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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    4F-MDMB-BINACA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4f-adb, Mdmb-4f-binaca, 4f-mdmb-butinaca

    Research-chemical Cannabinoid

    Summary dose.wiki

    4F-MDMB-BINACA is one of the most potent synthetic cannabinoids currently encountered (EC50 = 7.39 nM at CB1). A single match-head sized crystal can exceed a strong dose; always use a milligram-scale and dissolve for volumetric dosing if possible. Do NOT eyeball doses.

    Dose Information Drugs.Wiki

    Dose basis. Smoked: Extremely potent; dose-response can vary several-fold between batches. Always use a calibrated 0.001 g (1 mg) scale and preferably prepare a volumetric solution to measure microgram-level doses. Avoid ‘eyeballing’ crystals and avoid spraying DIY herbal mixes without laboratory-grade homogenisation—uneven ‘hot-spots’ have caused severe poisonings. Start with one tiny inhalation and wait at least 15–20 minutes before considering any redose. Oral: Oral onset is delayed and duration longer; overdosing is common when redosing too early. Because synthetic cannabinoids have been detected in mis-sold ‘edibles’ and vaping products, treat unknown oral/vape products with extreme caution. Volumetric dosing is strongly advised if using neat material; avoid capsules with unverified microgram-level fills. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Smoked 0.1-0.3mg 0.3-0.8mg 0.8-1.5mg 1.5mg+
    Oral 0.05-0.15mg 0.15-0.4mg 0.4-0.8mg 0.8mg+
    Light Common Strong Heavy
    Sources

    Smoked

    Dose ladder — Drugs.Wiki

    Oral

    Dose ladder — Drugs.Wiki

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked 0-1 min 5-20 min 30-60 min - 35-81 min
    Oral 15-40 min 45-90 min 1-2 hrs 1-3 hrs 2-4 hrs

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    User reports and surveys suggest tolerance escalates quickly with daily/binge use and recovers over weeks of abstinence; quantitative human data are limited.

    Cross-Tolerances

    Cannabis (THC)
    Other synthetic cannabinoids

    Effects dose.wiki

    Positive
    Negative
    Neutral
    Positive
    Negative
    Neutral
    • Rapid intense cannabis-like intoxication
    • Euphoria or dysphoria
    Positive
    Negative
    Neutral

    Combinations

    Cross-Check 4F-MDMB-BINACA with another substance

    4F-MDMB-BINACA's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📖 dose.wiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4F-MDMB-BINACA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4F-MDMB-BINACA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4F-MDMB-BINACA
    Unit
    mg
    Description 
    4F-MDMB-BINACA
Source: SubstanceSearch (substancesearch.com)

Smoked dose (mg): threshold 0.1 · light 0.1-0.3 · common 0.3-0.8 · strong 0.8-1.5 · heavy 1.5+
Oral dose (mg): threshold 0.05 · light 0.05-0.15 · common 0.15-0.4 · strong 0.4-0.8 · heavy 0.8+

Smoked duration: onset 0-1m · peak 5-20m · offset 0.5-1h · total 0.58-1.35h
Oral duration: onset 15-40m · peak 0.75-1.5h · offset 1-2h · total 2-4h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 0.55 mg (Smoked).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.