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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    4F-MDMB-BINACA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 4f-adb, Mdmb-4f-binaca, 4f-mdmb-butinaca

    Research-chemical Cannabinoid

    Summary dose.wiki

    4F-MDMB-BINACA is one of the most potent synthetic cannabinoids currently encountered (EC50 = 7.39 nM at CB1). A single match-head sized crystal can exceed a strong dose; always use a milligram-scale and dissolve for volumetric dosing if possible. Do NOT eyeball doses.

    Dose Information dose.wiki Drugs.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    Dose basis. Extremely potent; dose-response can vary several-fold between batches. Always use a calibrated 0.001 g (1 mg) scale and preferably prepare a volumetric solution to measure microgram-level doses. Avoid ‘eyeballing’ crystals and avoid spraying DIY herbal mixes without laboratory-grade homogenisation—uneven ‘hot-spots’ have caused severe poisonings. Start with one tiny inhalation and wait at least 15–20 minutes before considering any redose. Oral onset is delayed and duration longer; overdosing is common when redosing too early. Because synthetic cannabinoids have been detected in mis-sold ‘edibles’ and vaping products, treat unknown oral/vape products with extreme caution. Volumetric dosing is strongly advised if using neat material; avoid capsules with unverified microgram-level fills. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Smoked 0.1-0.3mg 0.3-0.8mg 0.8-1.5mg 1.5mg+
    Oral 0.05-0.15mg 0.15-0.4mg 0.4-0.8mg 0.8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked 0-1 min 5-20 min 30-60 min - 35-81 min
    Oral 0-1 min 5-20 min 30-60 min 1-3 hrs 35-81 min

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 4F-MDMB-BINACA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "4F-MDMB-BINACA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    4F-MDMB-BINACA
    Unit
    mg
    Description 
    4F-MDMB-BINACA
Source: SubstanceSearch (substancesearch.com)

Smoked dose (mg): threshold 0.1 · light 0.1-0.3 · common 0.3-0.8 · strong 0.8-1.5 · heavy 1.5+
Oral dose (mg): threshold 0.05 · light 0.05-0.15 · common 0.15-0.4 · strong 0.4-0.8 · heavy 0.8+

Smoked duration: onset 0-1m · peak 5-20m · offset 0.5-1h · total 0.58-1.35h
Oral duration: onset 0-1m · peak 5-20m · offset 0.5-1h · total 0.58-1.35h · after-effects 1-3h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 0.55 mg (Smoked).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Half tolerance 14d Baseline ~28d

    User reports and surveys suggest tolerance escalates quickly with daily/binge use and recovers over weeks of abstinence; quantitative human data are limited.

    Cross-Tolerances

    Cannabis (THC)
    30%
    Other synthetic cannabinoids
    70%

    Effects dose.wiki

    Positive
    • Pain relief
    Negative
    • Profound dry mouth
    • Tachycardia
    • Nausea
    • Sweating
    • Dry mouth
    • Increased heart rate
    Neutral
    • Chills
    • Spontaneous bodily sensations
    • Sedation
    Positive
    • Euphoria
    • Thought connectivity
    Negative
    • Short-term memory suppression
    • Motor control loss
    • Anxiety
    • Paranoia
    • Afterglow fatigue
    Neutral
    • Rapid intense cannabis-like intoxication
    • Euphoria or dysphoria
    • Time distortion
    Positive
    • Color enhancement
    • Appetite enhancement
    • Perception of bodily lightness
    Negative
    • Dehydration
    Neutral
    • Closed-eye imagery
    • Visual snow
    • Auditory distortions
    • Visual distortions
    • Appetite intensification
    • Changes in felt gravity

    Combinations

    Cross-Check 4F-MDMB-BINACA with another substance

    4F-MDMB-BINACA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki