4F-MDMB-BINACA
Aliases: 4f-adb, Mdmb-4f-binaca, 4f-mdmb-butinaca
Categories
Summary
4F-MDMB-BINACA is one of the most potent synthetic cannabinoids currently encountered (EC50 = 7.39 nM at CB1). A single match-head sized crystal can exceed a strong dose; always use a milligram-scale and dissolve for volumetric dosing if possible. Do NOT eyeball doses. Numerous severe poisonings and several fatalities have been linked to amounts below 2 mg, particularly when sprayed unevenly onto herbal material or mixed into counterfeit cannabis flower. Acute toxicity can involve severe tachycardia, hypertension or hypotension, seizures, loss of consciousness, acute psychosis, and respiratory depression.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Smoked | 0-1 min | 5-20 min | 30-60 min | - |
| Oral | 0-1 min | 5-20 min | 30-60 min | 1-3 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
Negative
- Profound dry mouth
- Tachycardia
- Nausea
- Sweating
- Dry mouth
- Increased heart rate
- Chills
- Spontaneous bodily sensations
- Sedation
Positive
- Euphoria
- Thought connectivity
Negative
- Short-term memory suppression
- Motor control loss
- Anxiety
- Paranoia
- Afterglow fatigue
- Rapid intense cannabis-like intoxication
- Euphoria or dysphoria
- Time distortion
Positive
- Color enhancement
- Appetite enhancement
- Perception of bodily lightness
Negative
- Dehydration
- Closed-eye imagery
- Visual snow
- Auditory distortions
- Visual distortions
- Appetite intensification
- Changes in felt gravity