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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Pro-MET Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Psychedelic Research-chemical

    Summary dose.wiki

    4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges triangulated from 4‑HO‑MET human data (Erowid) plus multiple 4‑PrO‑MET pellet reports indicating variable potency; start low and titrate. Community reports describe 'sneaky' waves on the come‑up. User reports; no formal studies. Not recommended. For 4‑HO‑MET, intranasal produces a faster, shorter, more abrupt experience with rougher come‑ups; there is no specific safety/PK data for 4‑PrO‑MET. If someone proceeds anyway, treating potency as similar to oral 4‑HO‑MET helps avoid accidental overdosing. User reports; caution warranted. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 3-7mg 7-15mg 15-25mg 25mg+
    Insufflated 5-10mg 8-15mg 12-20mg 20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1-3 hrs 1-2 hrs 1-6 hrs 2.83-7 hrs
    Insufflated 20-60 min - 1-3 hrs 1-2 hrs 1-6 hrs 4-7 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.6
    Moderate+ 5/10

    Moderate visuals and body load with mild headspace

    Visual Intensity ×3
    6
    color enhancement drifting pattern recognition enhancement visual acuity enhancement
    Headspace Depth ×3
    5
    conceptual thinking thought connectivity time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea temperature regulation suppression increased heart rate
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Pro-MET there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Pro-MET (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Pro-MET
    Unit
    mg
    Description 
    4-Pro-MET
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2 · light 3-7 · common 7-15 · strong 15-25 · heavy 25+
Insufflated dose (mg): threshold 2-5 · light 5-10 · common 8-15 · strong 12-20 · heavy 20+

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-3h · offset 1-2h · total 2.83-7h · after-effects 1-6h
Insufflated duration: onset 0.33-1h · peak 1-3h · offset 1-2h · total 4-7h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 11 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 7d Baseline ~14d

    Values are heuristic based on community use patterns of 4‑subbed tryptamines; no controlled human data. Avoid consecutive‑day use; waiting 7–14 days typically restores near‑baseline response. Data quality: anecdotal.

    Cross-Tolerances

    4‑HO‑MET (metocin)
    100%
    4‑AcO‑MET
    80%
    Psilocin/psilocybin
    80%
    Other classic psychedelics (e.g., LSD)
    50%

    Effects dose.wiki

    Positive
    • Creativity enhancement
    • Stimulation
    Negative
    • Nausea
    • Temperature regulation suppression
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    Neutral
    • Excessive yawning
    • Muscle contractions
    • Sedation
    Positive
    • Euphoria
    • Analysis enhancement
    • Conceptual thinking
    • Immersion enhancement
    • Thought connectivity
    • Wakefulness
    • Cognitive euphoria
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Color enhancement
    • Pattern recognition enhancement
    • Visual acuity enhancement
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Drifting

    Combinations

    Cross-Check 4-Pro-MET with another substance

    4-Pro-MET's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki