Systematic Exploration of 5-MeO-DPT Since I could not find any general summaries about 5-MeO-DPT (5-Methoxy-N,N-dipropyltrypamine), I wanted to systematically investigate this compound and compare the effects at various doses.
5-MeO-DPT
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- classified Research-chemical
Aliases: O-me-dips, O-methyl-n,n-dipropylserotonin, 5meodpt
Summary
5-MeO-DPT is a Schedule I controlled substance in the United States as a positional isomer of 5-MeO-DiPT, and is also controlled in many other jurisdictions. Its psychedelic effects are described as ambiguous and physically uncomfortable by most users, with minimal visual component and strong auditory distortions. Set and setting are critical; avoid operating vehicles or machinery.
Perspectives
“I typically do not find myself drawn to the 5-MeO tryptamines, though they have plenty of merit. I came into this experience expecting a burdensome trial but was pleasantly surprised by both the gentleness and emotional depth this compound presented.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3mg | 3-5mg | 5-10mg | 10mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-2 hrs | 1-2 hrs | 2-5 hrs |
| Vaporized | - | 1-5 min | 15-45 min | 30-90 min | 2-5 hrs |
Effect Profile
8 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
5.6
Strong
6/10
Moderate visuals with mild headspace and auditory effects, low body load
Visual Intensity
×3
7
color enhancement
drifting
tracers
brightened colour
Headspace Depth
×3
4
emotion enhancement
time distortion
confusion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
2
muscle tension
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Pattern inferred from broader serotonergic psychedelic use: noticeable tolerance if re‑used within 24–72 h; ~1–2 weeks commonly restores much of sensitivity; 2–3 weeks usually returns to baseline. Data quality: anecdotal/community consensus rather than controlled studies.
Cross-Tolerances
Effects
Aggregated from 8 Erowid experience reports
Positive Effects 8
Stimulation
62.5%
70%
Music Enhancement
62.5%
70%
Color Enhancement
50.0%
70%
Euphoria
50.0%
70%
Tactile Enhancement
50.0%
70%
Empathy
37.5%
70%
Focus Enhancement
37.5%
70%
Body High
37.5%
70%
Adverse Effects 3
Nausea
62.5%
70%
Muscle Tension
50.0%
70%
Confusion
37.5%
70%
Combinations
Cross-Check 5-MeO-DPT with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 6 neutral 1 cautionary visit
T0:00- Dose taken. I am in a house surrounded by expansive fields, pine forests, and old ramshackle farm buildings in the Southeastern U.S. It is a hot late summer day, the sun beats down from a blue sky. T0:30- No discernible effects yet. T0:43- A bit of jitteriness and discomfort but this may be placebo.
I took 25mg of 5-MeO-DPT three hours ago today. Before the trip, I had a psychedelic tolerance from a 100ug lysergamide trip 6 days ago. I have extensive experience with substances. I took 5mg of Coreg and 12.5mg of meclizine (a generic motion sickness pill) 2 hours before taking the 5-MeO-DPT.
I've just started my experiments with 5-MeO-DPT and figured I'd submit this considering the lack of reports on this substance. This isn't a very incredible experience, but it's a uncommon compound, so here we go. Background: I took 6mg of this substance yesterday starting at 10:15pm.
I was able to get ahold of some 5-MeO-DPT (note that it NOT DiPT) at a smartshop in Japan, in a 30mg liquid vial. My friend works at the shop so I dosed 10mg and waited for it to kick in. Around 30 minutes later, I noticed it taking effect when it was difficult to concentrate on discussion.
Dosage of 10mg each, following a few hours after coming down from 2C-C trip. Will report as needed. T +0:00 10 mg ingested with coke (the soft drink, if there was doubt). Stronger bitter/chem taste than 60mg's of 2C-C taken earlier. T+0:15 No discernable effects. Considering another 10mgs.
Setting: at home alone on a Friday afternoon. I feel pretty good because of a stressful deadline the previous day, and am looking forward to taking a break from work. I feel a bit tired because of mild caffeine withdrawal.
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