4-PrO-DMT
Aliases: O-propionylpsilocin, Psilacetin propanoate ester analogue
Categories
Summary
A synthetic psilocin prodrug that converts to 4-HO-DMT in the body via esterase enzymes. User reports indicate classic psilocybin-like effects with potentially heavier body load (nausea, warmth) compared to 4-AcO-DMT. Mouse studies confirm 5-HT2A-mediated psychedelic effects. As supply is limited and compound is unscheduled in many regions, reagent testing and proper substance verification is essential. First identified in Sweden in July 2019.
Perspectives
“A warm and odd little psychedelic that delivers a fast and furious trip that dazzles the senses. Most notable differences were its short duration, the degree of stimulation, and the jagged angular visuals dominated by warm colors.”
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 10-30 min | 20-40 min | 1-2 hrs | 2-4 hrs | 1-3 hrs |
| Insufflated | 5-15 min | 10-20 min | 1-2 hrs | 1-2 hrs | 1-2 hrs |
| Vaporized | 1 min | 2-5 min | 30-60 min | 30-90 min | 1-2 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Cross-tolerance
Effects
Positive
- Bodily warmth
- Stimulation
- Physical euphoria
Negative
- Nausea
- Increased heart rate
- Insomnia
- Pupil dilation
- Vasoconstriction
- Sedation
- Dilated pupils
Positive
- Emotion enhancement
- Cognitive euphoria
- Enhanced introspection
- Conceptual thinking
- Euphoria
- Wakefulness
Negative
- Confusion
- Memory suppression
- Anxiety
- Time distortion
Positive
- Visual geometry
- Colour enhancement
- Pattern recognition enhancement
- Color enhancement
- Increased music appreciation
- Tactile enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Visual distortions