9-Me-BC
Aliases: 9-methyl-norharman
Summary
Rodent and cell data show 9-Me-BC up-regulates tyrosine hydroxylase and BDNF, promotes neurite outgrowth, and reverses rotenone/MPTP dopaminergic injury. IC50 ≈1 µM (MAO-A) and 15 µM (MAO-B) imply mild dietary tyramine sensitivity. Users report subtle but clean motivation, pattern-recognition boost, and mood brightening; bitterness limits sublingual dwell time.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 30-90 min | 2-4 hrs | 3-6 hrs |
| Sublingual | 10-30 min | 2-4 hrs | 3-6 hrs |
| Intranasal | 5-15 min | 2-4 hrs | 3-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.6
Moderate
4/10
Moderate visuals with mild body load, low headspace
Visual Intensity
×3
6
autonomous entity contact
color enhancement
visual distortions
brightened colour
Headspace Depth
×3
2
introspection
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
5
nausea
physical discomfort
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
10d
Half tolerance
4d
Baseline
~10d
Tolerance pattern is inferred from community cycles and MAOI-class experience; no formal human data. Anecdotally, consecutive heavy dosing for a week can blunt effects; spacing doses and cycling (≤14 days on, ≥14 off) is commonly used to mitigate this.
Cross-Tolerances
Effects
Positive
- Clean Mental Energy
- Reduced Stimulant Tolerance
- Mental/physical stimulation
Negative
- Nausea
- Physical discomfort
- Pupil dilation
- Restlessness
- Sweating/chills
- Dilated pupils
- Decreased appetite
Positive
- Increased Motivation
- Enhanced Working Memory
- Mild Euphoria
- Introspection
- Spiritual insight and mystical experiences
- Unity and interconnectedness
- Spirituality enhancement
Negative
- Anxiety
- Autonomous entity contact
- Existential self-realization
Positive
- Color enhancement
- Brightened colour
Negative
- Appetite Suppression
- Photophobia
- Sexual Side-effects
- Visual distortions
- Intense visual hallucinations and patterns
- Internal hallucination
- External hallucination
- Spontaneous physical sensations
Combinations
9-Me-BC's nerd page
Pharmacology, chemical data, effect profiles, and more
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