Home
    Disclaimer
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MeO-PYR-T Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 17 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Summary TripSit

    A very odd acting tryptamine, that is very potent. With doses as low as 3mg vapourised causing complete blocks of memory loss.

    Perspectives

    “This stuff is an absolute poison. Within minutes I noticed what can only be called ear-ringing without any ear-ringing. Intense tinnitus with no sound, most uncomfortable. There were two waves of nausea and vomiting of yellow bilious stuff, with thick mucus for saliva. I can’t think straightβ€”muddled. I can’t get answers to questions because I simply cannot form the questions. Eyes closed to music gave no images, but the music sounded OK. Recovery was quite rapid, and I was together again in a few hours. Never again.”

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 0.5-1mg 1-1.5mg 1.5-2mg 2mg+
    Vapourized 0.5-1.5mg 1.5-2mg 2-3mg 3mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects
    Oral 5-20 min 2-6 hrs 1-36 hrs
    Vapourized 1-2 min 1-5 hrs 1-36 hrs

    Effect Profile

    class estimate

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 1 other substance of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.2
    Moderate 4/10

    Moderate visuals and body load with mild headspace

    Visual Intensity ×3
    6
    color enhancement drifting visual distortions brightened colour
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    0
    Body Load / Somatic Effects ×1
    6
    nausea vasoconstriction increased heart rate
    Based on reports from:

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 5-MeO-PYR-T there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "5-MeO-PYR-T (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    5-MeO-PYR-T
    Unit
    mg
    Description
    5-MeO-PYR-T
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): light 0.5-1 Β· common 1-1.5 Β· strong 1.5-2 Β· heavy 2+
    Vapourized dose (mg): light 0.5-1.5 Β· common 1.5-2 Β· strong 2-3 Β· heavy 3+
    
    Oral duration: onset 5-20m Β· peak 2-6h Β· after-effects 1-36h
    Vapourized duration: onset 1-2m Β· peak 1-5h Β· after-effects 1-36h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1.25 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects

    Positive
    • Stimulation
    Negative
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    • Nausea
    • Vasoconstriction
    • Restlessness
    Neutral
    • Dilated pupils
    • Sedation
    • Decreased appetite
    Positive
    • Introspection
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    • Empathy
    Negative
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    • Talkativeness
    Positive
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Light sensitivity
    • Appetite suppression
    • Disinhibition
    • Dehydration
    Neutral
    • Visual distortions
    • Dulled perception
    • Drifting

    Combinations TripSit

    Cross-Check 5-MeO-PYR-T with another substance

    PiHKAL / TiHKAL Shulgin

    TiHKAL #43: 5-MeO-pyr-T

    “This stuff is an absolute poison. Within minutes I noticed what can only be called ear-ringing without any ear-ringing. Intense tinnitus with no sound, most uncomfortable. There were two waves of nausea and vomiting of yellow bilious stuff, with thick mucus for saliva. I can’t think straightβ€”muddled. I can’t get answers to questions because I simply cannot form the questions. Eyes closed to music gave no images, but the music sounded OK. Recovery was quite rapid, and I was together again in a few hours. Never again.”

    β€” Alexander Shulgin, TiHKAL (with 0.5 mg, orally)

    Helpful Links