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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-Pro-MET Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 30 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Psychedelic Research-chemical

    Summary dose.wiki

    4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model.

    Dose Information Drugs.Wiki

    Dose basis. Oral: Ranges triangulated from 4‑HO‑MET human data (Erowid) plus multiple 4‑PrO‑MET pellet reports indicating variable potency; start low and titrate. Community reports describe 'sneaky' waves on the come‑up. User reports; no formal studies. Insufflated: Not recommended. For 4‑HO‑MET, intranasal produces a faster, shorter, more abrupt experience with rougher come‑ups; there is no specific safety/PK data for 4‑PrO‑MET. If someone proceeds anyway, treating potency as similar to oral 4‑HO‑MET helps avoid accidental overdosing. User reports; caution warranted. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 3-7mg 7-15mg 15-25mg 25mg+
    Insufflated 5-10mg 8-15mg 12-20mg 20mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — Drugs.Wiki

    Insufflated

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1-3 hrs 1-2 hrs 1-6 hrs 2.83-7 hrs
    Insufflated 20-60 min - 1-3 hrs 1-2 hrs 1-6 hrs 4-7 hrs

    Effect Profile

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.6
    Moderate+ 5/10

    Moderate visuals with moderate body load, mild headspace

    Visual Intensity ×3
    6
    color enhancement drifting pattern recognition enhancement visual acuity enhancement
    Headspace Depth ×3
    5
    conceptual thinking thought connectivity time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea temperature regulation suppression increased heart rate
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 6h Half tolerance 7d Baseline ~14d

    Values are heuristic based on community use patterns of 4‑subbed tryptamines; no controlled human data. Avoid consecutive‑day use; waiting 7–14 days typically restores near‑baseline response. Data quality: anecdotal.

    Cross-Tolerances

    4‑HO‑MET (metocin)
    4‑AcO‑MET
    Psilocin/psilocybin
    Other classic psychedelics (e.g., LSD)

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 4-Pro-MET with another substance

    4-Pro-MET's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4-Pro-MET there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4-Pro-MET (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4-Pro-MET
    Unit
    mg
    Description 
    4-Pro-MET
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 2 · light 3-7 · common 7-15 · strong 15-25 · heavy 25+
Insufflated dose (mg): threshold 2-5 · light 5-10 · common 8-15 · strong 12-20 · heavy 20+

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1-3h · offset 1-2h · total 2.83-7h · after-effects 1-6h
Insufflated duration: onset 0.33-1h · peak 1-3h · offset 1-2h · total 4-7h · after-effects 1-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 11 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.