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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    4F-MDMB-BINACA

    Aliases: 4f-adb, Mdmb-4f-binaca, 4f-mdmb-butinaca

    Psychedelic Research-chemical Cannabinoid

    Summary TheDrug.Wiki

    4F-MDMB-BINACA is one of the most potent synthetic cannabinoids currently encountered (EC50 = 7.39 nM at CB1). A single match-head sized crystal can exceed a strong dose; always use a milligram-scale and dissolve for volumetric dosing if possible. Do NOT eyeball doses.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Smoked 0-1 min 5-20 min 30-60 min -
    Oral 0-1 min 5-20 min 30-60 min 1-3 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.2
    Light+ 3/10

    Moderate body load with mild auditory effects, low visuals and headspace

    Visual Intensity ×3
    3
    color enhancement visual distortions
    Headspace Depth ×3
    3
    thought connectivity time distortion
    Auditory Effects ×1
    4
    auditory distortions
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea tachycardia sweating increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4F-MDMB-BINACA
    View methodology →

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Cross-Tolerances

    Cannabis (THC)
    30%
    Other synthetic cannabinoids
    70%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    Negative
    • Profound dry mouth
    • Tachycardia
    • Nausea
    • Sweating
    • Dry mouth
    • Increased heart rate
    Neutral
    • Chills
    • Spontaneous bodily sensations
    • Sedation
    Positive
    • Euphoria
    • Thought connectivity
    Negative
    • Short-term memory suppression
    • Motor control loss
    • Anxiety
    • Paranoia
    • Afterglow fatigue
    Neutral
    • Rapid intense cannabis-like intoxication
    • Euphoria or dysphoria
    • Time distortion
    Positive
    • Color enhancement
    • Appetite enhancement
    • Perception of bodily lightness
    Negative
    • Dehydration
    Neutral
    • Closed-eye imagery
    • Visual snow
    • Auditory distortions
    • Visual distortions
    • Appetite intensification
    • Changes in felt gravity

    Combinations TripSit

    4F-MDMB-BINACA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki