodrug prescribed for short-term obesity management. It metabolizes into active phenmetrazine, which has known abuse potential but with slower onset than direct administration. Tolerance develops rapidly with regular use.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	5-15mg	15-25mg	25-40mg	40mg+
Insufflated	5-10mg	10-20mg	20-25mg	25mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral	20-40 min	30-60 min	1-2 hrs	2-3 hrs	1-2 hrs
Insufflated	5-15 min	15-30 min	1-2 hrs	2-3 hrs	1-2 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Empathogen 5.4

Moderate+ 5/10

Strong stimulation with moderate euphoria, mild empathy, low sensory enhancement

Empathy / Social Openness ×3

5

empathy increased sociability

Euphoria / Mood Elevation ×2

6

euphoria cognitive euphoria

Stimulation ×1

10

stimulation increased energy wakefulness teeth grinding increased heart rate

Sensory Enhancement ×1

1

increased libido

Stimulant 6.1

Strong 6/10

Strong anxiety/jitters with moderate stimulation, euphoria, and focus

Stimulation / Energy ×3

7

stimulation increased energy wakefulness

Euphoria / Mood Lift ×2

7

euphoria cognitive euphoria motivation enhancement

Focus / Productivity ×2

7

focus enhancement motivation enhancement thought acceleration

⚠ Anxiety / Jitters ×1

10

anxiety increased heart rate teeth grinding tachycardia vasoconstriction

Based on reports from:

Erowid Experience Reports PsychonautWiki 4-MPM

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 5d Half tolerance 3d Baseline ~21d

Values are heuristic, synthesized from community reports and general stimulant tolerance patterns. Frequent consecutive‑day use produces noticeable acute tolerance; allowing 2+ weeks substantially reduces it.