Summary
5-Cl-AMT (5-chloro-ฮฑ-methyltryptamine; PAL-542) combines three properties with harm-reduction implications: it is a serotonin-dopamine releasing agent, a potent 5-HT2A agonist, and an in vitro MAO-A inhibitor. Treat it as an MAOI during the session window even though clinical reversibility is not established. Start with a microtest of 0.5-1 mg to gauge sensitivity; community trials report activity at 1-2 mg and full days' worth of effects from 8-12 mg. Because the come-up is slow and the duration long, redosing is usually unnecessary and can produce a late, heavy body load. Volumetric dosing is strongly advised so that sub-1 mg adjustments are possible; weigh at least 10-20 mg on a 0.001 g scale, dissolve to make 1 mg/mL or 0.5 mg/mL, and measure with an oral syringe.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 4-8 hrs | 4-8 hrs | 12-48 hrs |
Tolerance
Effects
- Stimulation
- Pupil dilation
- Mild tremor or jaw tension
- Nystagmus
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Insomnia
- Increased perspiration
- Increased body temperature
- Entactogenic warmth and sociability
- Alertness enhancement
- Euphoria
- Wakefulness
- Motivation enhancement
- Increased sociability
- Anxiety
- Time distortion
- Talkativeness
- Thought acceleration
- Color enhancement
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
- Spontaneous physical sensations