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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    4F-MDMB-BINACA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4f-adb, Mdmb-4f-binaca, 4f-mdmb-butinaca

    Psychedelic Research-chemical Cannabinoid

    Summary TheDrug.Wiki

    4F-MDMB-BINACA is one of the most potent synthetic cannabinoids currently encountered (EC50 = 7.39 nM at CB1). A single match-head sized crystal can exceed a strong dose; always use a milligram-scale and dissolve for volumetric dosing if possible. Do NOT eyeball doses.

    Dose Information TheDrug.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    ROA Light Common Strong Heavy
    Smoked 0.1-0.3mg 0.3-0.8mg 0.8-1.5mg 1.5mg+
    Oral 0.05-0.15mg 0.15-0.4mg 0.4-0.8mg 0.8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked - 5-20 min 30-60 min 1-3 hrs 1-2 hrs
    Oral 15-40 min 5-20 min 30-60 min 1-3 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.2
    Light+ 3/10

    Moderate body load with mild auditory effects, low visuals and headspace

    Visual Intensity ×3
    3
    color enhancement visual distortions
    Headspace Depth ×3
    3
    thought connectivity time distortion
    Auditory Effects ×1
    4
    auditory distortions
    ⚠ Body Load / Somatic Effects ×1
    6
    nausea tachycardia sweating increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4F-MDMB-BINACA
    View methodology →

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    User reports and surveys suggest tolerance escalates quickly with daily/binge use and recovers over weeks of abstinence; quantitative human data are limited.

    Cross-Tolerances

    Cannabis (THC)
    30%
    Other synthetic cannabinoids
    70%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    Negative
    • Profound dry mouth
    • Tachycardia
    • Nausea
    • Sweating
    • Dry mouth
    • Increased heart rate
    Neutral
    • Chills
    • Spontaneous bodily sensations
    • Sedation
    Positive
    • Euphoria
    • Thought connectivity
    Negative
    • Short-term memory suppression
    • Motor control loss
    • Anxiety
    • Paranoia
    • Afterglow fatigue
    Neutral
    • Rapid intense cannabis-like intoxication
    • Euphoria or dysphoria
    • Time distortion
    Positive
    • Color enhancement
    • Appetite enhancement
    • Perception of bodily lightness
    Negative
    • Dehydration
    Neutral
    • Closed-eye imagery
    • Visual snow
    • Auditory distortions
    • Visual distortions
    • Appetite intensification
    • Changes in felt gravity

    Combinations TripSit

    Cross-Check 4F-MDMB-BINACA with another substance

    4F-MDMB-BINACA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki