Summary
5F-PY-PICA is a synthetic cannabinoid. Reported effects include euphoria, visual distortions, color enhancement, and anxiety suppression. Limited data is available on its dosage and safety profile.
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Pain relief
- Anxiolysis
Negative
- Dry mouth
- Nausea
- Tachycardia
- Increased heart rate
- Nausea/vomiting
- Sedation
- Spontaneous bodily sensations
- Vasodilation
Positive
- Euphoria
- Thought connectivity
- Anxiety suppression
- Reduced anxiety
Negative
- Anxiety
- Paranoia
- Motor control loss
- Psychosis
- Short-term memory suppression
- Time distortion
Positive
- Color enhancement
- Appetite enhancement
- Increased music appreciation
- Auditory acuity enhancement
Negative
- Dehydration
- Dulled perception
- Visual distortions
- Appetite intensification
- Changes in felt gravity
- Perception of bodily heaviness