5-Bromo-DMT - Substance Search

Summary TheDrug.Wiki TripSit

Naturally occurs in marine sponges (Smenospongia aurea, Verongula rigida) and in the skin of the Caribbean reef toad. In rodent studies it produced antidepressant-like and anxiolytic behaviors at non-stimulant doses and acted as a 5-HT1A partial agonist while showing little psychedelic activity, which may explain its unusually sedating, dreamy character compared with DMT. Very sparse human data; user reports describe warm body load, closed-eye visuals, and pronounced relaxation rather than intense hallucinations.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Vaporized	10-25mg	25-35mg	35-65mg	65mg+
Vapourized	10-25mg	25-35mg	35-65mg	65mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Peak	Total
Oral	1-2 hrs	-	1-2 hrs
Vapourized	1-1 min	15-90 min	0.27-1.52 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 5.4

Moderate+ 5/10

Moderate visuals with mild headspace

Visual Intensity ×3

7

colour enhancement pattern recognition enhancement visual distortions

Headspace Depth ×3

4

introspection emotion enhancement time distortion

Auditory Effects ×1

0

⚠ Body Load / Somatic Effects ×1

0

Based on reports from:

Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 5-Bromo-DMT

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1h Half tolerance 1d Baseline ~7d

Rapid acute tolerance like other serotonergic psychedelics is plausible, with most sensitivity returning over ~1 week; evidence in humans is anecdotal. Cross‑tolerance across classic psychedelics is well‑described (LSD↔psilocybin), but specific data for 5‑Br‑DMT are lacking. Treat intervals of ≥7 days as a conservative baseline.