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    4F-MDMB-BINACA molecular structure

    4F-MDMB-BINACA Stats & Data

    4f-adb Mdmb-4f-binaca 4f-mdmb-butinaca
    NPS DataHub
    MW363.43
    FormulaC19H26FN3O3
    IUPACmethyl 2-{[1-(4-fluorobutyl)-1H-indazol-3-yl]formamido}-3,3-dimethylbutanoate
    SMILESFCCCCn1nc(C(=O)NC(C(=O)OC)C(C)(C)C)c2ccccc12
    InChIKeyGZGKSDAMWRWYOZ-UHFFFAOYSA-N
    Cannabinoids; 2020/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2021/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2022/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen
    Chemical Class Cannabinoid
    Psychoactive Class Psychedelic
    Half-Life Parent compound: human data limited; urinary studies identify rapid formation of metabolites (e.g., 4‑OH‑MDMB‑BINACA and carboxylic acid derivatives). Effective impairment can outlast the peak for several hours due to high potency and lipophilicity.

    Effect Profile

    Curated
    Psychedelic 3.2

    Moderate body load with mild auditory effects, low visuals and headspace

    Visual Intensity×3
    3
    Headspace Depth×3
    3
    Auditory Effects×1
    4
    Body Load / Somatic Effects×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Parent compound: human data limited; urinary studies identify rapid formation of metabolites (e.g., 4‑OH‑MDMB‑BINACA and carboxylic acid derivatives). Effective impairment can outlast the peak for several hours due to high potency and lipophilicity.
    Addiction Potential
    High. Frequent use is linked to rapid tolerance, compulsive redosing and a clinically significant withdrawal syndrome (agitation, insomnia, nausea/vomiting, tachycardia, seizures, and psychosis) more severe and unpredictable than with natural cannabis; risk rises with daily/heavy exposure.

    Cross-Tolerances

    Cannabis (THC)
    30% ●○○
    Other synthetic cannabinoids
    70% ●●○

    Harm Reduction

    drugs.wiki

    Why add this: 4F‑MDMB‑BINACA belongs to a class of highly potent synthetic cannabinoids; EUDA reports emphasise that even low doses can cause severe poisoning and that products may be mis‑sold or adulterated. Therefore, precise measurement and conservative titration are essential. EUDA and case‑series on SCRA critical illness state there is no specific antidote; management is supportive with benzodiazepines for agitation/seizures and cardiorespiratory monitoring. EUDA also documents ‘hot‑spot’ risks from unevenly sprayed plant material or paper, and widespread SCRA adulteration of cannabis products and edibles; this justifies strong warnings against DIY spraying and against trusting appearance/branding. Polysubstance use is common and increases harms; combining CNS depressants (alcohol, opioids, benzodiazepines) elevates risk of coma/respiratory events, while stimulants add cardiovascular strain to a class already linked to tachycardia, hypertension, seizures and psychosis. Withdrawal and dependence are well‑documented for SCRAs and are often more severe than with cannabis, warranting the high addiction‑risk classification. Detectable urinary metabolites (e.g., 4‑OH‑MDMB‑BINACA; acid hydrolysis products) explain why impairment may persist beyond the peak even as parent levels fall. In emergencies: avoid redosing; seek help for chest pain, seizures, loss of consciousness, or uncontrollable agitation; naloxone will not reverse SCRA effects, but should still be given if opioid exposure is suspected (mixed supplies are increasingly documented). Prefer not to drive or operate machinery the same day; impairment can outlast the subjective high.

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