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    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-PrO-DMT Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 3 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: O-propionylpsilocin, Psilacetin propanoate ester analogue

    Psychedelic Research-chemical

    Summary dose.wiki

    A synthetic psilocin prodrug that converts to 4-HO-DMT in the body via esterase enzymes. User reports indicate classic psilocybin-like effects with potentially heavier body load (nausea, warmth) compared to 4-AcO-DMT. Mouse studies confirm 5-HT2A-mediated psychedelic effects.

    Perspectives

    “All that aside it is a warm and odd little psychedelic that delivers a fast and furious trip that dazzles the senses.”

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Vendors commonly supply the fumarate salt. Potency by weight depends on salt stoichiometry. If 1:1 base:fumaric acid, freebase fraction β‰ˆ0.69; if 2:1, freebase fraction β‰ˆ0.82. Without a certificate of analysis (COA), assume 0.70–0.80 base-equivalent and titrate cautiously. Isomer Design lists freebase MW 260.33 g/mol; fumaric acid adds 116.07 g/mol per mole. If your sample label is ambiguous, weigh as salt and start on the low end. Stability is better as fumarate; store airtight, desiccated, dark, cold to reduce hydrolysis to psilocin. Fumarate salts are water‑soluble and generally sting less than HCl salts, but intranasal use can still cause irritation. Because the come‑up is faster and steeper, use very small first lines or pre-dilute for volumetric dosing to avoid overshooting. Avoid if you have chronic nasal issues. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-30mg 30-45mg 45mg+
    Insufflated 3-10mg 10-20mg 20-30mg 30mg+
    Vaporized 2-6mg 6-12mg 12-20mg 20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 10-30 min 20-40 min 1-2 hrs 2-4 hrs 1-3 hrs 3.5-7.17 hrs
    Insufflated 5-15 min 10-20 min 1-2 hrs 1-2 hrs 1-2 hrs 2.25-4.58 hrs
    Vaporized 36 sec 2-5 min 30-60 min 30-90 min 1-2 hrs 1.04-2.59 hrs

    Effect Profile

    3 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.1
    Strong 6/10

    Strong visuals with moderate headspace and body load

    Visual Intensity ×3
    9
    visual geometry colour enhancement pattern recognition enhancement visual distortions
    Headspace Depth ×3
    6
    conceptual thinking emotion enhancement time distortion confusion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea vasoconstriction increased heart rate
    Based on reports from:
    Effect Index Sonic Phantoms Effect Index A Pleasant Morning Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-PrO-DMT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-PrO-DMT (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-PrO-DMT
    Unit
    mg
    Description 
    4-PrO-DMT
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 Β· light 5-15 Β· common 15-30 Β· strong 30-45 Β· heavy 45+
Insufflated dose (mg): threshold 3 Β· light 3-10 Β· common 10-20 Β· strong 20-30 Β· heavy 30+
Vaporized dose (mg): threshold 2 Β· light 2-6 Β· common 6-12 Β· strong 12-20 Β· heavy 20+

Oral duration: onset 10-30m Β· come-up 20-40m Β· peak 1-2h Β· offset 2-4h Β· total 3.5-7.17h Β· after-effects 1-3h
Insufflated duration: onset 5-15m Β· come-up 10-20m Β· peak 1-2h Β· offset 1-2h Β· total 2.25-4.58h Β· after-effects 1-2h
Vaporized duration: onset 36s Β· come-up 2-5m Β· peak 0.5-1h Β· offset 0.5-1.5h Β· total 1.04-2.59h Β· after-effects 1-2h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 22.5 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    Tolerance develops after one strong experience and decays over about a week, similar to psilocybin. Cross‑tolerance is expected across serotonergic tryptamines due to shared 5‑HT2A agonism.

    Cross-Tolerances

    psilocybin / psilocin
    90%
    other 4‑substituted tryptamines (4‑AcO‑DMT, 4‑HO‑MET)
    60%

    Effects Erowid

    Aggregated from 3 Erowid experience reports

    Positive Effects 2

    Euphoria 100.0% 70%
    Music Enhancement 100.0% 70%

    Adverse Effects 2

    Anxiety 100.0% 70%
    Nausea 100.0% 70%

    Combinations

    Cross-Check 4-PrO-DMT with another substance

    Trip Reports Effect Index

    Sonic Phantoms nervewing A Pleasant Morning utheraptor

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 neutral visit
    Radiance of the Sonic Phantoms neutral exp #113867

    I had to pick up an online order for someone at the grand MacyΒ’s department store right in the heart of the city. I figured I would dose, run my errand, and then walk around the city as I came up. I went to a nearby 7/11, got myself a drink, dosed outside the MacyΒ’s and began the timer. T0:00- Dose taken.

    nervewing · 25 mg oral / smoked / smoked / smoked
    4-PrO-DMT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    πŸ“˜ Experience Reports πŸ“– dose.wiki πŸ“– PsychonautWiki