Home
    Disclaimer

    5,6-MDO-DMT

    Summary PsychonautWiki

    5,6-Methylenedioxy-N,N-dimethyltryptamine (also known as 5,6-MDO-DMT) is a lesser-known psychedelic substance of the tryptamine class. It is the 5,6-methylenedioxy analog of DMT.

    Perspectives

    “Nothing.”

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals with mild headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers pattern recognition enhancement visual distortions brightened colour
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    Body Load / Somatic Effects ×1
    4
    nausea increased heart rate

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Nausea
    • Pupil dilation
    • Increased heart rate
    • Insomnia
    • Restlessness
    • Sweating/chills
    Neutral
    • Dilated pupils
    • Decreased appetite
    Positive
    • Introspection
    • Euphoria
    • Wakefulness
    • Empathy
    • Insight
    • Analysis enhancement
    Negative
    • Anxiety
    • Confusion
    Neutral
    • Time distortion
    • Ego softening
    Positive
    • Color enhancement
    • Tracers
    • Enhanced tactile sensation
    • Tactile enhancement
    • Increased music appreciation
    • Pattern recognition enhancement
    • Brightened colour
    Neutral
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations TripSit

    PiHKAL / TiHKAL Shulgin

    TiHKAL #31: 5,6-MDO-DMT

    “Nothing.”

    — Alexander Shulgin, TiHKAL (with 5 mg, smoked)

    Helpful Links