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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4,4-DMAR

    Aliases: 4,4-dmap, Serotoni, Serotoni, para-methyl-4-methylaminorex

    Psychedelic Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki TripSit

    4,4'-DMAR is an extremely potent stimulant that is 5-10 times more potent than MDMA as a monoamine releasing agent. It has pharmacological properties comparable to MDMA but with higher potency and longer duration. Unlike many amphetamines, 4,4'-DMAR lacks TAAR1 agonism, meaning it does not auto-inhibit its own effects, potentially making it more dangerous.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 30-60mg 60-120mg 120-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects
    Oral 30-60 min 2-4 hrs 2-4 hrs 24-24 hrs
    Insufflated 30-60 min 2-4 hrs 2-4 hrs 24-24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 1.1
    Threshold 1/10

    Moderate body load with low visuals

    Visual Intensity ×3
    2
    visual enhancement
    Headspace Depth ×3
    0
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    7
    vasoconstriction teeth grinding bruxism increased heart rate
    Empathogen 4.1
    Moderate 4/10

    Strong stimulation with moderate sensory enhancement, low euphoria and empathy

    Empathy / Social Openness ×3
    2
    increased sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    10
    increased energy stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement visual enhancement increased libido
    Stimulant 6.6
    Strong+ 7/10

    Strong anxiety/jitters, stimulation, and focus with mild euphoria

    Stimulation / Energy ×3
    9
    increased energy stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    8
    enhanced focus focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding bruxism vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4,4-DMAR
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Increased energy
    • Stimulation
    Negative
    • Increased heart rate
    • Teeth grinding
    • Vasoconstriction
    • Insomnia
    • Pupil dilation
    • Increased blood pressure
    • Increased perspiration
    • Bruxism
    Positive
    • Euphoria
    • Enhanced focus
    • Increased sociability
    • Alertness enhancement
    • Focus enhancement
    • Motivation enhancement
    • Wakefulness
    Negative
    • Anxiety
    Neutral
    • Empathogenic effects
    • Talkativeness
    Positive
    • Increased libido
    • Increased music appreciation
    • Visual enhancement
    • Tactile enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    4,4-DMAR's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki