Summary
Rodent and cell data show 9-Me-BC up-regulates tyrosine hydroxylase and BDNF, promotes neurite outgrowth, and reverses rotenone/MPTP dopaminergic injury. IC50 ≈1 µM (MAO-A) and 15 µM (MAO-B) imply mild dietary tyramine sensitivity. Users report subtle but clean motivation, pattern-recognition boost, and mood brightening; bitterness limits sublingual dwell time. Common protocol: 10-20 mg daily for 14 days followed by equal washout; higher chronic doses (>40 mg) correlate with anxiety, insomnia, erectile dysfunction, or 'dirty' overstimulation. Lipophilic tissue binding gives multi-day carry-over despite plasma t½ ~2-4 h in rodents.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 30-90 min | 2-4 hrs | 3-6 hrs | 12-24 hrs |
| Sublingual | 10-30 min | 2-4 hrs | 3-6 hrs | 12-24 hrs |
| Intranasal | 5-15 min | 2-4 hrs | 3-6 hrs | 12-24 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Effects
Positive
- Clean Mental Energy
- Reduced Stimulant Tolerance
- Mental/physical stimulation
Negative
- Nausea
- Physical discomfort
- Pupil dilation
- Restlessness
- Sweating/chills
- Dilated pupils
- Decreased appetite
Positive
- Increased Motivation
- Enhanced Working Memory
- Mild Euphoria
- Introspection
- Spiritual insight and mystical experiences
- Unity and interconnectedness
- Spirituality enhancement
Negative
- Anxiety
- Autonomous entity contact
- Existential self-realization
Positive
- Color enhancement
- Brightened colour
Negative
- Appetite Suppression
- Photophobia
- Sexual Side-effects
- Visual distortions
- Intense visual hallucinations and patterns
- Internal hallucination
- External hallucination
- Spontaneous physical sensations