4,4-DMAR
Aliases: 4,4-dmap, Serotoni, Serotoni, para-methyl-4-methylaminorex
Categories
Summary
4,4'-DMAR is an extremely potent stimulant that is 5-10 times more potent than MDMA as a monoamine releasing agent. It has pharmacological properties comparable to MDMA but with higher potency and longer duration. Unlike many amphetamines, 4,4'-DMAR lacks TAAR1 agonism, meaning it does not auto-inhibit its own effects, potentially making it more dangerous. It has been associated with at least 31 fatalities in Europe, often when combined with other substances. Serious health risks include serotonin syndrome, hyperthermia, seizures, cardiovascular complications, and pulmonary hypertension.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-60mg | 60-120mg | 120-200mg | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 2-4 hrs | 24 hrs |
| Insufflated | 30-60 min | 2-4 hrs | 2-4 hrs | 24 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Increased energy
- Stimulation
Negative
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Insomnia
- Pupil dilation
- Increased blood pressure
- Increased perspiration
- Bruxism
Positive
- Euphoria
- Enhanced focus
- Increased sociability
- Alertness enhancement
- Focus enhancement
- Motivation enhancement
- Wakefulness
Negative
- Anxiety
- Empathogenic effects
- Talkativeness
Positive
- Increased libido
- Increased music appreciation
- Visual enhancement
- Tactile enhancement
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Double vision
- Dulled perception