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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    6-MDDM

    Aliases: 6-methylenedihydrodesoxymorphine

    Depressant Opioid

    Summary TripSit

    Semisynthetic opioid that is a derivative of Hydromorphone with little history of human use. Roughly around ~80x the potency of Morphine. Structurally related to Desomorphine.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 125ug 187-250ug 375ug 375ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 1-15 min 4-6 hrs 1-10 hrs 4-6.2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.4
    Moderate+ 5/10

    Moderate euphoria with mild pain relief and itching/nausea, low sedation

    Euphoria / Warmth ×3
    7
    euphoria cognitive euphoria mood lift
    Analgesia ×2
    4
    analgesia
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    4
    constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 6-MDDM
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TripSit

    Positive
    • Analgesia
    • Stimulation
    Negative
    • Dry Mouth
    • Increased heart rate
    • Insomnia
    • Pupil dilation
    Neutral
    • Itchiness
    • Relaxant
    • Pupil constriction
    • Sedation
    Positive
    • Euphoria
    • Mood lift
    • Reduced anxiety
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Constipation
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    6-MDDM's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TripSit 📖 PsychonautWiki