I had to pick up an online order for someone at the grand Macyยs department store right in the heart of the city. I figured I would dose, run my errand, and then walk around the city as I came up. I went to a nearby 7/11, got myself a drink, dosed outside the Macyยs and began the timer. T0:00- Dose taken.
4-PrO-DMT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: O-propionylpsilocin, Psilacetin propanoate ester analogue
Summary
A synthetic psilocin prodrug that converts to 4-HO-DMT in the body via esterase enzymes. User reports indicate classic psilocybin-like effects with potentially heavier body load (nausea, warmth) compared to 4-AcO-DMT. Mouse studies confirm 5-HT2A-mediated psychedelic effects.
Perspectives
“A warm and odd little psychedelic that delivers a fast and furious trip that dazzles the senses. Most notable differences were its short duration, the degree of stimulation, and the jagged angular visuals dominated by warm colors.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-30mg | 30-45mg | 45mg+ |
| Insufflated | 3-10mg | 10-20mg | 20-30mg | 30mg+ |
| Vaporized | 2-6mg | 6-12mg | 12-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 10-40 min | 1-2 hrs | 2-4 hrs | 4-7 hrs |
| Insufflated | 5-15 min | 1-2 hrs | 2-4 hrs | 4-7 hrs |
| Vaporized | - | 1-2 hrs | 2-4 hrs | 4-7 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.1
Strong
6/10
Strong visuals with moderate headspace and body load
Visual Intensity
×3
9
visual geometry
colour enhancement
pattern recognition enhancement
visual distortions
Headspace Depth
×3
6
conceptual thinking
emotion enhancement
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
nausea
vasoconstriction
increased heart rate
Tolerance
Build-up
develops rapidly after a single use
Reset
7โ14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Tolerance develops after one strong experience and decays over about a week, similar to psilocybin. Crossโtolerance is expected across serotonergic tryptamines due to shared 5โHT2A agonism.
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 2
Euphoria
100.0%
70%
Music Enhancement
100.0%
70%
Adverse Effects 2
Anxiety
100.0%
70%
Nausea
100.0%
70%
Combinations
Cross-Check 4-PrO-DMT with another substanceTrip Reports
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
4-PrO-DMT's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for 4-PrO-DMT? Let us know. Reports are reviewed by moderators — this is not posted publicly.