4-MXP
Aliases: Mxp, 2-mxp, Methoxphenidine, Methoxyphenidine, 2-meo-diphenidine
Summary
Methoxphenidine (commonly called MXP or 2-MXP) is a long-acting dissociative of the diarylethylamine class with particularly extended duration. Oral onset can take 1-2 hours, leading inexperienced users to redose prematurely and experience severe intoxication. Doses above 150 mg have produced severe confusion, blackouts, urinary tract irritation similar to ketamine cystitis, and hospitalizations.
Perspectives
“MXP provides an exciting and interesting experience that almost feels like an abraded and dulled down psychedelic, devoid of color and with a mysterious damper taking hold of my thoughts. Overall it is very buzzy and vibrate-y.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-75mg | 75-120mg | 120-150mg | 150mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 30-60 min | 2-5 hrs | 2-3 hrs | 6-8 hrs |
| Insufflated | 10-45 min | 15-30 min | 2-4 hrs | 1-2 hrs | 6-8 hrs |
| Intravenous | 30-60 min | - | 2-3 hrs | 1-2 hrs | 6-8 hrs |
Effect Profile
30 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 30 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth, mania, and motor impairment with moderate insight
Tolerance
Tolerance Decay
Rapid tolerance build is commonly reported with frequent dissociative use; decay back to baseline typically requires weeks. Values are heuristic aggregates from user reports across dissociatives; specific MXP kinetics are poorly characterized. Avoid consecutive-day use to limit escalation and compulsive redosing.
Cross-Tolerances
Effects
Aggregated from 30 Erowid experience reports