4-Pro-MET
Summary
4-PrO-MET is marketed in Europe as pressed pellets labeled 15-20 mg; multiple user reports indicate substantial potency variability between batches, so titration from 2-3 mg is prudent. A German-language thread documents perceived microdose at 0.5-3 mg, light 4-8 mg, and 8 mg+ as very strong; half of a 15 mg pellet (approximately 7.5 mg) ranged from mild to quite strong depending on the commenter, underscoring variability in pressing and individual sensitivity. As an O-propionyl ester at the 4-position, 4-PrO-MET is expected to hydrolyze to 4-HO-MET in vivo; human data are absent, but analogous work with 4-PrO-DMT demonstrates psychedelic activity in animals and supports the prodrug model.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-3 hrs | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals and body load with mild headspace
Tolerance
Tolerance Decay
Values are heuristic based on community use patterns of 4‑subbed tryptamines; no controlled human data. Avoid consecutive‑day use; waiting 7–14 days typically restores near‑baseline response. Data quality: anecdotal.
Cross-Tolerances
Effects
- Creativity enhancement
- Stimulation
- Nausea
- Temperature regulation suppression
- Increased heart rate
- Insomnia
- Pupil dilation
- Excessive yawning
- Muscle contractions
- Sedation
- Euphoria
- Analysis enhancement
- Conceptual thinking
- Immersion enhancement
- Thought connectivity
- Wakefulness
- Cognitive euphoria
- Anxiety
- Compulsive redosing
- Time distortion
- Color enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Increased music appreciation
- Tactile enhancement
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
- Drifting