4,4-DMAR
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Tentative
- classified Research-chemical
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4,4-dmap, Serotoni, Serotoni, para-methyl-4-methylaminorex
Summary
4,4'-DMAR (para-methyl-4-methylaminorex) is a stimulant of the amphetamine class. It acts as a monoamine releasing agent, with pharmacological properties comparable to MDMA. It is extremely potent, estimated at 5-10 times more potent than MDMA as a monoamine releasing agent, and has a longer duration. Unlike many amphetamines, 4,4'-DMAR lacks TAAR1 agonism, meaning it does not auto-inhibit its own effects, potentially making it more dangerous.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-60mg | 60-120mg | 120-200mg | 200mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 2-4 hrs | 4.5-9 hrs |
| Insufflated | 30-60 min | 2-4 hrs | 2-4 hrs | 4.5-9 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate body load with low visuals
Strong stimulation with moderate sensory enhancement, low euphoria and empathy
Strong anxiety/jitters, stimulation, and focus with mild euphoria
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 4,4-DMAR there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
4,4-DMAR Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 30-60 · common 60-120 · strong 120-200 · heavy 200+ Insufflated dose (mg): threshold 1 Oral duration: onset 0.5-1h · peak 2-4h · offset 2-4h · total 4.5-9h · after-effects 24h Insufflated duration: onset 0.5-1h · peak 2-4h · offset 2-4h · total 4.5-9h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 90 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Increased energy
- Stimulation
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Insomnia
- Pupil dilation
- Increased blood pressure
- Increased perspiration
- Bruxism
- Euphoria
- Enhanced focus
- Increased sociability
- Alertness enhancement
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Anxiety
- Empathogenic effects
- Talkativeness
- Increased libido
- Increased music appreciation
- Visual enhancement
- Tactile enhancement
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Double vision
- Dulled perception
Combinations
Cross-Check 4,4-DMAR with another substanceHelpful Links
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