4-Pro-MET
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-7mg | 7-15mg | 15-25mg | 25mg+ |
| Insufflated | 5-10mg | 8-15mg | 12-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 1-2 hrs | 4-7 hrs |
| Insufflated | 20-60 min | 1-3 hrs | 1-2 hrs | 4-7 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals and body load with mild headspace
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Values are heuristic based on community use patterns of 4‑subbed tryptamines; no controlled human data. Avoid consecutive‑day use; waiting 7–14 days typically restores near‑baseline response. Data quality: anecdotal.
Cross-Tolerances
Effects
- Creativity enhancement
- Stimulation
- Nausea
- Temperature regulation suppression
- Increased heart rate
- Insomnia
- Pupil dilation
- Excessive yawning
- Muscle contractions
- Sedation
- Euphoria
- Analysis enhancement
- Conceptual thinking
- Immersion enhancement
- Thought connectivity
- Wakefulness
- Cognitive euphoria
- Anxiety
- Compulsive redosing
- Time distortion
- Color enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Increased music appreciation
- Tactile enhancement
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
- Drifting
Combinations
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