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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  This substance involves MAOI activity. Dangerous interactions can occur with many common foods and medications. Research contraindications thoroughly.

    5-Cl-AMT

    Aliases: Pal-542

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki

    5-Cl-AMT (5-chloro-ฮฑ-methyltryptamine; PAL-542) combines three properties with harm-reduction implications: it is a serotonin-dopamine releasing agent, a potent 5-HT2A agonist, and an in vitro MAO-A inhibitor. Treat it as an MAOI during the session window even though clinical reversibility is not established. Start with a microtest of 0.5-1 mg to gauge sensitivity; community trials report activity at 1-2 mg and full days' worth of effects from 8-12 mg.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 30-90 min 1-2 hrs 4-8 hrs 4-8 hrs 12-48 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 2.5
    Light 2/10

    Mild body load and visuals with low headspace

    Visual Intensity ×3
    4
    color enhancement tracers
    Headspace Depth ×3
    1
    time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    5
    vasoconstriction teeth grinding increased heart rate
    Empathogen 5.0
    Moderate+ 5/10

    Moderate stimulation and sensory enhancement with mild empathy, low euphoria

    Empathy / Social Openness ×3
    5
    entactogenic warmth and sociability increased sociability
    Euphoria / Mood Elevation ×2
    3
    euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Stimulant 4.2
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    3
    thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 5-Cl-AMT
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7โ€“14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Pupil dilation
    • Mild tremor or jaw tension
    • Nystagmus
    • Increased heart rate
    • Teeth grinding
    • Vasoconstriction
    • Insomnia
    • Increased perspiration
    Neutral
    • Increased body temperature
    Positive
    • Entactogenic warmth and sociability
    • Alertness enhancement
    • Euphoria
    • Wakefulness
    • Motivation enhancement
    • Increased sociability
    Negative
    • Anxiety
    Neutral
    • Time distortion
    • Talkativeness
    • Thought acceleration
    Positive
    • Color enhancement
    • Increased music appreciation
    • Tactile enhancement
    • Increased libido
    • Tracers
    Negative
    • Light sensitivity
    • Dehydration
    • Appetite suppression
    • Disinhibition
    Neutral
    • Spontaneous physical sensations

    Combinations TripSit

    5-Cl-AMT's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki