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    a-PVP molecular structure

    a-PVP Stats & Data

    Flakka Gravel Flocka O-2387 Alpha-pyrrolidinopentiophenone alpha-pvp apvp α-pvp
    NPS DataHub
    MW267.8
    FormulaC15H22ClNO
    CAS5485-65-4
    IUPAC(RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-pentanone.hydrochloride
    SMILES[Cl-].CCCC(N1CCCC1)C(=O)c1ccccc1.[H+]
    InChIKeyROMXVSMENBAYRM-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Stimulant
    Half-Life Unknown in humans; clinical course suggests multi‑hour activity with prolonged after‑effects; formal PK data are lacking.

    Interaction Warnings

    stimulants

    α-PVP can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.

    mdma

    The neurotoxic effects of MDMA may be increased when combined with other stimulants.

    cocaine

    This combination may increase strain on the heart.

    Effect Profile

    Curated + 11 Reports
    Stimulant 6.4

    Strong anxiety/jitters, euphoria, and focus with mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    9
    Focus / Productivity×2
    9
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; clinical course suggests multi‑hour activity with prolonged after‑effects; formal PK data are lacking.
    Addiction Potential
    High. α‑PVP shows strong abuse liability and binge/redose patterns similar to MDPV and other pyrrolidinophenones; users frequently report compulsive use and difficulty stopping within sessions.

    Tolerance Decay

    Full tolerance 2d Half tolerance 4d Baseline ~14d

    Rapid tolerance buildup within/between sessions is widely reported for pyrrolidinophenones; decay back toward baseline likely occurs over 1–2 weeks of abstinence. Values are heuristic, based on stimulant tolerance patterns and user reports; high uncertainty.

    Cross-Tolerances

    Other cathinones (e.g., MDPV, α‑PHP, NEP)
    60% ●○○
    Common stimulants (amphetamine, cocaine)
    30% ●○○

    Experience Report Analysis

    Erowid
    11 Reports
    2012–2016 Date Range
    11 With Age Data
    10 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 11 experience reports (11 Erowid)

    11 Reports
    10 Effects Detected
    6 Positive
    3 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 6

    Euphoria 81.8% 70%
    Stimulation 54.5% 70%
    Focus Enhancement 45.5% 70%
    Empathy 45.5% 70%
    Pain Relief 27.3% 70%
    Tactile Enhancement 27.3% 70%

    Adverse Effects 3

    Anxiety 72.7% 70%
    Increased Heart Rate 63.6% 70%
    Psychosis 27.3% 70%

    Form / Preparation

    Most common forms and preparations reported

    Redose Patterns

    Redosing behavior across 10 reports

    60.0% Redosed
    1.8 Avg Doses
    65m Median Interval

    Harm Reduction

    drugs.wiki

    α‑PVP is a high‑potency NDRI‑like stimulant closely related to MDPV; clinical presentations consistently match a sympathomimetic toxidrome (tachycardia, hypertension, agitation, hyperthermia), and fatalities and excited delirium have been documented. Smoking/vaporizing and IV routes are associated with very rapid onset, intense reinforcement, and binges; avoid these routes or use extreme caution as compulsive redosing can escalate toxicity quickly. Mis‑sold cathinone products are common: recent Swiss drug checking found alpha‑PVP sold as 3‑MMC; a typical 3‑MMC oral dose (100–200 mg) would be a massive overdose if the material were α‑PVP (active at single‑digit milligrams). Test samples via a trusted drug checking service; note that home reagents often cannot distinguish between specific cathinones. If severe agitation, chest pain, confusion, or overheating occur, seek emergency care; medical management of sympathomimetic toxicity typically prioritizes benzodiazepines for sedation, cooling, IV fluids, and monitoring—do not rely on self‑administered sedatives. Avoid combining with MAOIs or additional stimulants; these combinations substantially increase risks of hypertensive crisis, hyperthermia, seizures, and arrhythmias. Hydrate with electrolytes and take cooling breaks during physical activity, but avoid overconsumption of plain water to reduce hyponatremia risk. Injecting carries high risks (infection, blood‑borne viruses, rapid toxicity); if injecting, always use sterile equipment and never share; safer‑use facilities may offer supervised spaces and supplies in some regions. Do not drive or operate machinery during effects or comedown; stimulants impair judgment during the rise and can leave rebound fatigue and anxiety as they wear off. Dependence risk is significant; plan sessions with hard stopping rules (no access to stash; alarms to stop; prearranged sleep and nutrition) and long breaks between uses.

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