Summary
4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model. Compared with 4-HO-MET, some users describe slightly slower onset and equal or lower mg-for-mg potency; others report unexpectedly strong visuals from a single pellet, suggesting either under- or over-filled tablets or uneven distribution of active compound. A conservative harm-reduction approach is to treat 4-PrO-MET as roughly equipotent to 4-AcO-MET and somewhat less potent than 4-HO-MET, keeping first trials at or below 5-7 mg.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-3 hrs | 1-2 hrs | 1-6 hrs |
Tolerance
Effects
- Creativity enhancement
- Stimulation
- Nausea
- Temperature regulation suppression
- Increased heart rate
- Insomnia
- Pupil dilation
- Excessive yawning
- Muscle contractions
- Sedation
- Euphoria
- Analysis enhancement
- Conceptual thinking
- Immersion enhancement
- Thought connectivity
- Wakefulness
- Cognitive euphoria
- Anxiety
- Compulsive redosing
- Time distortion
- Color enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Increased music appreciation
- Tactile enhancement
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
- Drifting