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    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-MTA

    Aliases: Mta, Flatliners, Golden eagle, 4-methylthioamphetamine

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    4-MTA is an extremely dangerous substance with a high fatality rate. It acts as both a potent serotonin releaser and MAO-A inhibitor, creating severe risk of fatal serotonin syndrome and hyperthermia. The slow onset (30-90 minutes) leads to high redosing risk and accidental overdose.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-90 min 1-2 hrs 2-8 hrs 4-12 hrs 24-24 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.0
    Light+ 3/10

    Moderate body load with mild visuals, low headspace

    Visual Intensity ×3
    5
    color enhancement tracers pattern recognition enhancement
    Headspace Depth ×3
    2
    confusion time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    7
    nausea teeth grinding tachycardia increased heart rate
    Empathogen 5.0
    Moderate+ 5/10

    Moderate stimulation and sensory enhancement with mild empathy, low euphoria

    Empathy / Social Openness ×3
    5
    empathy sociability enhancement
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 3.6
    Moderate 4/10

    Strong anxiety/jitters with mild stimulation and focus, low euphoria

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    3
    euphoria
    Focus / Productivity ×2
    4
    analysis enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety tachycardia increased heart rate teeth grinding
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-MTA
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 0h Half tolerance 0d Baseline ~7d

    Human tolerance kinetics are poorly documented due to rarity and high lethality; assume some acute tolerance with slow recovery over days, and significant pharmacodynamic carryover for at least 24–48 h post-use.

    Cross-Tolerances

    MDMA (and other serotonin-releasing entactogens)
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Nausea
    • Headache
    • Tachycardia
    • Increased heart rate
    • Pupil dilation
    • Teeth grinding
    Neutral
    • Hyperthermia
    • Muscle rigidity
    • Decreased appetite
    Positive
    • Empathy
    • Euphoria
    • Sociability enhancement
    • Wakefulness
    • Analysis enhancement
    Negative
    • Agitation
    • Confusion
    • Anxiety
    Neutral
    • Thought acceleration
    • Time distortion
    Positive
    • Tactile enhancement
    • Increased music appreciation
    • Color enhancement
    • Increased libido
    • Tracers
    • Pattern recognition enhancement
    Negative
    • Light sensitivity
    • Dehydration
    • Appetite suppression
    Neutral
    • Increase sexuality

    Combinations TripSit

    4-MTA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki